Detailed view for TcCLB.474341.9

Basic information

TDR Targets ID: 54162
Trypanosoma cruzi, dynein heavy chain, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.7413 | Length (AA): 509 | MW (Da): 57077 | Paralog Number: 19

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12775   P-loop containing dynein motor region D3

Gene Ontology

Mouse over links to read term descriptions.
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
273 508 2chg (A) 5 207 13.00 0.000000001 0.6 0.51 -0.58
275 507 1sxj (C) 15 214 15.00 0.000000013 0.7 0.49 -0.09
1 474 3vkh (A) 2306 2829 31.00 0 1 1.04944 0.75
1 508 3vkg (A) 2306 2860 27.00 0 1 1.22244 0.31
1 506 3vkg (A) 2306 2858 24.00 0 1 1.23761 0.41
303 464 2p65 (A) 33 186 18.00 0 0.1 0.431671 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126558)

Species Accession Gene Product
Babesia bovis BBOV_IV009380   cytoplasmic dynein heavy chain, putative
Brugia malayi Bm1_41435   CG7507-PA
Candida albicans CaO19.5999   cytoplasmic dynein heavy chain similar to E.gossypii AgDHC1 and S. cerevisiae DYN1 (YKR054C)
Candida albicans CaO19.13420   cytoplasmic dynein heavy chain similar to E.gossypii AgDHC1 and S. cerevisiae DYN1 (YKR054C)
Caenorhabditis elegans CELE_T21E12.4   Protein DHC-1
Caenorhabditis elegans CELE_F18C12.1   Protein CHE-3
Cryptosporidium hominis Chro.10093   cytoplasmic dynein 1-related
Cryptosporidium hominis Chro.10094   dynein heavy chain
Cryptosporidium parvum cgd1_750   dynein heavy chain
Dictyostelium discoideum DDB_G0276355   cytoplasmic dynein heavy chain
Drosophila melanogaster Dmel_CG7507   Dynein heavy chain 64C
Drosophila melanogaster Dmel_CG5526   Dynein heavy chain at 36C
Drosophila melanogaster Dmel_CG15148   beethoven
Drosophila melanogaster Dmel_CG3339   CG3339 gene product from transcript CG3339-RC
Drosophila melanogaster Dmel_CG9492   CG9492 gene product from transcript CG9492-RF
Drosophila melanogaster Dmel_CG15804   Dynein heavy chain at 62B
Drosophila melanogaster Dmel_CG17150   CG17150 gene product from transcript CG17150-RD
Drosophila melanogaster Dmel_CG1842   Dynein heavy chain at 89D
Drosophila melanogaster Dmel_CG3723   Dynein heavy chain at 93AB
Drosophila melanogaster Dmel_CG40444   male fertility factor kl5
Drosophila melanogaster Dmel_CG7092   Dynein heavy chain at 16F
Drosophila melanogaster Dmel_CG17866   male fertility factor kl2
Drosophila melanogaster Dmel_CG17629   male fertility factor kl3
Echinococcus granulosus EgrG_000536600   dynein heavy chain
Echinococcus granulosus EgrG_000953100   dynein beta chain ciliary
Echinococcus granulosus EgrG_000621000   dynein heavy chain
Echinococcus granulosus EgrG_000832000   dynein heavy chain
Echinococcus granulosus EgrG_000629000   dynein beta chain ciliary
Echinococcus granulosus EgrG_000893200   dynein heavy chain
Echinococcus granulosus EgrG_000596700   dynein heavy chain
Echinococcus granulosus EgrG_000628900   dynein heavy chain
Echinococcus granulosus EgrG_000868400   dynein heavy chain
Echinococcus granulosus EgrG_000536500   dynein heavy chain
Echinococcus granulosus EgrG_000475900   dynein heavy chain
Echinococcus granulosus EgrG_001028600   dynein heavy chain
Echinococcus granulosus EgrG_000725200   dynein heavy chain
Echinococcus granulosus EgrG_000255900   dynein heavy chain
Echinococcus granulosus EgrG_000592300   dynein heavy chain
Echinococcus granulosus EgrG_000868300   dynein heavy chain
Echinococcus granulosus EgrG_000618250   dynein heavy chain
Echinococcus granulosus EgrG_000596000   dynein heavy chain
Echinococcus granulosus EgrG_000629100   dynein beta chain ciliary
Echinococcus multilocularis EmuJ_000832000   dynein heavy chain
Echinococcus multilocularis EmuJ_000868400   dynein heavy chain
Echinococcus multilocularis EmuJ_000536600   dynein heavy chain
Echinococcus multilocularis EmuJ_000725200   dynein heavy chain
Echinococcus multilocularis EmuJ_000596000   dynein heavy chain
Echinococcus multilocularis EmuJ_000536500   dynein heavy chain
Echinococcus multilocularis EmuJ_000621000   dynein heavy chain
Echinococcus multilocularis EmuJ_000628900   dynein heavy chain
Echinococcus multilocularis EmuJ_000893200   dynein heavy chain
Echinococcus multilocularis EmuJ_000475900   dynein heavy chain
Echinococcus multilocularis EmuJ_000953100   dynein beta chain ciliary
Echinococcus multilocularis EmuJ_000629100   dynein beta chain, ciliary
Echinococcus multilocularis EmuJ_000596700   dynein heavy chain
Echinococcus multilocularis EmuJ_000255900   dynein heavy chain
Echinococcus multilocularis EmuJ_000592300   dynein heavy chain
Echinococcus multilocularis EmuJ_000618250   dynein heavy chain
Echinococcus multilocularis EmuJ_000629000   dynein beta chain, ciliary
Echinococcus multilocularis EmuJ_000868300   dynein heavy chain
Echinococcus multilocularis EmuJ_001028600   dynein heavy chain
Giardia lamblia GL50803_10538   Dynein heavy chain
Giardia lamblia GL50803_17265   Dynein heavy chain
Giardia lamblia GL50803_111950   Dynein heavy chain
Giardia lamblia GL50803_40496   Dynein heavy chain
Giardia lamblia GL50803_17243   Dynein heavy chain
Giardia lamblia GL50803_16804   Dynein heavy chain
Giardia lamblia GL50803_94440   Dynein heavy chain
Giardia lamblia GL50803_100906   Dynein heavy chain, putative
Giardia lamblia GL50803_37985   Dynein heavy chain
Giardia lamblia GL50803_8172   Dynein heavy chain
Giardia lamblia GL50803_103059   Dynein heavy chain
Giardia lamblia GL50803_101138   Dynein heavy chain
Homo sapiens ENSG00000114841   dynein, axonemal, heavy chain 1
Homo sapiens ENSG00000183914   dynein, axonemal, heavy chain 2
Homo sapiens ENSG00000039139   dynein, axonemal, heavy chain 5
Homo sapiens ENSG00000007174   dynein, axonemal, heavy chain 9
Homo sapiens ENSG00000118997   dynein, axonemal, heavy chain 7
Homo sapiens ENSG00000158486   dynein, axonemal, heavy chain 3
Homo sapiens ENSG00000187240   dynein, cytoplasmic 2, heavy chain 1
Homo sapiens ENSG00000187775   dynein, axonemal, heavy chain 17
Homo sapiens ENSG00000105877   dynein, axonemal, heavy chain 11
Homo sapiens ENSG00000174844   dynein, axonemal, heavy chain 12
Homo sapiens ENSG00000197653   dynein, axonemal, heavy chain 10
Homo sapiens ENSG00000197102   dynein, cytoplasmic 1, heavy chain 1
Homo sapiens ENSG00000185842   dynein, axonemal, heavy chain 14
Homo sapiens ENSG00000115423   dynein, axonemal, heavy chain 6
Homo sapiens ENSG00000124721   dynein, axonemal, heavy chain 8
Leishmania braziliensis LbrM.14.1050   dynein heavy chain, putative
Leishmania braziliensis LbrM.27.1870   dynein heavy chain, putative
Leishmania braziliensis LbrM.25.0860   dynein heavy chain, putative
Leishmania braziliensis LbrM.22.1010   dynein heavy chain, cytosolic, putative
Leishmania braziliensis LbrM.13.1510   dynein heavy chain, putative
Leishmania braziliensis LbrM.26.1040   dynein heavy chain, putative
Leishmania braziliensis LbrM.28.0630   dynein heavy chain, putative
Leishmania braziliensis LbrM.27.2710   dynein heavy chain, putative
Leishmania braziliensis LbrM.28.3090   dynein heavy chain, putative
Leishmania braziliensis LbrM.35.1070   dynein heavy chain, putative
Leishmania braziliensis LbrM.20.3490   dynein heavy chain, putative
Leishmania braziliensis LbrM.23.1430   dynein heavy chain, putative
Leishmania braziliensis LbrM.20.3790   dynein heavy chain, putative
Leishmania donovani LdBPK_251010.1   dynein heavy chain, putative
Leishmania donovani LdBPK_231570.1   dynein heavy chain, putative
Leishmania donovani LdBPK_261000.1   Inner arm dynein 5-1
Leishmania donovani LdBPK_361010.1   dynein heavy chain, putative
Leishmania donovani LdBPK_131390.1   dynein heavy chain, putative
Leishmania donovani LdBPK_271650.1   dynein heavy chain, putative
Leishmania donovani LdBPK_141130.1   dynein heavy chain, putative
Leishmania donovani LdBPK_343990.1   dynein heavy chain, putative
Leishmania donovani LdBPK_280650.1   dynein heavy chain, putative
Leishmania donovani LdBPK_283110.1   dynein heavy chain, putative
Leishmania donovani LdBPK_220930.1   dynein heavy chain, cytosolic, putative
Leishmania donovani LdBPK_343690.1   dynein heavy chain, putative
Leishmania infantum LinJ.28.0650   dynein heavy chain, putative
Leishmania infantum LinJ.26.1000   dynein heavy chain, putative
Leishmania infantum LinJ.27.1650   dynein heavy chain, putative
Leishmania infantum LinJ.28.3110   dynein heavy chain, putative
Leishmania infantum LinJ.23.1570   dynein heavy chain, putative
Leishmania infantum LinJ.34.3690   dynein heavy chain, putative
Leishmania infantum LinJ.25.1010   dynein heavy chain, putative
Leishmania infantum LinJ.34.3990   dynein heavy chain, putative
Leishmania infantum LinJ.36.1010   dynein heavy chain, putative
Leishmania infantum LinJ.22.0930   dynein heavy chain, cytosolic, putative
Leishmania infantum LinJ.14.1130   dynein heavy chain, putative
Leishmania infantum LinJ.13.1390   dynein heavy chain, putative
Leishmania major LmjF.36.0950   dynein heavy chain, putative
Leishmania major LmjF.22.1110   dynein heavy chain, cytosolic, putative
Leishmania major LmjF.34.4160   dynein heavy chain, putative
Leishmania major LmjF.23.1310   dynein heavy chain, putative
Leishmania major LmjF.26.1020   dynein heavy chain, putative
Leishmania major LmjF.27.1750   dynein heavy chain, putative
Leishmania major LmjF.14.1060   dynein heavy chain, putative
Leishmania major LmjF.28.2880   dynein heavy chain, putative
Leishmania major LmjF.28.0610   dynein heavy chain, putative
Leishmania major LmjF.13.1650   dynein heavy chain, putative
Leishmania major LmjF.25.0980   dynein heavy chain, putative
Leishmania major LmjF.34.3880   dynein heavy chain, putative
Leishmania mexicana LmxM.23.1310   dynein heavy chain, putative
Leishmania mexicana LmxM.33.4160   dynein heavy chain, putative
Leishmania mexicana LmxM.33.3880   dynein heavy chain, putative
Leishmania mexicana LmxM.26.1020   dynein heavy chain, putative
Leishmania mexicana LmxM.14.1060   dynein heavy chain, putative
Leishmania mexicana LmxM.36.0950   dynein heavy chain, putative
Leishmania mexicana LmxM.22.1110   dynein heavy chain, cytosolic, putative
Leishmania mexicana LmxM.28.0610   dynein heavy chain, putative
Leishmania mexicana LmxM.13.1650   dynein heavy chain, putative
Leishmania mexicana LmxM.25.0980   dynein heavy chain, putative
Leishmania mexicana LmxM.28.2880   dynein heavy chain, putative
Leishmania mexicana LmxM.27.1750   dynein heavy chain, putative
Loa Loa (eye worm) LOAG_01146   dynein heavy chain protein 1
Loa Loa (eye worm) LOAG_08827   dynein heavy chain isotype 1B
Loa Loa (eye worm) LOAG_13476   hypothetical protein
Loa Loa (eye worm) LOAG_06125   dynein heavy chain
Mus musculus ENSMUSG00000052861   dynein, axonemal, heavy chain 6
Mus musculus ENSMUSG00000033826   dynein, axonemal, heavy chain 8
Mus musculus ENSMUSG00000022262   dynein, axonemal, heavy chain 5
Mus musculus ENSMUSG00000047193   dynein cytoplasmic 2 heavy chain 1
Mus musculus ENSMUSG00000005237   dynein, axonemal, heavy chain 2
Mus musculus ENSMUSG00000033987   dynein, axonemal, heavy chain 17
Mus musculus ENSMUSG00000018581   dynein, axonemal, heavy chain 11
Mus musculus ENSMUSG00000041144   dynein, axonemal, heavy chain 7B
Mus musculus ENSMUSG00000018707   dynein cytoplasmic 1 heavy chain 1
Mus musculus ENSMUSG00000052273   dynein, axonemal, heavy chain 3
Mus musculus ENSMUSG00000019027   dynein, axonemal, heavy chain 1
Mus musculus ENSMUSG00000101337   dynein, axonemal, heavy chain 7C
Mus musculus 110083   dynein, axonemal, heavy chain 12
Mus musculus ENSMUSG00000056752   dynein, axonemal, heavy chain 9
Mus musculus 240960   dynein, axonemal, heavy chain 14
Mus musculus ENSMUSG00000038011   dynein, axonemal, heavy chain 10
Mus musculus ENSMUSG00000096141   dynein, axonemal, heavy chain 7A
Neospora caninum NCLIV_013820   hypothetical protein
Neospora caninum NCLIV_021800   hypothetical protein
Neospora caninum NCLIV_034170   hypothetical protein
Neospora caninum NCLIV_001450   hypothetical protein
Neospora caninum NCLIV_065960   Dynein heavy chain 1, axonemal, related
Neospora caninum NCLIV_031230   GI17927, related
Neospora caninum NCLIV_044570   hypothetical protein
Neospora caninum NCLIV_013830   Dynein heavy chain family protein, related
Neospora caninum NCLIV_054090   hypothetical protein
Neospora caninum NCLIV_026260   GA26239, related
Neospora caninum NCLIV_050200   GF18580, related
Plasmodium berghei PBANKA_0507300   dynein heavy chain, putative
Plasmodium berghei PBANKA_0214000   dynein heavy chain, putative
Plasmodium berghei PBANKA_0416100   dynein heavy chain, putative
Plasmodium berghei PBANKA_0925400   dynein heavy chain, putative
Plasmodium falciparum PF3D7_1023100   dynein heavy chain, putative
Plasmodium falciparum PF3D7_0905300   dynein heavy chain, putative
Plasmodium falciparum PF3D7_1122900   dynein heavy chain, putative
Plasmodium falciparum PF3D7_0729900   dynein heavy chain, putative
Plasmodium knowlesi PKNH_0214800   dynein heavy chain, putative
Plasmodium knowlesi PKNH_0607600   dynein heavy chain, putative
Plasmodium knowlesi PKNH_0703000   dynein heavy chain, putative
Plasmodium knowlesi PKNH_0920700   dynein heavy chain, putative
Plasmodium vivax PVX_098710   dynein heavy chain, putative
Plasmodium vivax PVX_111560   dynein heavy chain, putative
Plasmodium vivax PVX_091760   dynein heavy chain, putative
Plasmodium vivax PVX_081792   hypothetical protein
Plasmodium yoelii PY00078   dynein beta chain, ciliary
Plasmodium yoelii PY01514   outer arm dynein beta heavy chain
Plasmodium yoelii PY03002   hypothetical protein
Plasmodium yoelii PY04544   axonemal dynein heavy chain 8-related
Plasmodium yoelii PY03506   ciliary outer arm dynein beta heavy chain-related
Plasmodium yoelii PY01799   hypothetical protein
Plasmodium yoelii PY01468   cytoplasmic dynein 1-related
Saccharomyces cerevisiae YKR054C   dynein heavy chain
Schistosoma japonicum Sjp_0023110   Cytoplasmic dynein 2 heavy chain 1, putative
Schistosoma japonicum Sjp_0130030   Dynein heavy chain 6, axonemal, putative
Schistosoma japonicum Sjp_0072850   Dynein heavy chain 2, axonemal, putative
Schistosoma japonicum Sjp_0104080   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0093370   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0070730   Dynein heavy chain 3, axonemal, putative
Schistosoma japonicum Sjp_0124110   Dynein heavy chain 6, axonemal, putative
Schistosoma japonicum Sjp_0086410   ko:K01376 Dynein heavy chain at 93AB [EC:3.6.1.3 3.4.22.-], putative
Schistosoma japonicum Sjp_0119380   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0034420   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0133760   Dynein heavy chain 12, axonemal, putative
Schistosoma japonicum Sjp_0316860   Dynein beta chain, ciliary, putative
Schistosoma japonicum Sjp_0014790   ko:K10408 dynein heavy chain, axonemal, putative
Schistosoma japonicum Sjp_0121420   Dynein heavy chain, cytoplasmic, putative
Schistosoma japonicum Sjp_0084540   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0038060   ko:K01376 DNAH5; dynein, axonemal, heavy chain 5, putative
Schistosoma japonicum Sjp_0046120   ko:K10413 dynein heavy chain 1, cytosolic, putative
Schistosoma japonicum Sjp_0130840   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0079980   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0013600   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0079970   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0073410   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0111420   Dynein heavy chain 3, axonemal, putative
Schistosoma japonicum Sjp_0132920   Dynein heavy chain 6, axonemal, putative
Schistosoma japonicum Sjp_0120060   Dynein heavy chain 6, axonemal, putative
Schistosoma japonicum Sjp_0111170   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0129730   Dynein heavy chain 2, axonemal, putative
Schistosoma japonicum Sjp_0007420   Dynein heavy chain 8, axonemal, putative
Schistosoma japonicum Sjp_0130040   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0123390   IPR013594,Dynein heavy chain, N-terminal region 1,domain-containing
Schistosoma japonicum Sjp_0108580   Dynein heavy chain 3, axonemal, putative
Schistosoma japonicum Sjp_0124230   hypothetical protein
Schistosoma japonicum Sjp_0018060   ko:K10414 dynein heavy chain 2, cytosolic, putative
Schistosoma japonicum Sjp_0116150   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0110560   Dynein heavy chain 12, axonemal, putative
Schistosoma japonicum Sjp_0009170   ko:K10408 dynein heavy chain, axonemal, putative
Schistosoma japonicum Sjp_0014780   Dynein heavy chain 3, axonemal, putative
Schistosoma japonicum Sjp_0034410   Dynein heavy chain 6, axonemal, putative
Schistosoma japonicum Sjp_0079990   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0117720   Dynein-1-alpha heavy chain, flagellar inner arm I1 complex, putative
Schistosoma japonicum Sjp_0066850   Dynein beta chain, ciliary, putative
Schistosoma japonicum Sjp_0062850   expressed protein
Schistosoma japonicum Sjp_0131050   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0067450   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0077950   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0014800   Dynein heavy chain 3, axonemal, putative
Schistosoma japonicum Sjp_0082430   Dynein-1-beta heavy chain, flagellar inner arm I1 complex, putative
Schistosoma japonicum Sjp_0121510   Dynein heavy chain 2, axonemal, putative
Schistosoma japonicum Sjp_0091110   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0091680   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0087250   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0024720   Dynein heavy chain 5, axonemal, putative
Schistosoma japonicum Sjp_0122550   Dynein heavy chain 12, axonemal, putative
Schistosoma japonicum Sjp_0013590   Dynein heavy chain 7, axonemal, putative
Schistosoma japonicum Sjp_0026070   ko:K10408 dynein heavy chain, axonemal, putative
Schistosoma japonicum Sjp_0128550   Dynein heavy chain 2, axonemal, putative
Schistosoma mansoni Smp_156080   dynein heavy chain
Schistosoma mansoni Smp_157410   hypothetical protein
Schistosoma mansoni Smp_160640   dynein heavy chain
Schistosoma mansoni Smp_176300   dynein heavy chain
Schistosoma mansoni Smp_159840   dynein heavy chain
Schistosoma mansoni Smp_153140   ciliary outer arm dynein beta heavy chain-related
Schistosoma mansoni Smp_165620   hypothetical protein
Schistosoma mansoni Smp_158760   dynein heavy chain
Schistosoma mansoni Smp_067620   hypothetical protein
Schistosoma mansoni Smp_165820   dynein heavy chain
Schistosoma mansoni Smp_034920   dynein heavy chain
Schistosoma mansoni Smp_130810   hypothetical protein
Schmidtea mediterranea mk4.004435.03  
Schmidtea mediterranea mk4.007246.01  
Schmidtea mediterranea mk4.020236.00  
Schmidtea mediterranea mk4.026898.00  
Schmidtea mediterranea mk4.000546.16  
Schmidtea mediterranea mk4.000546.19  
Schmidtea mediterranea mk4.001137.10  
Schmidtea mediterranea mk4.030316.00  
Schmidtea mediterranea mk4.022034.01  
Schmidtea mediterranea mk4.002247.03  
Schmidtea mediterranea mk4.004410.06  
Schmidtea mediterranea mk4.004410.00  
Schmidtea mediterranea mk4.007344.01  
Schmidtea mediterranea mk4.004458.00  
Schmidtea mediterranea mk4.015920.00  
Schmidtea mediterranea mk4.034358.00  
Schmidtea mediterranea mk4.023648.01  
Schmidtea mediterranea mk4.011395.03  
Schmidtea mediterranea mk4.001126.01  
Schmidtea mediterranea mk4.000754.03  
Schmidtea mediterranea mk4.001498.08   Dynein heavy chain, putative
Schmidtea mediterranea mk4.047018.00   Cytoplasmic dynein 2 heavy chain 1
Schmidtea mediterranea mk4.014368.00  
Schmidtea mediterranea mk4.001498.10  
Schmidtea mediterranea mk4.013576.01  
Schmidtea mediterranea mk4.010033.02  
Schmidtea mediterranea mk4.022223.01  
Schmidtea mediterranea mk4.007344.02  
Schmidtea mediterranea mk4.001137.04   Dynein heavy chain, putative
Schmidtea mediterranea mk4.014108.00  
Schmidtea mediterranea mk4.001459.03  
Schmidtea mediterranea mk4.000300.08   Dynein heavy chain, putative
Schmidtea mediterranea mk4.001137.05  
Schmidtea mediterranea mk4.000546.03   Dynein heavy chain, putative
Schmidtea mediterranea mk4.000546.04  
Schmidtea mediterranea mk4.000546.01  
Schmidtea mediterranea mk4.002247.04  
Schmidtea mediterranea mk4.004075.02   Dynein heavy chain 11, axonemal
Schmidtea mediterranea mk4.000300.09  
Schmidtea mediterranea mk4.000546.14  
Schmidtea mediterranea mk4.020911.00  
Schmidtea mediterranea mk4.001126.02  
Schmidtea mediterranea mk4.007317.00  
Schmidtea mediterranea mk4.001241.11  
Schmidtea mediterranea mk4.013719.03   Cytoplasmic dynein 2 heavy chain 1
Schmidtea mediterranea mk4.000990.02  
Schmidtea mediterranea mk4.001241.05  
Schmidtea mediterranea mk4.010033.01  
Schmidtea mediterranea mk4.002247.11   Dynein heavy chain 2, axonemal
Schmidtea mediterranea mk4.002143.03  
Schmidtea mediterranea mk4.020145.02  
Schmidtea mediterranea mk4.013576.03  
Schmidtea mediterranea mk4.006874.02  
Schmidtea mediterranea mk4.014279.01  
Schmidtea mediterranea mk4.000990.04  
Schmidtea mediterranea mk4.040090.02  
Schmidtea mediterranea mk4.018634.00  
Schmidtea mediterranea mk4.002247.08  
Schmidtea mediterranea mk4.013719.02   Cytoplasmic dynein 2 heavy chain 1
Schmidtea mediterranea mk4.004905.02  
Schmidtea mediterranea mk4.018634.01  
Schmidtea mediterranea mk4.011395.05  
Schmidtea mediterranea mk4.014279.00  
Schmidtea mediterranea mk4.000546.20  
Schmidtea mediterranea mk4.000990.03   Dynein heavy chain 11, axonemal
Schmidtea mediterranea mk4.030484.00   Dynein heavy chain 11, axonemal
Schmidtea mediterranea mk4.000546.00  
Schmidtea mediterranea mk4.025818.02  
Schmidtea mediterranea mk4.010033.03  
Schmidtea mediterranea mk4.050209.00  
Schmidtea mediterranea mk4.022970.00  
Schmidtea mediterranea mk4.034590.01  
Schmidtea mediterranea mk4.001241.08  
Schmidtea mediterranea mk4.000546.02  
Schmidtea mediterranea mk4.000155.09   Dynein heavy chain 11, axonemal
Schmidtea mediterranea mk4.004410.02  
Schmidtea mediterranea mk4.013576.04  
Schmidtea mediterranea mk4.001241.04  
Schmidtea mediterranea mk4.004458.01  
Schmidtea mediterranea mk4.000624.05   Putative dynein heavy chain
Schmidtea mediterranea mk4.001241.10  
Schmidtea mediterranea mk4.007246.02  
Schmidtea mediterranea mk4.030316.02  
Schmidtea mediterranea mk4.001498.07   Dynein heavy chain, putative
Schmidtea mediterranea mk4.030316.01  
Schmidtea mediterranea mk4.002247.07  
Schmidtea mediterranea mk4.026708.01  
Schmidtea mediterranea mk4.000546.08  
Schmidtea mediterranea mk4.020020.01  
Schmidtea mediterranea mk4.002143.02  
Schmidtea mediterranea mk4.026626.01  
Schmidtea mediterranea mk4.004410.03  
Schmidtea mediterranea mk4.000546.06  
Schmidtea mediterranea mk4.000477.03  
Schmidtea mediterranea mk4.002247.10   Dynein heavy chain 2, axonemal
Schmidtea mediterranea mk4.008765.00  
Schmidtea mediterranea mk4.002247.09  
Schmidtea mediterranea mk4.000624.04  
Schmidtea mediterranea mk4.004075.01  
Schmidtea mediterranea mk4.014370.00  
Schmidtea mediterranea mk4.004458.02  
Schmidtea mediterranea mk4.054782.00  
Schmidtea mediterranea mk4.011930.00  
Schmidtea mediterranea mk4.004185.03  
Schmidtea mediterranea mk4.004185.04  
Schmidtea mediterranea mk4.015731.01  
Schmidtea mediterranea mk4.000477.05  
Schmidtea mediterranea mk4.000546.10  
Schmidtea mediterranea mk4.030484.01  
Schmidtea mediterranea mk4.013576.02  
Schmidtea mediterranea mk4.028402.00   Cytoplasmic dynein 2 heavy chain 1
Schmidtea mediterranea mk4.021976.01  
Schmidtea mediterranea mk4.004410.01  
Schmidtea mediterranea mk4.001137.01  
Schmidtea mediterranea mk4.000860.03   Dynein heavy chain, putative
Schmidtea mediterranea mk4.001126.00  
Schmidtea mediterranea mk4.015731.02  
Schmidtea mediterranea mk4.012640.01  
Schmidtea mediterranea mk4.001241.07  
Schmidtea mediterranea mk4.014193.01  
Schmidtea mediterranea mk4.011395.01  
Schmidtea mediterranea mk4.013719.00  
Schmidtea mediterranea mk4.026626.00  
Schmidtea mediterranea mk4.001137.02  
Schmidtea mediterranea mk4.001241.09  
Schmidtea mediterranea mk4.025230.00  
Schmidtea mediterranea mk4.030316.03  
Schmidtea mediterranea mk4.028402.01  
Schmidtea mediterranea mk4.001040.02  
Schmidtea mediterranea mk4.001459.04  
Schmidtea mediterranea mk4.015339.00  
Schmidtea mediterranea mk4.002247.05  
Schmidtea mediterranea mk4.019668.00  
Schmidtea mediterranea mk4.025309.00  
Schmidtea mediterranea mk4.039381.00  
Schmidtea mediterranea mk4.040090.00  
Schmidtea mediterranea mk4.015731.00  
Schmidtea mediterranea mk4.002247.06  
Schmidtea mediterranea mk4.007344.00  
Schmidtea mediterranea mk4.000860.05  
Schmidtea mediterranea mk4.000210.15  
Schmidtea mediterranea mk4.040090.01  
Schmidtea mediterranea mk4.008765.01  
Schmidtea mediterranea mk4.023648.00  
Schmidtea mediterranea mk4.052883.00  
Schmidtea mediterranea mk4.004410.04   Dynein heavy chain 8, axonemal
Schmidtea mediterranea mk4.001040.00  
Schmidtea mediterranea mk4.000546.18  
Schmidtea mediterranea mk4.004905.01  
Schmidtea mediterranea mk4.050697.00  
Schmidtea mediterranea mk4.001241.06  
Schmidtea mediterranea mk4.021976.02  
Schmidtea mediterranea mk4.001498.06  
Schmidtea mediterranea mk4.022034.00  
Schmidtea mediterranea mk4.001137.00  
Schmidtea mediterranea mk4.013576.00  
Schmidtea mediterranea mk4.000546.17  
Schmidtea mediterranea mk4.019668.01  
Schmidtea mediterranea mk4.001040.01   Dynein heavy chain 6, axonemal
Schmidtea mediterranea mk4.022223.00  
Schmidtea mediterranea mk4.014373.00  
Schmidtea mediterranea mk4.018514.00  
Schmidtea mediterranea mk4.020020.00  
Schmidtea mediterranea mk4.003665.02  
Schmidtea mediterranea mk4.011341.00  
Trypanosoma brucei gambiense Tbg972.8.2990   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.4.310   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.11.9320   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.3.580   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.7.870   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.11.12540   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.10.6530   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.11.3620   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.7.3490   dynein heavy chain, cytosolic, putative
Trypanosoma brucei gambiense Tbg972.11.2680   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg972.4.670   dynein heavy chain, putative
Trypanosoma brucei gambiense Tbg.972.2.3300   dynein heavy chain, putative
Trypanosoma brucei Tb11.v5.0698   dynein heavy chain, putative
Trypanosoma brucei Tb427tmp.01.3010   dynein heavy chain, putative
Trypanosoma brucei Tb927.3.930   dynein heavy chain, putative
Trypanosoma brucei Tb927.7.3160   Cytoplasmic dynein 1 heavy chain (DYNC1H1), putative
Trypanosoma brucei Tb927.10.5350   dynein heavy chain, putative
Trypanosoma brucei Tb927.4.560   Cytoplasmic dynein 2 heavy chain (DYNC2H1), putative
Trypanosoma brucei Tb927.8.3250   dynein heavy chain, putative
Trypanosoma brucei Tb427tmp.02.0760   dynein heavy chain, putative
Trypanosoma brucei Tb927.7.920   Inner arm dynein 5-1
Trypanosoma brucei Tb927.11.3250   dynein heavy chain, putative
Trypanosoma brucei Tb927.11.2430   Cytoplasmic dynein 2 heavy chain (DYNC2H2), putative
Trypanosoma brucei Tb927.2.5270   dynein heavy chain, putative
Trypanosoma brucei Tb927.11.11220   dynein heavy chain, putative
Trypanosoma brucei Tb11.v5.0242   dynein heavy chain, putative
Trypanosoma brucei Tb11.v5.0733   dynein heavy chain, cytosolic, putative
Trypanosoma brucei Tb11.v5.0241   dynein heavy chain, putative
Trypanosoma brucei Tb927.4.870   dynein heavy chain, putative
Trypanosoma brucei Tb927.11.8160   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_4_460   dynein heavy chain, putative
Trypanosoma congolense TcIL3000.11.8710   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_0_24770   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_4_180   dynein heavy chain, putative
Trypanosoma congolense TcIL3000.11.11870   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_3_190   dynein heavy chain, putative
Trypanosoma congolense TcIL3000.11.2240   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_10_4500   dynein heavy chain, putative
Trypanosoma congolense TcIL3000_2_1390   dynein heavy chain, putative
Trypanosoma congolense TcIL3000.11.3060   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.507801.19   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.508879.30   Inner arm dynein 5-1
Trypanosoma cruzi TcCLB.506937.40   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.511865.90   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.511819.59   dynein heavy chain, cytosolic, putative
Trypanosoma cruzi TcCLB.448567.9   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.509119.39   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.509585.10   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.507053.209   Cytoplasmic dynein 2 heavy chain (DYNC2H1), putative
Trypanosoma cruzi TcCLB.508217.9   Dynein heavy chain, axonemal
Trypanosoma cruzi TcCLB.474341.9   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.479379.9   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.506679.110   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.510533.10   Cytoplasmic dynein 1 heavy chain (DYNC1H1), putative
Trypanosoma cruzi TcCLB.508257.170   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.508831.4   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.511821.10   Cytoplasmic dynein 1 heavy chain (DYNC1H1), putative
Trypanosoma cruzi TcCLB.510437.10   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.505231.10   dynein heavy chain, putative
Trypanosoma cruzi TcCLB.509103.39   dynein heavy chain, putative
Toxoplasma gondii TGME49_235920   dynein, axonemal, heavy chain 2 family protein
Toxoplasma gondii TGME49_230830   ATPase family associated with various cellular activities (AAA) domain-containing protein
Toxoplasma gondii TGME49_309980   dynein heavy chain family protein
Toxoplasma gondii TGME49_243482   dynein heavy chain, putative
Toxoplasma gondii TGME49_203135   dynein heavy chain family protein
Toxoplasma gondii TGME49_286932   ATPase family associated with various cellular activities (AAA) domain-containing protein
Toxoplasma gondii TGME49_324000   dynein heavy chain, n-terminal region 2 protein
Toxoplasma gondii TGME49_261018   kelch repeat-containing protein
Toxoplasma gondii TGME49_249840   dynein heavy chain 2, putative
Toxoplasma gondii TGME49_306338   dynein gamma chain, flagellar outer arm, putative
Toxoplasma gondii TGME49_327400   dynein heavy chain family protein
Toxoplasma gondii TGME49_294550   dynein heavy chain
Toxoplasma gondii TGME49_327800   dynein-1-alpha heavy chain, flagellar inner arm I1 complex, putative
Theileria parva TP01_0834   hypothetical protein
Theileria parva TP01_0835   hypothetical protein
Trichomonas vaginalis TVAG_471380   dynein heavy chain, putative
Trichomonas vaginalis TVAG_105170   dynein heavy chain, putative
Trichomonas vaginalis TVAG_006480   axonemal dynein gamma heavy chain, putative
Trichomonas vaginalis TVAG_174850   dynein heavy chain, putative
Trichomonas vaginalis TVAG_497260   axonmeal dynein heavy chain, putative
Trichomonas vaginalis TVAG_034900   axonemal dynein beta heavy chain 9, putative
Trichomonas vaginalis TVAG_440130   axonemal dynein beta heavy chain, putative
Trichomonas vaginalis TVAG_032910   1 beta dynein heavy chain, putative
Trichomonas vaginalis TVAG_527520   conserved hypothetical protein
Trichomonas vaginalis TVAG_295280   dynein heavy chain, putative
Trichomonas vaginalis TVAG_013770   axonemal dynein beta heavy chain, putative
Trichomonas vaginalis TVAG_460730   axonemal heavy chain dynein type, putative
Trichomonas vaginalis TVAG_118950   dynein heavy chain, putative
Trichomonas vaginalis TVAG_410920   cytoplasmic dynein heavy chain, putative
Trichomonas vaginalis TVAG_162980   axonmeal dynein heavy chain, putative
Trichomonas vaginalis TVAG_116100   cytoplasmic dynein heavy chain, putative
Trichomonas vaginalis TVAG_603470   dynein heavy chain, putative
Trichomonas vaginalis TVAG_160330   dynein heavy chain, putative
Trichomonas vaginalis TVAG_013270   dynein heavy chain, putative
Trichomonas vaginalis TVAG_160340   cytoplasmic dynein heavy chain, putative
Trichomonas vaginalis TVAG_390180   conserved hypothetical protein
Trichomonas vaginalis TVAG_011080   axonemal dynein gamma heavy chain, putative
Trichomonas vaginalis TVAG_004750   axonemal dynein beta heavy chain 9, putative
Trichomonas vaginalis TVAG_365640   cytoplasmic dynein heavy chain, putative
Trichomonas vaginalis TVAG_432890   cytoplasmic dynein heavy chain, putative
Trichomonas vaginalis TVAG_236550   axonmeal dynein heavy chain, putative
Trichomonas vaginalis TVAG_456970   axonmeal dynein heavy chain, putative
Trichomonas vaginalis TVAG_011310   axonemal heavy chain dynein type, putative
Trichomonas vaginalis TVAG_463220   dynein heavy chain, putative

Essentiality

TcCLB.474341.9 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.2.5270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.5270 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.5270 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.0030 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0030 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0030 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.0030 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.0390 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.0390 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0390 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0390 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.3160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.3160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3160 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.3160 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.3.930 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.930 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.930 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.930 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.560 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.560 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.560 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.560 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.5350 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5350 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5350 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.0760 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0760 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0760 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.0760 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.3010 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.3010 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3010 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.3010 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.920 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.920 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.920 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.920 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.3250 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.3250 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.3250 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.3250 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.870 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.870 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.870 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.870 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T21E12.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T21E12.4 Caenorhabditis elegans larval arrest wormbase
CELE_T21E12.4 Caenorhabditis elegans slow growth wormbase
CELE_T21E12.4 Caenorhabditis elegans sterile wormbase
PBANKA_0507300 Plasmodium berghei Dispensable plasmo
PBANKA_0925400 Plasmodium berghei Essential plasmo
TGME49_306338 Toxoplasma gondii Essentiality uncertain sidik
TGME49_294550 Toxoplasma gondii Essentiality uncertain sidik
TGME49_309980 Toxoplasma gondii Essentiality uncertain sidik
TGME49_203135 Toxoplasma gondii Essentiality uncertain sidik
TGME49_249840 Toxoplasma gondii Essentiality uncertain sidik
TGME49_243482 Toxoplasma gondii Essentiality uncertain sidik
TGME49_261018 Toxoplasma gondii Essentiality uncertain sidik
TGME49_286932 Toxoplasma gondii Essentiality uncertain sidik
TGME49_230830 Toxoplasma gondii Essentiality uncertain sidik
TGME49_235920 Toxoplasma gondii Essentiality uncertain sidik
TGME49_327800 Toxoplasma gondii Essentiality uncertain sidik
TGME49_324000 Toxoplasma gondii Essentiality uncertain sidik
TGME49_327400 Toxoplasma gondii Essentiality uncertain sidik
TGME49_306338 Toxoplasma gondii Probably non-essential sidik
TGME49_294550 Toxoplasma gondii Probably non-essential sidik
TGME49_309980 Toxoplasma gondii Probably non-essential sidik
TGME49_203135 Toxoplasma gondii Probably non-essential sidik
TGME49_249840 Toxoplasma gondii Probably non-essential sidik
TGME49_243482 Toxoplasma gondii Probably non-essential sidik
TGME49_261018 Toxoplasma gondii Probably non-essential sidik
TGME49_286932 Toxoplasma gondii Probably non-essential sidik
TGME49_230830 Toxoplasma gondii Probably non-essential sidik
TGME49_235920 Toxoplasma gondii Probably non-essential sidik
TGME49_327800 Toxoplasma gondii Probably non-essential sidik
TGME49_324000 Toxoplasma gondii Probably non-essential sidik
TGME49_327400 Toxoplasma gondii Probably non-essential sidik
TGME49_306338 Toxoplasma gondii Probably essential sidik
TGME49_294550 Toxoplasma gondii Probably essential sidik
TGME49_309980 Toxoplasma gondii Probably essential sidik
TGME49_203135 Toxoplasma gondii Probably essential sidik
TGME49_249840 Toxoplasma gondii Probably essential sidik
TGME49_243482 Toxoplasma gondii Probably essential sidik
TGME49_261018 Toxoplasma gondii Probably essential sidik
TGME49_286932 Toxoplasma gondii Probably essential sidik
TGME49_230830 Toxoplasma gondii Probably essential sidik
TGME49_235920 Toxoplasma gondii Probably essential sidik
TGME49_327800 Toxoplasma gondii Probably essential sidik
TGME49_324000 Toxoplasma gondii Probably essential sidik
TGME49_327400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.474341.9 (Trypanosoma cruzi), dynein heavy chain, putative
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