Detailed view for TcCLB.503599.40

Basic information

TDR Targets ID: 54687
Trypanosoma cruzi, KRI1-like family/KRI1-like family C-terminal, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.9734 | Length (AA): 996 | MW (Da): 114240 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05178   KRI1-like family
PF12936   KRI1-like family C-terminal

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
295 519 5cwq (A) 8 222 29.00 0.089 0.93 0.312104 0.37
414 542 5hmo (A) 817 924 36.00 0.16 0.11 0.144718 1.36
905 966 5k57 (A) 10 71 13.00 0 0.01 0.255449 -1.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128130)

Species Accession Gene Product
Arabidopsis thaliana AT3G24080   KRR1 family protein
Babesia bovis BBOV_II000850   hypothetical protein
Brugia malayi Bm1_44250   Krr1 family protein
Candida albicans CaO19.9177   similar to S. cerevisiae KRI1 (YNL308C) part of nucleolar complex required for 40S ribosome biogenesis
Candida albicans CaO19.1609   similar to S. cerevisiae KRI1 (YNL308C) part of nucleolar complex required for 40S ribosome biogenesis
Caenorhabditis elegans CELE_F54C9.9   Protein F54C9.9
Cryptosporidium hominis Chro.80492   hypothetical protein
Cryptosporidium parvum cgd8_4280   zz domain protein
Dictyostelium discoideum DDB_G0292468   hypothetical protein
Drosophila melanogaster Dmel_CG5645   CG5645 gene product from transcript CG5645-RA
Echinococcus granulosus EgrG_000656620   protein KRI1
Entamoeba histolytica EHI_180420   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000656620   protein KRI1
Giardia lamblia GL50803_10569   Hypothetical protein
Homo sapiens ENSG00000129347   KRI1 homolog (S. cerevisiae)
Leishmania braziliensis LbrM.27.0390   hypothetical protein, conserved
Leishmania donovani LdBPK_351100.1   KRI1-like family/KRI1-like family C-terminal, putative
Leishmania infantum LinJ.35.1100   hypothetical protein, conserved
Leishmania major LmjF.35.1090   hypothetical protein, conserved
Leishmania mexicana LmxM.34.1090   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00202   hypothetical protein
Mus musculus ENSMUSG00000035047   KRI1 homolog (S. cerevisiae)
Neospora caninum NCLIV_061330   hypothetical protein
Oryza sativa 4339161   Os05g0490000
Onchocerca volvulus OVOC10748   Protein KRI1 homolog
Plasmodium berghei PBANKA_0705100   protein KRI1, putative
Plasmodium falciparum PF3D7_0825500   protein KRI1, putative
Plasmodium knowlesi PKNH_1319500   protein KRI1, putative
Plasmodium vivax PVX_089085   protein KRI1, putative
Plasmodium yoelii PY01886   Zinc finger, ZZ type, putative
Saccharomyces cerevisiae YNL308C   Kri1p
Schistosoma japonicum Sjp_0101360   IPR007851,Krr1,domain-containing
Schistosoma japonicum Sjp_0091470   expressed protein
Schistosoma japonicum Sjp_0116270   expressed protein
Schistosoma mansoni Smp_133510   aldehyde dehydrogenase
Trypanosoma brucei gambiense Tbg972.5.1220   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.840   KRI1-like family/KRI1-like family C-terminal, putative
Trypanosoma congolense TcIL3000_0_40600   KRI1-like family C-terminal, putative
Trypanosoma congolense TcIL3000_0_37600   KRI1-like family/KRI1-like family C-terminal, putative
Trypanosoma cruzi TcCLB.505163.30   KRI1-like family/KRI1-like family C-terminal, putative
Trypanosoma cruzi TcCLB.503599.40   KRI1-like family/KRI1-like family C-terminal, putative
Toxoplasma gondii TGME49_219150   zinc finger, zz type domain-containing protein
Theileria parva TP04_0496   hypothetical protein
Trichomonas vaginalis TVAG_067860   conserved hypothetical protein

Essentiality

TcCLB.503599.40 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.840 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.840 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F54C9.9 Caenorhabditis elegans larval arrest wormbase
CELE_F54C9.9 Caenorhabditis elegans slow growth wormbase
CELE_F54C9.9 Caenorhabditis elegans sterile wormbase
YNL308C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0705100 Plasmodium berghei Essential plasmo
TGME49_219150 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.503599.40 (Trypanosoma cruzi), KRI1-like family/KRI1-like family C-terminal, putative
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