pI: 6.5299 |
Length (AA): 513 |
MW (Da): 58446 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 446 | 2cg9 (A) | 262 | 677 | 43.00 | 0 | 1 | 1.2178 | 0.42 |
11 | 478 | 5tth (A) | 307 | 754 | 27.00 | 0 | 1 | 1.02488 | 0.56 |
15 | 446 | 3hjc (A) | 2 | 405 | 42.00 | 0 | 1 | 1.27941 | -0.33 |
16 | 296 | 1y6z (A) | 3 | 259 | 35.00 | 0 | 1 | 0.867058 | -0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126623)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G56030 | heat shock protein 81-2 |
Arabidopsis thaliana | AT2G04030 | chloroplast heat shock protein 90 |
Arabidopsis thaliana | AT5G52640 | heat shock protein 90.1 |
Arabidopsis thaliana | AT5G56000 | Heat shock protein 90-4 |
Arabidopsis thaliana | AT3G07770 | HEAT SHOCK PROTEIN 89.1 |
Arabidopsis thaliana | AT5G56010 | Heat shock protein 90-3 |
Arabidopsis thaliana | AT4G24190 | HSP90-like protein GRP94 |
Babesia bovis | BBOV_III004230 | hsp90 protein |
Brugia malayi | Bm1_51495 | heat shock protein 90 |
Brugia malayi | Bm1_39715 | Endoplasmin precursor |
Candida albicans | CaO19.13868 | heat shock protein |
Candida albicans | CaO19_6515 | hypothetical protein |
Candida albicans | CaO19.6515 | heat shock protein |
Caenorhabditis elegans | CELE_T05E11.3 | Protein ENPL-1, isoform B |
Caenorhabditis elegans | CELE_C47E8.5 | Protein DAF-21 |
Cryptosporidium hominis | Chro.30427 | heat shock protein 83 |
Cryptosporidium parvum | cgd3_3770 | Hsp90 |
Dictyostelium discoideum | DDB_G0280057 | heat shock protein Hsp90 family protein |
Dictyostelium discoideum | DDB_G0267400 | heat shock protein Hsp90 family protein |
Drosophila melanogaster | Dmel_CG1242 | Heat shock protein 83 |
Drosophila melanogaster | Dmel_CG5520 | Glycoprotein 93 |
Escherichia coli | b0473 | protein refolding molecular co-chaperone Hsp90, Hsp70-dependent |
Echinococcus granulosus | EgrG_000723800 | heat shock protein 90 |
Echinococcus granulosus | EgrG_000918050 | heat shock protein 90 |
Echinococcus granulosus | EgrG_001043900 | endoplasmin |
Echinococcus granulosus | EgrG_000008700 | heat shock protein heat shock protein 90 alpha |
Echinococcus granulosus | EgrG_000679700 | heat shock protein |
Entamoeba histolytica | EHI_102270 | heat shock protein 90, putative |
Entamoeba histolytica | EHI_196940 | heat shock protein 90, putative |
Echinococcus multilocularis | EmuJ_000723800 | heat shock protein 90 |
Echinococcus multilocularis | EmuJ_000008700 | heat shock protein 90 |
Echinococcus multilocularis | EmuJ_000679700 | heat shock protein |
Echinococcus multilocularis | EmuJ_001043900 | endoplasmin |
Giardia lamblia | GL50803_13864 | Heat shock protein HSP 90-alpha |
Giardia lamblia | GL50803_15247 | Grp94/Hsp90 |
Giardia lamblia | GL50803_98054 | Heat shock protein HSP 90-alpha |
Homo sapiens | ENSG00000096384 | heat shock protein 90kDa alpha (cytosolic), class B member 1 |
Homo sapiens | ENSG00000080824 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
Homo sapiens | ENSG00000166598 | heat shock protein 90kDa beta (Grp94), member 1 |
Leishmania braziliensis | LbrM.33.0340 | heat shock protein 83-1 |
Leishmania braziliensis | LbrM.33.0350 | heat shock protein 83-1 |
Leishmania braziliensis | LbrM.29.0780 | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative |
Leishmania braziliensis | LbrM.33.0330 | heat shock protein 83-1 |
Leishmania donovani | LdBPK_290790.1 | heat shock protein 90, putative |
Leishmania donovani | LdBPK_330360.1 | heat shock protein 83-1 |
Leishmania infantum | LinJ.29.0790 | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative |
Leishmania infantum | LinJ.33.0350 | heat shock protein 83-1 |
Leishmania infantum | LinJ.33.0360 | heat shock protein 83-1 |
Leishmania infantum | LinJ.33.0370 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0360 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0355 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0314 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0316 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0336 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0320 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0318 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0343 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0350 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0365 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0333 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0323 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0340 | heat shock protein 83-1 |
Leishmania major | LmjF.29.0760 | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative |
Leishmania major | LmjF.33.0330 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0312 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0326 | heat shock protein 83-1 |
Leishmania major | LmjF.33.0346 | heat shock protein 83-1 |
Leishmania mexicana | LmxM.32.0312 | heat shock protein 83-1 |
Leishmania mexicana | LmxM.08_29.0760 | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative |
Leishmania mexicana | LmxM.32.0314 | heat shock protein 83-1 |
Loa Loa (eye worm) | LOAG_04661 | endoplasmin |
Loa Loa (eye worm) | LOAG_00073 | heat shock protein 90 |
Mycobacterium leprae | ML1623 | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) |
Mus musculus | ENSMUSG00000023944 | heat shock protein 90 alpha (cytosolic), class B member 1 |
Mus musculus | ENSMUSG00000020048 | heat shock protein 90, beta (Grp94), member 1 |
Mus musculus | ENSMUSG00000021270 | heat shock protein 90, alpha (cytosolic), class A member 1 |
Mycobacterium tuberculosis | Rv2299c | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) |
Mycobacterium ulcerans | MUL_2744 | heat shock protein 90 |
Neospora caninum | NCLIV_040880 | HSP90, related |
Neospora caninum | NCLIV_019110 | HSP90-like protein, related |
Oryza sativa | 9267802 | Os09g0482610 |
Oryza sativa | 4347405 | Os09g0482400 |
Oryza sativa | 4345951 | Os08g0500700 |
Oryza sativa | 4347402 | Os09g0482100 |
Oryza sativa | 4352339 | Os12g0514500 |
Oryza sativa | 4345893 | Os08g0487800 |
Oryza sativa | 4342077 | Os06g0716700 |
Oryza sativa | 4347356 | Os09g0474300 |
Oryza sativa | 9267997 | Os04g0107900 |
Oryza sativa | 9268423 | Os09g0482300 |
Plasmodium berghei | PBANKA_0805700 | heat shock protein 90, putative |
Plasmodium falciparum | PF3D7_0708400 | heat shock protein 90 |
Plasmodium knowlesi | PKNH_1441400 | endoplasmin, putative |
Plasmodium knowlesi | PKNH_0107000 | heat shock protein 90, putative |
Plasmodium vivax | PVX_123745 | endoplasmin, putative |
Plasmodium vivax | PVX_087950 | heat shock protein 86, putative |
Plasmodium yoelii | PY00131 | putative heat shock protein 81-2 |
Plasmodium yoelii | PY00582 | heat shock protein 90 |
Plasmodium yoelii | PY00130 | heat shock 90 kDa protein homolog |
Saccharomyces cerevisiae | YPL240C | Hsp90 family chaperone HSP82 |
Saccharomyces cerevisiae | YMR186W | Hsp90 family chaperone HSC82 |
Schistosoma japonicum | Sjp_0012130 | IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing |
Schistosoma japonicum | Sjp_0309120 | Heat shock protein HSP 90-alpha, putative |
Schistosoma japonicum | Sjp_0044660 | ko:K04079 molecular chaperone HtpG, putative |
Schistosoma japonicum | Sjp_0007330 | Heat shock protein 83, putative |
Schistosoma japonicum | Sjp_0012140 | ko:K09487 heat shock protein 90kDa beta, putative |
Schistosoma japonicum | Sjp_0044670 | Heat shock protein HSP 90-beta, putative |
Schistosoma mansoni | Smp_072330.2 | heat shock protein |
Schistosoma mansoni | Smp_030300.4 | endoplasmin |
Schistosoma mansoni | Smp_072330.1 | heat shock protein |
Schistosoma mansoni | Smp_030300.3 | endoplasmin |
Schmidtea mediterranea | mk4.007838.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.017134.00 | |
Schmidtea mediterranea | mk4.005886.00 | |
Schmidtea mediterranea | mk4.007212.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.027122.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.017444.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.034899.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001495.06 | |
Schmidtea mediterranea | mk4.019240.04 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.002547.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001015.04 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.008399.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.019297.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.000497.11 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001850.04 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.021028.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.003841.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.005511.02 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001354.04 | |
Schmidtea mediterranea | mk4.019819.00 | |
Schmidtea mediterranea | mk4.000032.21 | Endoplasmin |
Schmidtea mediterranea | mk4.017004.00 | |
Schmidtea mediterranea | mk4.014745.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.002761.01 | |
Schmidtea mediterranea | mk4.008769.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.009930.00 | Putative thrombospondin |
Schmidtea mediterranea | mk4.003186.09 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001450.11 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.020174.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.008725.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.012604.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.000245.17 | |
Schmidtea mediterranea | mk4.000286.14 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.034713.00 | |
Schmidtea mediterranea | mk4.014783.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.005289.00 | |
Schmidtea mediterranea | mk4.005595.02 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.003321.03 | |
Schmidtea mediterranea | mk4.025031.00 | |
Schmidtea mediterranea | mk4.015137.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.004356.02 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.013118.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001147.04 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.010175.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.008904.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.001025.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.006109.03 | |
Schmidtea mediterranea | mk4.001553.04 | |
Schmidtea mediterranea | mk4.017122.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.035456.00 | |
Schmidtea mediterranea | mk4.002875.05 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.034823.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.000023.24 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.000326.07 | |
Schmidtea mediterranea | mk4.056471.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.017077.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.019496.00 | |
Schmidtea mediterranea | mk4.029467.00 | |
Schmidtea mediterranea | mk4.002464.00 | |
Schmidtea mediterranea | mk4.002389.02 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.007949.03 | |
Schmidtea mediterranea | mk4.003252.01 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.000729.14 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.005831.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.016373.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.015857.00 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.023244.02 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.008721.05 | Heat shock protein 90 |
Schmidtea mediterranea | mk4.008241.02 | Heat shock protein 90 |
Trypanosoma brucei gambiense | Tbg972.3.3850 | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative |
Trypanosoma brucei gambiense | Tbg972.10.13280 | heat shock protein 83,heat shock protein |
Trypanosoma brucei gambiense | Tbg972.10.13260 | Heat shock protein 83, putative |
Trypanosoma brucei gambiense | Tbg972.10.13270 | Heat shock protein 83, putative |
Trypanosoma brucei | Tb11.v5.0543 | Heat shock protein 83, putative |
Trypanosoma brucei | Tb927.10.10950 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10960 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10900 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10940 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10910 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10920 | heat shock protein, putative |
Trypanosoma brucei | Tb927.10.10980 | heat shock protein 90, putative |
Trypanosoma brucei | Tb927.10.10970 | heat shock protein, putative |
Trypanosoma brucei | Tb927.3.3580 | heat shock protein 90, putative |
Trypanosoma brucei | Tb927.10.10930 | heat shock protein, putative |
Trypanosoma congolense | TcIL3000_0_48690 | heat shock protein 90, putative |
Trypanosoma congolense | TcIL3000_0_26140 | Heat shock protein 83, putative |
Trypanosoma congolense | TcIL3000_3_2270 | heat shock protein 90, putative |
Trypanosoma cruzi | TcCLB.509643.130 | heat shock protein 85, putative |
Trypanosoma cruzi | TcCLB.506989.190 | heat shock protein 90, putative |
Trypanosoma cruzi | TcCLB.509105.140 | heat shock protein 85, putative |
Trypanosoma cruzi | TcCLB.506591.4 | heat shock protein 90, putative |
Trypanosoma cruzi | TcCLB.507713.30 | heat shock protein 85, putative |
Trypanosoma cruzi | TcCLB.509105.150 | heat shock protein 85, putative |
Trypanosoma cruzi | TcCLB.503811.10 | heat shock protein 90, putative |
Trypanosoma cruzi | TcCLB.509643.139 | Heat shock protein 83, putative |
Toxoplasma gondii | TGME49_244560 | heat shock protein 90, putative |
Toxoplasma gondii | TGME49_288380 | heat shock protein HSP90 |
Treponema pallidum | TP0984 | heat shock protein 90 |
Theileria parva | TP02_0244 | heat shock protein 90 |
Trichomonas vaginalis | TVAG_153560 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_378910 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_030810 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_034720 | heat shock protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0138 | heat shock protein 90 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2334 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.10.10980 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10980 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10980 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.10980 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.3.3580 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.3580 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.3580 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.3580 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0473 | Escherichia coli | non-essential | goodall |
CELE_C47E8.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C47E8.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C47E8.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C47E8.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C47E8.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_T05E11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05E11.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T05E11.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T05E11.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T05E11.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0805700 | Plasmodium berghei | Slow | plasmo |
TGME49_288380 | Toxoplasma gondii | Probably essential | sidik |
TGME49_244560 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | heat shock protein 90, alpha (cytosolic), class A member 1 | Compounds | References |
Saccharomyces cerevisiae | Hsp90 family chaperone HSC82 | Compounds | References |
Homo sapiens | heat shock protein 90kDa alpha (cytosolic), class B member 1 | Compounds | References |
Candida albicans | hypothetical protein | Compounds | References |
Saccharomyces cerevisiae | Hsp90 family chaperone HSP82 | Compounds | References |
Homo sapiens | heat shock protein 90kDa beta (Grp94), member 1 | Compounds | References |
Sus scrofa | Endoplasmin | Compounds | References |
Homo sapiens | heat shock protein 90kDa alpha (cytosolic), class A member 1 | Compounds | References |
Canis lupus familiaris | Heat shock protein 90 beta | Compounds | References |
Oryctolagus cuniculus | Heat shock protein HSP 90 | Compounds | References |