Detailed view for PF3D7_1241900

Basic information

TDR Targets ID: 5457
Plasmodium falciparum, tetratricopeptide repeat protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.4836 | Length (AA): 676 | MW (Da): 79801 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07719   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0008150   biological_process  
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
440 632 1ihg (A) 170 365 21.00 0.0000000042 1 0.38 0.61
502 621 1elw (A) 2 118 25.00 0.0000000016 1 0.61 -1.25
489 632 4j8f (A) 406 550 26.00 0.016 1 0.566318 -0.69
502 621 2fbn (A) 36 171 32.00 0.06 0.94 0.552815 -1.07
503 616 1na3 (A) 3 76 43.00 0.58 0.71 0.0589391 0.55
543 634 3q49 (B) 63 154 18.00 0.56 0.33 0.462895 -1.47
578 676 4gyw (A) 354 450 15.00 0.068 0.06 0.36015 -1.12
589 676 2pl2 (A) 122 206 12.00 0.86 0.04 0.280878 -0.91
52 235 4uos (A) 2 184 13.00 0.73 0.01 0.535146 -1.55
464 621 1p5q (A) 252 423 25.00 0.035 1 0.51169 -0.53
480 599 2fbn (A) 36 171 32.00 0.058 0.94 0.558686 -1.07
481 594 1na3 (A) 3 76 43.00 0.56 0.71 0.0645119 0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, sporozoite, early ring, early trophozoite, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, early schizont, late ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128799)

Species Accession Gene Product
Arabidopsis thaliana AT4G30480   tetratricopeptide repeat domain-containing protein
Babesia bovis BBOV_IV002190   hypothetical protein
Babesia bovis BBOV_IV002150   Tetratricopeptide repeat protein 1 (TPR)
Brugia malayi Bm1_18850   TPR Domain containing protein
Caenorhabditis elegans CELE_C34B2.5   Protein C34B2.5
Dictyostelium discoideum DDB_G0283677   hypothetical protein
Drosophila melanogaster Dmel_CG14894   CG14894 gene product from transcript CG14894-RB
Echinococcus granulosus EgrG_001097000   Tetratricopeptide repeat protein 1
Echinococcus multilocularis EmuJ_001097000   Tetratricopeptide repeat protein 1
Giardia lamblia GL50803_5949   Tetratricopeptide repeat protein
Homo sapiens ENSG00000113312   tetratricopeptide repeat domain 1
Leishmania braziliensis LbrM.20.3430   hypothetical protein, conserved
Leishmania donovani LdBPK_343630.1   TPR repeat, putative
Leishmania infantum LinJ.34.3630   hypothetical protein, conserved
Leishmania major LmjF.34.3820   hypothetical protein, conserved
Leishmania mexicana LmxM.33.3820   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04831   TPR Domain containing protein
Mus musculus ENSMUSG00000041278   tetratricopeptide repeat domain 1
Neospora caninum NCLIV_063670   hypothetical protein
Oryza sativa 4348950   Os10g0486900
Onchocerca volvulus OVOC1705   Tetratricopeptide repeat protein 1 homolog
Plasmodium berghei PBANKA_1455300   tetratricopeptide repeat protein, putative
Plasmodium falciparum PF3D7_1241900   tetratricopeptide repeat protein, putative
Plasmodium knowlesi PKNH_1461200   tetratricopeptide repeat protein, putative
Plasmodium vivax PVX_100995   TPR domain containing protein
Plasmodium yoelii PY01491   similar to tetratricopeptide repeat domain 1, putative
Schistosoma japonicum Sjp_0219680   Tetratricopeptide repeat protein 1, putative
Schistosoma mansoni Smp_072970   tetratricopeptide protein
Schmidtea mediterranea mk4.012819.00   Tetratricopeptide repeat protein 1
Schmidtea mediterranea mk4.010049.00   Tetratricopeptide repeat protein 1
Schmidtea mediterranea mk4.012384.01  
Trypanosoma brucei gambiense Tbg972.4.730   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.920   TPR repeat, putative
Trypanosoma congolense TcIL3000_4_530   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508257.110   TPR repeat, putative
Toxoplasma gondii TGME49_247000   tetratricopeptide repeat-containing protein
Theileria parva TP03_0434   hypothetical protein
Trichomonas vaginalis TVAG_044480   heat shock protein 70 (HSP70)-interacting protein, putative

Essentiality

PF3D7_1241900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.920 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.920 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.920 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.920 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_247000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1241900 (Plasmodium falciparum), tetratricopeptide repeat protein, putative
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