pI: 4.2859 |
Length (AA): 361 |
MW (Da): 38893 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 361 | 1oqy (A) | 3 | 361 | 25.00 | 0 | 1 | 1 | 1.19 |
1 | 69 | 1yj1 (A) | 1 | 71 | 25.00 | 0 | 1 | 0.68 | -2.45 |
3 | 361 | 1oqy (A) | 5 | 361 | 25.00 | 0 | 1 | 1.11 | 1.35 |
1 | 69 | 5hpk (B) | 1 | 71 | 23.00 | 0.22 | 1 | 0.690336 | -2.15 |
1 | 361 | 1oqy (A) | 3 | 361 | 27.00 | 0 | 1 | 1.1232 | 1.27 |
1 | 64 | 1wy8 (A) | 8 | 75 | 28.00 | 0 | 1 | 0.575485 | -1.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127320)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G16190 | DNA repair protein RAD23A |
Arabidopsis thaliana | AT5G38470 | ubiquitin receptor RAD23d |
Arabidopsis thaliana | AT3G02540 | UV excision repair protein RAD23C |
Arabidopsis thaliana | AT1G79650 | ubiquitin receptor RAD23b |
Babesia bovis | BBOV_IV009040 | DNA repair protein Rad23, putatitve |
Brugia malayi | Bm1_43250 | UV excision repair protein Rad23 containing protein |
Candida albicans | CaO19.1494 | similar to S. cerevisiae repairosome nucleotide excision repair protein (Ubiquitin-like protein) |
Candida albicans | CaO19.9071 | similar to S. cerevisiae repairosome nucleotide excision repair protein (Ubiquitin-like protein) |
Caenorhabditis elegans | CELE_ZK20.3 | Protein RAD-23 |
Cryptosporidium hominis | Chro.70524 | RAD 23B protein - channel catfish |
Cryptosporidium parvum | cgd7_4730 | RAD23p, UB+UBA domains protein |
Dictyostelium discoideum | DDB_G0286357 | repC-binding protein A |
Drosophila melanogaster | Dmel_CG10694 | CG10694 gene product from transcript CG10694-RA |
Drosophila melanogaster | Dmel_CG1836 | CG1836 gene product from transcript CG1836-RC |
Echinococcus granulosus | EgrG_000444000 | uv excision repair protein rad23 b |
Entamoeba histolytica | EHI_001400 | RAD23 protein, putative |
Echinococcus multilocularis | EmuJ_000444000 | uv excision repair protein rad23 b |
Homo sapiens | ENSG00000179262 | RAD23 homolog A (S. cerevisiae) |
Homo sapiens | ENSG00000119318 | RAD23 homolog B (S. cerevisiae) |
Leishmania braziliensis | LbrM.30.3340 | UV excision repair RAD23-like protein |
Leishmania donovani | LdBPK_303350.1 | UV excision repair RAD23-like protein |
Leishmania infantum | LinJ.30.3350 | UV excision repair RAD23-like protein |
Leishmania major | LmjF.30.3300 | UV excision repair RAD23-like protein |
Leishmania mexicana | LmxM.29.3300 | UV excision repair RAD23-like protein |
Loa Loa (eye worm) | LOAG_12911 | UV excision repair protein Rad23 containing protein |
Mus musculus | ENSMUSG00000003813 | RAD23a homolog (S. cerevisiae) |
Mus musculus | ENSMUSG00000028426 | RAD23b homolog (S. cerevisiae) |
Neospora caninum | NCLIV_002400 | hypothetical protein |
Oryza sativa | 4340699 | Os06g0264300 |
Oryza sativa | 4347014 | Os09g0407200 |
Oryza sativa | 9267284 | Os02g0465112 |
Oryza sativa | 4328500 | Os02g0179300 |
Oryza sativa | 4345632 | Os08g0430200 |
Plasmodium berghei | PBANKA_1210100 | DNA repair protein RAD23, putative |
Plasmodium falciparum | PF3D7_1011700 | DNA repair protein RAD23, putative |
Plasmodium knowlesi | PKNH_0811500 | DNA repair protein RAD23, putative |
Plasmodium vivax | PVX_094805 | DNA repair protein RAD23, putative |
Plasmodium yoelii | PY01513 | putative DNA repair protein RAD23 |
Saccharomyces cerevisiae | YEL037C | Rad23p |
Schistosoma japonicum | Sjp_0052700 | UV excision repair protein RAD23 homolog B, putative |
Schistosoma japonicum | Sjp_0118730 | UV excision repair protein RAD23 homolog B, putative |
Schistosoma mansoni | Smp_061920.2 | uv excision repair protein rad23 |
Schistosoma mansoni | Smp_061920.1 | uv excision repair protein rad23 |
Schmidtea mediterranea | mk4.001677.02 | |
Trypanosoma brucei gambiense | Tbg972.6.4470 | UV excision repair RAD23 protein, putative |
Trypanosoma brucei | Tb927.6.4650 | UV excision repair RAD23 protein, putative |
Trypanosoma cruzi | TcCLB.506833.60 | UV excision repair RAD23-like protein, putative |
Trypanosoma cruzi | TcCLB.511731.10 | UV excision repair RAD23-like protein, putative |
Toxoplasma gondii | TGME49_295340 | UV excision repair protein Rad23 protein |
Theileria parva | TP01_0871 | DNA repair protein rad23, putative |
Trichomonas vaginalis | TVAG_348290 | UV excision repair protein rad23, putative |
Trichomonas vaginalis | TVAG_392980 | UV excision repair protein rad23, putative |
Trichomonas vaginalis | TVAG_151070 | UV excision repair protein rad23, putative |
Trichomonas vaginalis | TVAG_270770 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_314950 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4650 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4650 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4650 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4650 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1210100 | Plasmodium berghei | Slow | plasmo |
TGME49_295340 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.