Detailed view for Tbg972.1.380

Basic information

TDR Targets ID: 546504
Trypanosoma brucei gambiense, developmentally regulated phosphoprotein
Source Database / ID: 

pI: 6.4926 | Length (AA): 420 | MW (Da): 47178 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02518   Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF10436   Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
45 419 2e0a (A) 20 365 26.00 0 1 1.12106 -0.49
52 419 2e0a (A) 30 365 31.00 0 1 1.06349 0.05
243 339 1vjl (A) 19 131 32.00 0.58 0.41 0.363252 0.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127409)

Species Accession Gene Product
Arabidopsis thaliana AT3G06483   pyruvate dehydrogenase kinase
Brugia malayi Bm1_30205   kinase, mitochondrial precursor
Candida albicans CaO19.7281   similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase
Caenorhabditis elegans CELE_ZK370.5   Protein PDHK-2
Drosophila melanogaster Dmel_CG8808   Pyruvate dehydrogenase kinase
Echinococcus granulosus EgrG_000147400   Pyruvate dehydrogenase lipoamide kinase
Echinococcus multilocularis EmuJ_000147400   Pyruvate dehydrogenase (lipoamide) kinase
Echinococcus multilocularis EmuJ_000136800   Pyruvate dehydrogenase (lipoamide) kinase
Homo sapiens ENSG00000004799   pyruvate dehydrogenase kinase, isozyme 4
Homo sapiens ENSG00000067992   pyruvate dehydrogenase kinase, isozyme 3
Homo sapiens 5163   pyruvate dehydrogenase kinase, isozyme 1
Homo sapiens ENSG00000005882   pyruvate dehydrogenase kinase, isozyme 2
Leishmania braziliensis LbrM.20.4500   developmentally regulated phosphoprotein-like protein
Leishmania donovani LdBPK_200310.1   developmentally regulated phosphoprotein-like protein
Leishmania infantum LinJ.20.0310   developmentally regulated phosphoprotein-like protein
Leishmania major LmjF.20.0280   developmentally regulated phosphoprotein-like protein
Leishmania mexicana LmxM.20.0280   developmentally regulated phosphoprotein-like protein
Loa Loa (eye worm) LOAG_02700   hypothetical protein
Mus musculus ENSMUSG00000035232   pyruvate dehydrogenase kinase, isoenzyme 3
Mus musculus ENSMUSG00000019577   pyruvate dehydrogenase kinase, isoenzyme 4
Mus musculus ENSMUSG00000006494   pyruvate dehydrogenase kinase, isoenzyme 1
Mus musculus ENSMUSG00000038967   pyruvate dehydrogenase kinase, isoenzyme 2
Oryza sativa 4344039   Os07g0637300
Oryza sativa 4332932   Os03g0370000
Schistosoma japonicum Sjp_0206730   ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative
Schistosoma japonicum Sjp_0215760   [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative
Schistosoma mansoni Smp_068170.1   pyruvate dehydrogenase
Schistosoma mansoni Smp_068170.2   pyruvate dehydrogenase
Schistosoma mansoni Smp_140580   pyruvate dehydrogenase
Schmidtea mediterranea mk4.003066.04  
Schmidtea mediterranea mk4.003066.06   Probable
Schmidtea mediterranea mk4.004229.02  
Schmidtea mediterranea mk4.003066.05  
Schmidtea mediterranea mk4.004229.01  
Trypanosoma brucei gambiense Tbg972.1.380   developmentally regulated phosphoprotein
Trypanosoma brucei Tb927.1.1000   developmentally regulated phosphoprotein
Trypanosoma congolense TcIL3000_1_420   developmentally regulated phosphoprotein, putative
Trypanosoma cruzi TcCLB.511421.110   developmentally regulated phosphoprotein, putative

Essentiality

Tbg972.1.380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.1000 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.1000 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.1000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.1000 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens pyruvate dehydrogenase kinase, isozyme 4 Compounds References
Rattus norvegicus Pyruvate dehydrogenase kinase Compounds References
Homo sapiens pyruvate dehydrogenase kinase, isozyme 1 Compounds References
Homo sapiens pyruvate dehydrogenase kinase, isozyme 3 Compounds References
Homo sapiens pyruvate dehydrogenase kinase, isozyme 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tbg972.1.380 (Trypanosoma brucei gambiense), developmentally regulated phosphoprotein
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