Detailed view for Tbg972.10.8500

Basic information

TDR Targets ID: 544822
Trypanosoma brucei gambiense, dipeptidyl-peptidase 8-like serine protease
Source Database / ID: 

pI: 6.4434 | Length (AA): 850 | MW (Da): 93827 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00326   Prolyl oligopeptidase family
PF00930   Dipeptidyl peptidase IV (DPP IV) N-terminal region

Gene Ontology

Mouse over links to read term descriptions.
GO:0008236   serine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
96 846 2ecf (A) 108 739 29.00 0 1 0.871929 1.2
577 729 2o2g (A) 16 151 19.00 0 0.37 0.2891 -0.18
601 728 3o4h (A) 361 474 38.00 0.000043 1 0.447988 -0.09
654 843 1orv (A) 585 757 31.00 0 0.71 0.475629 0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129743)

Species Accession Gene Product
Arabidopsis thaliana AT5G24260   prolyl oligopeptidase family protein
Brugia malayi Bm1_55365   prolyl oligopeptidase family protein
Caenorhabditis elegans CELE_K02F2.1   Protein DPF-3, isoform A
Dictyostelium discoideum DDB_G0281415   hypothetical protein
Drosophila melanogaster Dmel_CG3744   CG3744 gene product from transcript CG3744-RG
Echinococcus granulosus EgrG_000362100   Dipeptidyl peptidase 9
Echinococcus multilocularis EmuJ_000362100   Dipeptidyl peptidase 9
Homo sapiens ENSG00000142002   dipeptidyl-peptidase 9
Homo sapiens ENSG00000074603   dipeptidyl-peptidase 8
Leishmania braziliensis LbrM.35.2630   dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B
Leishmania donovani LdBPK_362550.1   serine peptidase, Clan SC, Family S9B
Leishmania infantum LinJ.36.2550   dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B
Leishmania major LmjF.36.2420   dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B
Leishmania mexicana LmxM.36.2420   dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B
Loa Loa (eye worm) LOAG_00349   hypothetical protein
Mus musculus ENSMUSG00000032393   dipeptidylpeptidase 8
Mus musculus ENSMUSG00000001229   dipeptidylpeptidase 9
Oryza sativa 4329059   Os02g0290600
Schistosoma japonicum Sjp_0049200   ko:K08656 dipeptidyl-peptidase 9, putative
Schistosoma mansoni Smp_127840   dipeptidyl-peptidase 9 (S09 family)
Schmidtea mediterranea mk4.014226.00   Dipeptidyl-peptidase 9
Schmidtea mediterranea mk4.014100.01   Dipeptidyl-peptidase 9
Schmidtea mediterranea mk4.002699.00  
Trypanosoma brucei gambiense Tbg972.10.8500   dipeptidyl-peptidase 8-like serine protease
Trypanosoma brucei Tb927.10.6970   serine peptidase, Clan SC, Family S9B
Trypanosoma brucei Tb927.10.6940   Dipeptidyl-peptidase 8-like, putative
Trypanosoma cruzi TcCLB.503637.30   dipeptidyl-peptidase 8-like serine peptidase
Trypanosoma cruzi TcCLB.510183.20   serine peptidase, Clan SC, Family S9B

Essentiality

Tbg972.10.8500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6970 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6970 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6970 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.6970 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens dipeptidyl-peptidase 9 Compounds References
Homo sapiens dipeptidyl-peptidase 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tbg972.10.8500 (Trypanosoma brucei gambiense), dipeptidyl-peptidase 8-like serine protease
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