Detailed view for TcCLB.511859.200

Basic information

TDR Targets ID: 54695
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4943 | Length (AA): 364 | MW (Da): 40562 | Paralog Number: 14

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF16825   IGP family C-type lectin domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
47 125 1qdd (A) 17 95 18.00 0.61 0.04 0.067633 1.2
55 121 1e5u (I) 87 155 28.00 0.36 0.01 0.301666 1.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128854)

Species Accession Gene Product
Brugia malayi Bm1_09540   hypothetical protein
Loa Loa (eye worm) LOAG_15292   hypothetical protein
Loa Loa (eye worm) LOAG_15811   hypothetical protein
Trypanosoma brucei gambiense Tbg.972.2.3410   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.2940   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3580   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3620   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3660   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3720   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3430   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3390   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3540  
Trypanosoma brucei gambiense Tbg.972.2.3450  
Trypanosoma brucei gambiense Tbg.972.2.3330   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3490   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3500   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3520   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3600   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3350   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3700   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3740   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3640   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3470   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.2800   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3680   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3760   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3550   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg.972.2.3370   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.4760   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.4920   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5290   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5300   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5310   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5320   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5330   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5340   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5350   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.5360   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_13740   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_2_1410   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_01110   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_33420   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_27940   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_2_110   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_02000   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_01980   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_12820   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511911.90   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508945.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511053.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508637.40   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504011.80   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504533.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511129.60   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511047.70   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511859.200   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507359.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507631.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506011.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510249.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506731.10   hypothetical protein
Trypanosoma cruzi TcCLB.508735.100   hypothetical protein, conserved

Essentiality

TcCLB.511859.200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.5290 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.5290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.5290 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.4760 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4760 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4760 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.4760 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.4920 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4920 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4920 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.2.4920 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511859.200 (Trypanosoma cruzi), hypothetical protein, conserved
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