pI: 7.0474 |
Length (AA): 838 |
MW (Da): 94631 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 764 | 3hnc (B) | 1 | 742 | 60.00 | 0 | 1 | 1.70663 | -1.4 |
23 | 819 | 1zyz (A) | 18 | 793 | 61.00 | 0 | 1 | 1.68187 | -1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126839)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G21790 | ribonucleoside-diphosphate reductase large subunit |
Babesia bovis | BBOV_I004870 | ribonucleoside-diphosphate reductase large chain |
Brugia malayi | Bm1_17945 | ribonucleoside-diphosphate reductase large chain, putative |
Candida albicans | CaO19.13267 | one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C) |
Candida albicans | CaO19.13201 | one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C) |
Candida albicans | CaO19.5779 | one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C) |
Candida albicans | CaO19.5845 | one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C) |
Caenorhabditis elegans | CELE_T23G5.1 | Protein RNR-1 |
Cryptosporidium hominis | Chro.60230 | ribonucleoside-diphosphate reductase large chain (ribonucleotide reductase R1 subunit) |
Cryptosporidium parvum | cgd6_1950 | ribonucleotide-diphosphate reductase large chain; RIR1; c-terminal PFL-like glycyl radical enzymes-like fold |
Chlamydia trachomatis | CT_827 | ribonucleoside-diphosphate reductase subunit alpha |
Dictyostelium discoideum | DDB_G0284071 | ribonucleoside-diphosphate reductase |
Drosophila melanogaster | Dmel_CG5371 | Ribonucleoside diphosphate reductase large subunit |
Escherichia coli | b2234 | ribonucleoside-diphosphate reductase 1, alpha subunit |
Escherichia coli | b2675 | ribonucleoside-diphosphate reductase 2, alpha subunit |
Echinococcus granulosus | EgrG_000823000 | ribonucleoside diphosphate reductase large |
Echinococcus multilocularis | EmuJ_000823000 | ribonucleoside diphosphate reductase large |
Homo sapiens | ENSG00000167325 | ribonucleotide reductase M1 |
Leishmania braziliensis | LbrM.28.0960 | ribonucleoside-diphosphate reductase large chain, putative |
Leishmania donovani | LdBPK_280980.1 | ribonucleoside-diphosphate reductase large chain, putative |
Leishmania infantum | LinJ.28.0980 | ribonucleoside-diphosphate reductase large chain, putative |
Leishmania major | LmjF.28.0890 | ribonucleoside-diphosphate reductase large chain, putative |
Leishmania mexicana | LmxM.28.0890 | ribonucleoside-diphosphate reductase large chain, putative |
Loa Loa (eye worm) | LOAG_00652 | ribonucleoside-diphosphate reductase large subunit |
Mycobacterium leprae | ML1734c | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) |
Mus musculus | ENSMUSG00000030978 | ribonucleotide reductase M1 |
Mycobacterium tuberculosis | Rv3051c | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) |
Mycobacterium tuberculosis | Rv0570 | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) |
Mycobacterium ulcerans | MUL_1878 | ribonucleotide-diphosphate reductase subunit alpha |
Neospora caninum | NCLIV_001550 | ribonucleoside-diphosphate reductase, large subunit, putative |
Oryza sativa | 4340258 | Os06g0168600 |
Oryza sativa | 4331059 | Os02g0804900 |
Plasmodium berghei | PBANKA_0611600 | ribonucleoside-diphosphate reductase large subunit, putative |
Plasmodium falciparum | PF3D7_1437200 | ribonucleoside-diphosphate reductase large subunit, putative |
Plasmodium knowlesi | PKNH_0423900 | ribonucleoside-diphosphate reductase large subunit, putative |
Plasmodium vivax | PVX_084685 | ribonucleoside-diphosphate reductase large chain, putative |
Plasmodium yoelii | PY03473 | ribonucleoside-diphosphate reductase large chain |
Saccharomyces cerevisiae | YER070W | ribonucleotide-diphosphate reductase subunit RNR1 |
Saccharomyces cerevisiae | YIL066C | ribonucleotide-diphosphate reductase subunit RNR3 |
Schistosoma japonicum | Sjp_0068740 | ko:K00525 ribonucleoside-diphosphate reductase alpha chain [EC1.17.4.1A], putative |
Schistosoma mansoni | Smp_009030 | ribonucleoside-diphosphate reductase alpha subunit |
Schmidtea mediterranea | mk4.006528.00 | Ribonucleoside-diphosphate reductase large subunit |
Schmidtea mediterranea | mk4.034835.00 | Ribonucleoside-diphosphate reductase large subunit |
Trypanosoma brucei gambiense | Tbg972.11.8940 | ribonucleoside-diphosphate reductase large chain |
Trypanosoma brucei | Tb927.11.7840 | ribonucleoside-diphosphate reductase large chain |
Trypanosoma congolense | TcIL3000_0_44200 | ribonucleoside-diphosphate reductase large chain |
Trypanosoma congolense | TcIL3000.11.8380 | ribonucleoside-diphosphate reductase large chain |
Trypanosoma cruzi | TcCLB.506933.20 | ribonucleoside-diphosphate reductase large chain, putative |
Toxoplasma gondii | TGME49_294640 | ribonucleoside-diphosphate reductase large chain |
Treponema pallidum | TP1008 | ribonucleotide-diphosphate reductase subunit alpha |
Theileria parva | TP03_0528 | ribonucleotide-diphosphate reductase large subunit, putative |
Trichomonas vaginalis | TVAG_402580 | ribonucleoside-diphosphate reductase alpha chain, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0695 | ribonucleotide-diphosphate reductase subunit alpha |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3104 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.02.5720 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5720 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5720 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.5720 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2234 | Escherichia coli | essential | goodall |
b2675 | Escherichia coli | non-essential | goodall |
CELE_T23G5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T23G5.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T23G5.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T23G5.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T23G5.1 | Caenorhabditis elegans | sterile | wormbase |
YER070W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0611600 | Plasmodium berghei | Essential | plasmo |
TGME49_294640 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | Compounds | References |
Homo sapiens | ribonucleotide reductase M1 | Compounds | References |
Herpes simplex virus (type 1 / strain 17) | Ribonucleoside-diphosphate reductase large chain | Compounds | References |
Mus musculus | ribonucleotide reductase M1 | Compounds | References |