Detailed view for PF3D7_1234100

Basic information

TDR Targets ID: 5382
Plasmodium falciparum, bromodomain protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.5449 | Length (AA): 3896 | MW (Da): 466016 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 27 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3654 3811 1eqf (A) 1451 1617 26.00 0.0000000000016 1 0.44 -1
3697 3806 1x0j (A) 74 185 23.00 0 1 0.38 -2.08
3698 3802 2fsa (A) 69 173 27.00 0 1 0.63 -2.52
3705 3807 1e6i (A) 335 437 26.00 0 1 0.61 -2.42
174 1187 3vuo (A) 50 1175 23.00 0.00083 0.89 0.161067 1.66
368 400 2emk (A) 8 41 15.00 0.71 0.01 0.14667 -0.86
769 1176 1z0h (A) 856 1214 28.00 0.45 0.15 -0.0244772 1.82
1379 1698 2fds (A) 18 324 19.00 0.41 0.68 0.189636 0.27
3662 3781 1eqf (A) 1455 1587 35.00 0.0038 1 0.399601 -0.31
3691 3806 2grc (A) 1461 1569 27.00 0.36 1 0.414574 -0.87
3701 3782 4ldf (A) 12 93 27.00 0.27 0.86 0.456847 -0.92
3706 3809 1e6i (A) 336 439 26.00 0.97 1 0.491194 -1.48
3732 3816 3fkm (X) 368 445 42.00 0.02 0.57 0.275617 0.71
168 1185 3vuo (A) 50 1175 23.00 0.00028 0.97 0.173629 1.7
207 288 2wbs (A) 400 482 11.00 0.00068 0.02 0.083797 -0.23
232 268 2en7 (A) 8 44 8.00 0.62 0 0.0523292 -0.05
516 1000 2nyy (A) 724 1265 27.00 0.027 0.88 0.0327984 1.86
641 973 3mpp (G) 894 1209 28.00 0.96 0.4 0.0630624 1.69
907 1178 4u0r (A) 175 495 22.00 0.17 0.05 0.191317 -0.02
1780 2209 4ckb (D) 302 743 25.00 0.97 0.7 -0.00121794 1.98
3692 3810 1eqf (A) 1455 1587 34.00 0.0064 1 0.382526 -0.35
3720 3835 2grc (A) 1461 1569 27.00 0.37 1 0.413762 -0.87
3721 3833 4nxj (A) 2 113 30.00 0.023 1 0.503797 -1.2
3730 3811 4ldf (A) 12 93 27.00 0.28 0.86 0.456097 -0.92
3735 3836 1e6i (A) 336 437 26.00 0.01 1 0.493194 -1.2
3736 3810 5cq8 (A) 1874 1948 35.00 0.92 1 0.500313 -0.44
3751 3831 3qzt (A) 93 170 38.00 0.049 0.79 0.379842 0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, early ring, late ring, late trophozoite, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, gametocyte, merozoite, early schizont, early trophozoite, late schizont, Oocyst, Ring, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_172468)

Species Accession Gene Product
Plasmodium berghei PBANKA_1448700   bromodomain protein, putative
Plasmodium falciparum PF3D7_1234100   bromodomain protein, putative
Plasmodium knowlesi PKNH_1453500   bromodomain protein, putative
Plasmodium vivax PVX_100657   conserved Plasmodium protein, unknown function
Plasmodium yoelii PY03752   Bromodomain, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1234100 (Plasmodium falciparum), bromodomain protein, putative
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