Detailed view for Tbg972.10.16640

Basic information

TDR Targets ID: 544092
Trypanosoma brucei gambiense, N-myristoyl transferase, putative
Source Database / ID: 

pI: 6.6356 | Length (AA): 446 | MW (Da): 50559 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01233   Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
PF02799   Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004379   glycylpeptide N-tetradecanoyltransferase activity  
GO:0006499   N-terminal protein myristoylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 446 2p6e (A) 21 455 39.00 0 1 1.2789 -0.47
9 446 4c7i (A) 12 421 59.00 0 1 1.67176 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127597)

Species Accession Gene Product
Arabidopsis thaliana AT5G57020   glycylpeptide N-tetradecanoyltransferase 1
Babesia bovis BBOV_III010870   myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain containing protein
Brugia malayi Bm1_22900   N-myristoyltransferase 2
Candida albicans CaO19.12111   myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C)
Candida albicans CaO19.4641   myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C)
Caenorhabditis elegans CELE_T17E9.2   Protein NMT-1, isoform C
Cryptosporidium hominis Chro.30047   N-myristoyltransferase
Cryptosporidium parvum cgd3_320   N-myristoyltransferase
Dictyostelium discoideum DDB_G0275863   glycylpeptide N-tetradecanoyltransferase
Drosophila melanogaster Dmel_CG7436   N-myristoyl transferase
Echinococcus granulosus EgrG_000721200   glycylpeptide N tetradecanoyltransferase
Entamoeba histolytica EHI_159730   glycylpeptide N-tetradecanoyltransferase, putative
Echinococcus multilocularis EmuJ_000721200   glycylpeptide N tetradecanoyltransferase
Giardia lamblia GL50803_5772   CDC72
Homo sapiens ENSG00000136448   N-myristoyltransferase 1
Homo sapiens ENSG00000152465   N-myristoyltransferase 2
Leishmania braziliensis LbrM.32.0130   N-myristoyl transferase, putative
Leishmania donovani LdBPK_320080.1   N-myristoyltransferase
Leishmania infantum LinJ.32.0080   N-myristoyltransferase
Leishmania major LmjF.32.0080   N-myristoyl transferase, putative
Leishmania mexicana LmxM.31.0080   N-myristoyl transferase, putative
Loa Loa (eye worm) LOAG_05681   N-myristoyltransferase 2
Mus musculus ENSMUSG00000020936   N-myristoyltransferase 1
Mus musculus ENSMUSG00000026643   N-myristoyltransferase 2
Neospora caninum NCLIV_003570   hypothetical protein
Oryza sativa 4327681   Os01g0708100
Plasmodium berghei PBANKA_1029800   glycylpeptide N-tetradecanoyltransferase, putative
Plasmodium falciparum PF3D7_1412800   glycylpeptide N-tetradecanoyltransferase
Plasmodium knowlesi PKNH_1345500   glycylpeptide N-tetradecanoyltransferase, putative
Plasmodium vivax PVX_085815   glycylpeptide N-tetradecanoyltransferase, putative
Plasmodium yoelii PY01548   N-myristoyltransferase
Saccharomyces cerevisiae YLR195C   glycylpeptide N-tetradecanoyltransferase NMT1
Schistosoma japonicum Sjp_0091180   ko:K00671 glycylpeptide N-tetradecanoyltransferase [EC2.3.1.97], putative
Schistosoma mansoni Smp_121420   N-myristoyltransferase
Schmidtea mediterranea mk4.008289.00   Probable glycylpeptide N-tetradecanoyltransferase
Schmidtea mediterranea mk4.002876.04   Probable glycylpeptide N-tetradecanoyltransferase
Trypanosoma brucei gambiense Tbg972.10.16640   N-myristoyl transferase, putative
Trypanosoma brucei Tb927.10.14240   N-myristoyltransferase
Trypanosoma brucei Tb11.v5.0859   N-myristoyl transferase, putative
Trypanosoma congolense TcIL3000_10_12130   N-myristoyl transferase, putative
Trypanosoma cruzi TcCLB.511283.90   N-myristoyl transferase, putative
Trypanosoma cruzi TcCLB.506525.80   N-myristoyl transferase, putative
Theileria parva TP02_0057   N-myristoyltransferase, putative
Trichomonas vaginalis TVAG_021230   N-myristoyl transferase, putative

Essentiality

Tbg972.10.16640 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14240 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14240 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14240 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14240 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T17E9.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_T17E9.2 Caenorhabditis elegans larval arrest wormbase
CELE_T17E9.2 Caenorhabditis elegans larval lethal wormbase
CELE_T17E9.2 Caenorhabditis elegans slow growth wormbase
CELE_T17E9.2 Caenorhabditis elegans sterile wormbase
YLR195C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1029800 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens N-myristoyltransferase 2 Compounds References
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Compounds References
Saccharomyces cerevisiae glycylpeptide N-tetradecanoyltransferase NMT1 Compounds References
Leishmania major N-myristoyl transferase, putative Compounds References
Homo sapiens N-myristoyltransferase 1 Compounds References
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tbg972.10.16640 (Trypanosoma brucei gambiense), N-myristoyl transferase, putative
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