pI: 6.9357 |
Length (AA): 355 |
MW (Da): 40393 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 249 | 4r7y (A) | 1764 | 1962 | 42.00 | 0 | 1 | 0.768508 | 1.05 |
98 | 300 | 5cwp (A) | 21 | 229 | 26.00 | 0.23 | 1 | 0.739331 | -0.32 |
111 | 184 | 2yfa (A) | 180 | 254 | 38.00 | 0.07 | 0.72 | 0.735951 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127764)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G44900 | minichromosome maintenance protein 2 |
Babesia bovis | BBOV_II005900 | DNA replication licensing factor MCM2, putative |
Brugia malayi | Bm1_47040 | DNA replication licensing factor MCM2 |
Candida albicans | CaO19.4354 | ATP-dependent DNA helicase |
Candida albicans | CaO19.11832 | ATP-dependent DNA helicase |
Caenorhabditis elegans | CELE_Y17G7B.5 | Protein MCM-2, isoform B |
Cryptosporidium hominis | Chro.20122 | DNA replication licensing factor MCM2 |
Cryptosporidium parvum | cgd2_1100 | DNA replication licensing factor MCM2 like AAA+ ATpase |
Dictyostelium discoideum | DDB_G0286623 | MCM family protein |
Drosophila melanogaster | Dmel_CG7538 | Minichromosome maintenance 2 |
Echinococcus granulosus | EgrG_000212600 | DNA replication licensing factor MCM2 |
Entamoeba histolytica | EHI_117970 | DNA replication licensing factor |
Echinococcus multilocularis | EmuJ_000212600 | DNA replication licensing factor MCM2 |
Giardia lamblia | GL50803_15344 | MCM2 |
Homo sapiens | ENSG00000073111 | minichromosome maintenance complex component 2 |
Leishmania braziliensis | LbrM.28.0920 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania donovani | LdBPK_280940.1 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania infantum | LinJ.28.0940 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania major | LmjF.28.0850 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania mexicana | LmxM.28.0850 | minichromosome maintenance (MCM) complex subunit, putative |
Loa Loa (eye worm) | LOAG_09778 | DNA replication licensing factor MCM2 |
Mus musculus | ENSMUSG00000002870 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) |
Neospora caninum | NCLIV_052000 | DNA replication licensing factor, putative |
Oryza sativa | 4350526 | Os11g0484300 |
Plasmodium berghei | PBANKA_1024900 | DNA replication licensing factor MCM2, putative |
Plasmodium falciparum | PF3D7_1417800 | DNA replication licensing factor MCM2 |
Plasmodium knowlesi | PKNH_1340200 | DNA replication licensing factor MCM2, putative |
Plasmodium vivax | PVX_085565 | DNA replication licensing factor MCM2, putative |
Plasmodium yoelii | PY01644 | DNA replication licensing factor MCM2 |
Saccharomyces cerevisiae | YBL023C | MCM DNA helicase complex subunit MCM2 |
Schistosoma japonicum | Sjp_0072100 | DNA replication licensing factor MCM2, putative |
Schistosoma japonicum | Sjp_0072090 | ko:K02540 minichromosome maintenance protein 2, putative |
Schistosoma japonicum | Sjp_0072080 | ko:K02540 minichromosome maintenance protein 2, putative |
Schistosoma mansoni | Smp_079560 | DNA replication licensing factor MCM2 |
Schistosoma mansoni | Smp_054840 | DNA replication licensing factor MCM2 |
Schmidtea mediterranea | mk4.003649.01 | DNA replication licensing factor MCM2 |
Schmidtea mediterranea | mk4.005218.00 | DNA replication licensing factor MCM2 |
Trypanosoma brucei gambiense | Tbg972.11.8960 | minichromosome maintenance (MCM) complex subunit, putative |
Trypanosoma brucei | Tb927.11.7860 | DNA replication licensing factor MCM2 |
Trypanosoma congolense | TcIL3000.11.8400 | DNA replication licensing factor MCM2, putative |
Trypanosoma cruzi | TcCLB.506933.40 | DNA replication licensing factor MCM2, putative |
Toxoplasma gondii | TGME49_214970 | DNA replication licensing factor, putative |
Theileria parva | TP02_0532 | DNA replication licensing factor MCM2, putative |
Trichomonas vaginalis | TVAG_122470 | DNA replication licensing factor MCM4, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.5730 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5730 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5730 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.5730 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y17G7B.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y17G7B.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y17G7B.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y17G7B.5 | Caenorhabditis elegans | sterile | wormbase |
YBL023C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1024900 | Plasmodium berghei | Essential | plasmo |
TGME49_214970 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Urotensin-2 | 123 aa | 28.3% | 99 aa | Compounds | References |