Detailed view for Tbg972.10.1360

Basic information

TDR Targets ID: 540905
Trypanosoma brucei gambiense, serine carboxypeptidase III precursor, putative,serine peptidase, Clan SC, Family S10
Source Database / ID: 

pI: 4.7598 | Length (AA): 466 | MW (Da): 51846 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00450   Serine carboxypeptidase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004185   serine carboxypeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Lysosome (KEGG)
Renin-angiotensin system (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
30 464 4ci9 (A) 1 451 27.00 0 1 1.27398 -0.56
35 462 1cpy (A) 1 417 35.00 0 1 1.36995 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126663)

Species Accession Gene Product
Arabidopsis thaliana AT3G52000   serine carboxypeptidase-like 36
Arabidopsis thaliana AT3G25420   serine carboxypeptidase-like 21
Arabidopsis thaliana AT3G52020   serine carboxypeptidase-like 39
Arabidopsis thaliana AT2G05850   serine carboxypeptidase-like 38
Arabidopsis thaliana AT3G52010   serine carboxypeptidase-like 37
Arabidopsis thaliana AT5G22980   serine carboxypeptidase-like 47
Arabidopsis thaliana AT3G10410   serine carboxypeptidase-like 49
Arabidopsis thaliana AT4G12910   serine carboxypeptidase-like 20
Arabidopsis thaliana AT3G45010   serine carboxypeptidase-like 48
Brugia malayi Bm1_43130   Serine carboxypeptidase F41C3.5 precursor
Candida albicans CaO19.11612   one of three Carboxypeptidase Y-like genes
Candida albicans CaO19.2474   one of three Carboxypeptidase Y-like genes
Candida albicans CaO19.4135   one of three Carboxypeptidase Y-like genes
Candida albicans CaO19.10011   one of three Carboxypeptidase Y-like genes
Candida albicans CaO19_1339   hypothetical protein
Candida albicans CaO19.1339   one of three Carboxypeptidase Y-like genes
Caenorhabditis elegans CELE_Y16B4A.2   Protein Y16B4A.2
Caenorhabditis elegans CELE_F13D12.6   Protein F13D12.6
Caenorhabditis elegans CELE_Y40D12A.2   Protein Y40D12A.2
Caenorhabditis elegans CELE_F41C3.5   Protein F41C3.5
Caenorhabditis elegans CELE_K10C2.1   Protein K10C2.1
Caenorhabditis elegans CELE_K10C2.12   Protein K10C2.12
Dictyostelium discoideum DDB_G0291912   carboxypeptidase C
Dictyostelium discoideum DDB_G0274511   peptidase S10 family protein
Drosophila melanogaster Dmel_CG31823   CG31823 gene product from transcript CG31823-RA
Drosophila melanogaster Dmel_CG4572   CG4572 gene product from transcript CG4572-RD
Echinococcus granulosus EgrG_000181400   family S10 non peptidase ue S10 family
Echinococcus granulosus EgrG_000170200   lysosomal protective protein
Echinococcus multilocularis EmuJ_000170200   lysosomal protective protein
Echinococcus multilocularis EmuJ_000181400   family S10 non peptidase ue (S10 family)
Homo sapiens ENSG00000064601   cathepsin A
Homo sapiens ENSG00000106066   carboxypeptidase, vitellogenic-like
Leishmania braziliensis LbrM.18.0510   serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10
Leishmania donovani LdBPK_180450.1   serine carboxypeptidase (CBP1), putative
Leishmania infantum LinJ.18.0450   serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10
Leishmania major LmjF.18.0450   serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10
Leishmania mexicana LmxM.18.0450   serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10
Loa Loa (eye worm) LOAG_04094   hypothetical protein
Mus musculus ENSMUSG00000017760   cathepsin A
Mus musculus ENSMUSG00000052955   carboxypeptidase, vitellogenic-like
Oryza sativa 4328060   Os02g0114200
Oryza sativa 4332998   Os03g0386800
Oryza sativa 4335479   Os04g0321700
Oryza sativa 4343226   Os07g0479300
Oryza sativa 4337873   Os05g0158500
Oryza sativa 4351908   Os12g0257000
Onchocerca volvulus OVOC10476   Uncharacterized serine carboxypeptidase homolog
Saccharomyces cerevisiae YMR297W   carboxypeptidase C PRC1
Saccharomyces cerevisiae YBR139W   carboxypeptidase C
Schistosoma japonicum Sjp_0024270   Lysosomal protective protein precursor, putative
Schistosoma japonicum Sjp_0023760   expressed protein
Schistosoma japonicum Sjp_0301570   ko:K01287 carboxypeptidase C [EC3.4.16.5], putative
Schistosoma mansoni Smp_172590   family S10 unassigned peptidase (S10 family)
Schistosoma mansoni Smp_163970   family S10 non-peptidase homologue (S10 family)
Schmidtea mediterranea mk4.025484.00  
Schmidtea mediterranea mk4.033461.00   Lysosomal protective protein
Schmidtea mediterranea mk4.010790.00   Lysosomal protective protein
Schmidtea mediterranea mk4.024605.00  
Schmidtea mediterranea mk4.019153.02   Lysosomal protective protein
Schmidtea mediterranea mk4.019153.01  
Schmidtea mediterranea mk4.026704.00  
Trypanosoma brucei gambiense Tbg972.10.1410   serine carboxypeptidase III precursor, putative
Trypanosoma brucei gambiense Tbg972.10.1380   serine carboxypeptidase III precursor, putative
Trypanosoma brucei gambiense Tbg972.10.1360   serine carboxypeptidase III precursor, putative,serine peptidase, Clan SC, Family S10
Trypanosoma brucei gambiense Tbg972.10.1400   serine carboxypeptidase III precursor, putative
Trypanosoma brucei Tb927.10.1030   serine peptidase, Clan SC, Family S10
Trypanosoma brucei Tb927.10.1050   serine peptidase, Clan SC, Family S10
Trypanosoma brucei Tb927.10.1040   serine peptidase, Clan SC, Family S10
Trypanosoma congolense TcIL3000_10_860   serine peptidase, Clan SC, Family S10
Trypanosoma cruzi TcCLB.508671.20   serine carboxypeptidase (CBP1), putative
Trypanosoma cruzi TcCLB.508671.10   serine carboxypeptidase (CBP1), putative
Trypanosoma cruzi TcCLB.509695.210   serine peptidase, Clan SC, Family S10, putative
Trypanosoma cruzi TcCLB.509695.220   serine peptidase, Clan SC, Family S10, putative

Essentiality

Tbg972.10.1360 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1030 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1030 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.1030 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F13D12.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y40D12A.2 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cathepsin A Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tbg972.10.1360 (Trypanosoma brucei gambiense), serine carboxypeptidase III precursor, putative,serine peptidase, Clan SC, Family S10
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