pI: 8.4644 |
Length (AA): 224 |
MW (Da): 25109 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127609)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09330 | protein ECHIDNA |
Brugia malayi | Bm1_46935 | FAM18-like protein CG5021 |
Candida albicans | CaO19.4862 | C terminal eukaryotic DUF846 |
Candida albicans | CaO19.12326 | C terminal eukaryotic DUF846 |
Caenorhabditis elegans | CELE_C34D4.4 | Protein C34D4.4, isoform B |
Cryptosporidium hominis | Chro.20094 | FAM18-like protein |
Cryptosporidium parvum | cgd2_830 | conserved protein with 4x transmembrane domains |
Dictyostelium discoideum | DDB_G0276319 | hypothetical protein |
Dictyostelium discoideum | DDB_G0286703 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5021 | CG5021 gene product from transcript CG5021-RC |
Echinococcus granulosus | EgrG_001126500 | protein FAM18A |
Entamoeba histolytica | EHI_148020 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_001126500 | protein FAM18A |
Giardia lamblia | GL50803_12035 | Hypothetical protein |
Homo sapiens | ENSG00000175106 | trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) |
Homo sapiens | ENSG00000166676 | trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) |
Homo sapiens | ENSG00000171928 | trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) |
Leishmania braziliensis | LbrM.27.2050 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_271810.1 | Eukaryotic protein of unknown function (DUF846), putative |
Leishmania infantum | LinJ.27.1810 | hypothetical protein, conserved |
Leishmania major | LmjF.27.1900 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.27.1900 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00530 | hypothetical protein |
Mus musculus | ENSMUSG00000014177 | trans-golgi network vesicle protein 23B |
Mus musculus | ensembl-mmu:ENSMUSG00000050908 | trans-golgi network vesicle protein 23A |
Neospora caninum | NCLIV_005220 | hypothetical protein, conserved |
Oryza sativa | 4337877 | Os05g0159100 |
Oryza sativa | 4326837 | Os01g0331900 |
Plasmodium berghei | PBANKA_1322600 | golgi apparatus membrane protein TVP23, putative |
Plasmodium falciparum | PF3D7_1458900 | golgi apparatus membrane protein TVP23, putative |
Plasmodium knowlesi | PKNH_1222900 | golgi apparatus membrane protein TVP23, putative |
Plasmodium vivax | PVX_117515 | golgi apparatus membrane protein TVP23, putative |
Plasmodium yoelii | PY04684 | hypothetical protein |
Plasmodium yoelii | PY04685 | hypothetical protein |
Saccharomyces cerevisiae | YDR084C | Tvp23p |
Schistosoma japonicum | Sjp_0304930 | Protein FAM18A, putative |
Schistosoma mansoni | Smp_056850 | hypothetical protein |
Schmidtea mediterranea | mk4.000071.00 | Uncharacterized Golgi apparatus membrane protein-like protein |
Trypanosoma brucei gambiense | Tbg.972.2.2480 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.2.4410 | Eukaryotic protein of unknown function (DUF846), putative |
Trypanosoma congolense | TcIL3000_0_51430 | Eukaryotic protein of unknown function (DUF846), putative |
Trypanosoma congolense | TcIL3000_2_810 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509099.89 | Eukaryotic protein of unknown function (DUF846), putative |
Trypanosoma cruzi | TcCLB.509319.40 | Eukaryotic protein of unknown function (DUF846), putative |
Toxoplasma gondii | TGME49_221700 | hypothetical protein |
Trichomonas vaginalis | TVAG_403270 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.4410 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.4410 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.4410 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.4410 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_221700 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.