Detailed view for TcCLB.508461.80

Basic information

TDR Targets ID: 54007
Trypanosoma cruzi, prostaglandin F2alpha synthase
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4185 | Length (AA): 379 | MW (Da): 42238 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00724   NADH:flavin oxidoreductase / NADH oxidase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0010181   FMN binding  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 378 1icp (A) 11 373 36.00 0 1 1.42 -1.27
5 377 1vyr (A) 3 364 38.00 0 1 1.43 -1.35
7 378 2gou (A) 5 364 37.00 0 1 1.53 -1.35
1 378 4e2b (A) 1 378 99.00 0 1 2.26306 -1.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3ATY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3ATZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4E2B:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4E2D:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126789)

Species Accession Gene Product
Arabidopsis thaliana AT1G76680   12-oxophytodienoate reductase 1
Arabidopsis thaliana AT1G76690   12-oxophytodienoate reductase 2
Arabidopsis thaliana AT2G06050   12-oxophytodienoate reductase 3
Candida albicans CaO19.3442   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.7772   estrogen-binding protein
Candida albicans CaO19.125   estrogen-binding protein
Candida albicans CaO19.10947   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.10744   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.3443   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.3433   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.5816   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.13238   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.10937   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.10946   potential NADH-dependent flavin oxidoreductase
Candida albicans CaO19.3234   potential NADH-dependent flavin oxidoreductase
Caenorhabditis elegans CELE_F17A9.4   Protein F17A9.4
Caenorhabditis elegans CELE_Y73C8C.10   Protein Y73C8C.10
Caenorhabditis elegans CELE_F17A9.5   Protein F17A9.5
Caenorhabditis elegans CELE_T10B5.8   Protein T10B5.8
Caenorhabditis elegans CELE_F56D5.3   Protein F56D5.3
Escherichia coli b1650   chromate reductase, quinone reductase, FMN-linked
Leishmania braziliensis LbrM.12.0820   n-ethylmaleimide reductase-like protein
Leishmania braziliensis LbrM.12.0810   NADH:flavin oxidoreductase/NADH oxidase, putative
Leishmania donovani LdBPK_120730.1   NADH:flavin oxidoreductase/NADH oxidase, putative
Leishmania donovani LdBPK_120740.1   n-ethylmaleimide reductase-like protein
Leishmania infantum LinJ.12.0730   NADH:flavin oxidoreductase/NADH oxidase, putative
Leishmania infantum LinJ.12.0740   n-ethylmaleimide reductase-like protein
Leishmania major LmjF.12.1140   n-ethylmaleimide reductase-like protein
Leishmania major LmjF.12.1130   NADH:flavin oxidoreductase/NADH oxidase, putative
Leishmania mexicana LmxM.12.1130   NADH:flavin oxidoreductase/NADH oxidase, putative
Leishmania mexicana LmxM.12.1140   n-ethylmaleimide reductase-like protein
Mycobacterium tuberculosis Rv3359   Possible oxidoreductase
Oryza sativa 4340489   Os06g0216200
Oryza sativa 4340484   Os06g0215500
Oryza sativa 4340485   Os06g0215600
Oryza sativa 4340486   Os06g0215900
Oryza sativa 4345762   Os08g0459600
Oryza sativa 4340490   Os06g0216300
Oryza sativa 4329684   Os02g0559400
Saccharomyces cerevisiae YHR179W   Oye2p
Saccharomyces cerevisiae YPL171C   Oye3p
Trypanosoma cruzi TcCLB.506147.9   prostaglandin F2alpha synthase
Trypanosoma cruzi TcCLB.507617.9   prostaglandin F2alpha synthase
Trypanosoma cruzi TcCLB.508461.80   prostaglandin F2alpha synthase
Trichomonas vaginalis TVAG_411930   N-ethylmaleimide reductase, putative
Trichomonas vaginalis TVAG_265760   N-ethylmaleimide reductase, putative

Essentiality

TcCLB.508461.80 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1650 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.508461.80 (Trypanosoma cruzi), prostaglandin F2alpha synthase
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