Detailed view for TcCLB.510879.110

Basic information

TDR Targets ID: 54986
Trypanosoma cruzi, ribosomal protein L3, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.6973 | Length (AA): 428 | MW (Da): 48540 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00297   Ribosomal protein L3

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126874)

Species Accession Gene Product
Arabidopsis thaliana AT1G43170   60S ribosomal protein L3-1
Arabidopsis thaliana AT1G61580   60S ribosomal protein L3-2
Babesia bovis BBOV_I002850   ribosomal protein L3, putative
Brugia malayi Bm1_13895   60S ribosomal protein L3
Candida albicans CaO19.9169   likely cytosolic ribosomal protein similar to S. cerevisiae RPL3 (YOR063W) large subunit protein L3
Candida albicans CaO19.1601   likely cytosolic ribosomal protein similar to S. cerevisiae RPL3 (YOR063W) large subunit protein L3
Caenorhabditis elegans CELE_F13B10.2   Protein RPL-3, isoform A
Cryptosporidium hominis Chro.50225   hypothetical protein
Cryptosporidium parvum cgd5_1580   hypothetical protein
Dictyostelium discoideum DDB_G0291862   60S ribosomal protein L3
Drosophila melanogaster Dmel_CG4863   Ribosomal protein L3
Echinococcus granulosus EgrG_000700700   ribosomal protein L3
Entamoeba histolytica EHI_126240   60S ribosomal protein L3, putative
Entamoeba histolytica EHI_005890   60S ribosomal protein L3, putative
Entamoeba histolytica EHI_055670   60S ribosomal protein L3, putative
Entamoeba histolytica EHI_167520   60S ribosomal protein L3, putative
Echinococcus multilocularis EmuJ_000700700   ribosomal protein L3
Giardia lamblia GL50803_16525   Ribosomal protein L3
Homo sapiens 6123   ribosomal protein L3-like
Homo sapiens ENSG00000100316   ribosomal protein L3
Leishmania infantum LinJ.32.3320   ribosomal protein L3, putative
Leishmania infantum LinJ.34.2730   ribosomal protein L3, putative
Leishmania infantum LinJ.32.3330   ribosomal protein L3, putative
Leishmania major LmjF.34.2900   ribosomal protein L3, putative
Leishmania major LmjF.34.2870   ribosomal protein L3, putative
Leishmania major LmjF.32.3130   ribosomal protein L3, putative
Leishmania major LmjF.34.2880   ribosomal protein L3, putative
Leishmania major LmjF.34.2890   ribosomal protein L3, putative
Leishmania mexicana LmxM.33.2900   ribosomal protein L3, putative
Leishmania mexicana LmxM.33.2870   ribosomal protein L3, putative
Leishmania mexicana LmxM.31.3130   ribosomal protein L3, putative
Loa Loa (eye worm) LOAG_10407   60S ribosomal protein L3
Mus musculus ENSMUSG00000002500   ribosomal protein L3-like
Mus musculus ENSMUSG00000060036   ribosomal protein L3
Mus musculus 433745   predicted gene 12816
Neospora caninum NCLIV_045800   60S ribosomal protein L3, related
Oryza sativa 4351604   Os12g0167900
Oryza sativa 4349879   Os11g0168200
Plasmodium berghei PBANKA_0511900   60S ribosomal protein L3, putative
Plasmodium falciparum PF3D7_1027800   60S ribosomal protein L3
Plasmodium knowlesi PKNH_0612200   60S ribosomal protein L3, putative
Plasmodium vivax PVX_111330   60S ribosomal protein L3, putative
Plasmodium yoelii PY05881   ribosomal protein L3, putative
Saccharomyces cerevisiae YOR063W   ribosomal 60S subunit protein L3
Schistosoma japonicum Sjp_0213900   ko:K02925 large subunit ribosomal protein L3e, putative
Schistosoma mansoni Smp_047200   60S ribosomal protein L3
Schmidtea mediterranea mk4.003495.03   60S ribosomal protein L3
Schmidtea mediterranea mk4.001411.02   60S ribosomal protein L3
Trypanosoma brucei gambiense Tbg972.4.1700   ribosomal protein L3, putative
Trypanosoma brucei gambiense Tbg972.4.1710   ribosomal protein L3, mitochondrial, putative
Trypanosoma brucei Tb927.4.1800   Mitochondrial ribosomal protein L3
Trypanosoma brucei Tb927.4.1790   ribosomal protein L3, putative
Trypanosoma congolense TcIL3000_4_1450   ribosomal protein L3, putative
Trypanosoma congolense TcIL3000_4_1440   ribosomal protein L3, mitochondrial, putative
Trypanosoma cruzi TcCLB.510879.120   ribosomal protein L3, putative
Trypanosoma cruzi TcCLB.510879.110   ribosomal protein L3, putative
Toxoplasma gondii TGME49_227360   ribosomal protein RPL3
Theileria parva TP01_0560   60S ribosomal protein L3, putative
Trichomonas vaginalis TVAG_124190   60S ribosomal protein L3, putative
Trichomonas vaginalis TVAG_071700   50S ribosomal protein L3, putative
Trichomonas vaginalis TVAG_125550   ribosomal protein L3p, putative
Trichomonas vaginalis TVAG_059650   ribosomal protein L3p, putative
Trichomonas vaginalis TVAG_013060   60S ribosomal protein L3, putative
Trichomonas vaginalis TVAG_388910   60S ribosomal protein L3, putative

Essentiality

TcCLB.510879.110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.1790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.1790 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.1790 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F13B10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F13B10.2 Caenorhabditis elegans larval arrest wormbase
CELE_F13B10.2 Caenorhabditis elegans slow growth wormbase
CELE_F13B10.2 Caenorhabditis elegans sterile wormbase
YOR063W Saccharomyces cerevisiae inviable yeastgenome
TGME49_227360 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.510879.110 (Trypanosoma cruzi), ribosomal protein L3, putative
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