Detailed view for PY04443

Basic information

TDR Targets ID: 538107
Plasmodium yoelii, importin beta-1 subunit
Source Database / ID: 

pI: 4.5627 | Length (AA): 877 | MW (Da): 100501 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03810   Importin-beta N-terminal domain
PF13513   HEAT-like repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0008536   Ran GTPase binding  
GO:0005488   binding  
GO:0006886   intracellular protein transport  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 877 2x19 (B) 25 938 12.00 0 1 0.96536 0.3
5 836 4xri (A) 6 828 30.00 0 1 1.37229 -1.04
6 450 1ibr (B) 3 445 32.00 0 1 0.950912 -1.08
327 469 4uad (A) 254 387 27.00 0.13 0.94 0.448656 -0.72
364 440 1te4 (A) 19 80 34.00 0 0.6 0.182299 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127843)

Species Accession Gene Product
Arabidopsis thaliana AT3G08947   armadillo/beta-catenin-like repeat-containing protein
Arabidopsis thaliana AT3G08943   armadillo/beta-catenin-like repeat-containing protein
Arabidopsis thaliana AT5G53480   armadillo/beta-catenin-like repeat-containing protein
Babesia bovis BBOV_IV000520   importin beta subunit, putative
Brugia malayi Bm1_57540   Importin beta-1 subunit
Candida albicans CaO19.3681   karyopherin-beta
Candida albicans CaO19.11165   karyopherin-beta
Caenorhabditis elegans CELE_F28B3.8   Protein IMB-1
Cryptosporidium hominis Chro.70341   importin-beta2
Cryptosporidium parvum cgd7_3030   importin/karyopherin
Drosophila melanogaster Dmel_CG2637   Female sterile (2) Ketel
Echinococcus granulosus EgrG_000807600   importin subunit beta 1
Entamoeba histolytica EHI_171760   hypothetical protein
Echinococcus multilocularis EmuJ_000807600   importin subunit beta 1
Homo sapiens 3837   karyopherin (importin) beta 1
Leishmania braziliensis LbrM.20.0470   importin beta-1 subunit, putative
Leishmania donovani LdBPK_340510.1   importin beta-1 subunit, putative
Leishmania infantum LinJ.34.0510   importin beta-1 subunit, putative
Leishmania major LmjF.34.0490   importin beta-1 subunit, putative
Leishmania mexicana LmxM.33.0490   importin beta-1 subunit, putative
Loa Loa (eye worm) LOAG_04985   hypothetical protein
Mus musculus ENSMUSG00000001440   karyopherin (importin) beta 1
Neospora caninum NCLIV_001890   hypothetical protein
Oryza sativa 4338508   Os05g0353400
Oryza sativa 4332526   Os03g0294600
Oryza sativa 4352566   Os12g0568800
Plasmodium berghei PBANKA_1422400   importin beta, putative
Plasmodium falciparum PF3D7_0815200   importin beta, putative
Plasmodium knowlesi PKNH_1425100   importin beta, putative
Plasmodium vivax PVX_123010   importin-beta 2, putative
Plasmodium yoelii PY04443   importin beta-1 subunit
Saccharomyces cerevisiae YLR347C   Kap95p
Schistosoma japonicum Sjp_0119190   Importin subunit beta, putative
Schistosoma japonicum Sjp_0004060   Importin subunit beta-1, putative
Schistosoma mansoni Smp_038080.2   importin beta-1
Schmidtea mediterranea mk4.005763.01  
Trypanosoma brucei gambiense Tbg972.10.3620   importin beta-1 subunit, putative
Trypanosoma brucei Tb11.v5.0837   importin beta-1 subunit, putative
Trypanosoma brucei Tb927.10.2900   importin beta-1 subunit, putative
Trypanosoma congolense TcIL3000_10_2510   importin beta-1 subunit, putative
Trypanosoma cruzi TcCLB.504105.150   importin beta-1 subunit, putative
Toxoplasma gondii TGME49_295040   HEAT repeat-containing protein
Theileria parva TP01_0072   importin beta, putative
Trichomonas vaginalis TVAG_188290   importin beta-1, putative
Trichomonas vaginalis TVAG_244490   Importin beta-1 subunit, putative
Trichomonas vaginalis TVAG_364430   Importin beta-1 subunit, putative

Essentiality

PY04443 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2900 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2900 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2900 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2900 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F28B3.8 Caenorhabditis elegans embryonic lethal wormbase
YLR347C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1422400 Plasmodium berghei Essential plasmo
TGME49_295040 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens karyopherin (importin) beta 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PY04443 (Plasmodium yoelii), importin beta-1 subunit
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