pI: 6.6896 |
Length (AA): 394 |
MW (Da): 44350 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126949)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G30580 | GTP-binding protein |
Arabidopsis thaliana | AT1G56050 | putative GTP-binding protein |
Babesia bovis | BBOV_III002190 | GTP-binding protein YchF domain containing protein |
Brugia malayi | Bm1_49455 | GTP-binding protein W08E3.3 |
Candida albicans | CaO19.754 | GTP-binding protein |
Candida albicans | CaO19.8374 | GTP-binding protein |
Caenorhabditis elegans | CELE_W08E3.3 | Protein OLA-1, isoform B |
Cryptosporidium hominis | Chro.10311 | GTP-binding protein |
Cryptosporidium parvum | cgd1_2760 | yyaF/YCHF TRANSFAC/OBG family small GTpase plus RNA binding domain TGS |
Chlamydia trachomatis | CT_092 | GTPase |
Dictyostelium discoideum | DDB_G0268758 | hypothetical protein |
Dictyostelium discoideum | DDB_G0292626 | hypothetical protein |
Drosophila melanogaster | Dmel_CG1354 | CG1354 gene product from transcript CG1354-RD |
Escherichia coli | b1203 | catalase inhibitor protein |
Echinococcus granulosus | EgrG_000677800 | GTP binding protein CG1354 |
Entamoeba histolytica | EHI_148270 | GTP-binding protein, putative |
Echinococcus multilocularis | EmuJ_000677800 | GTP binding protein CG1354 |
Giardia lamblia | GL50803_114246 | GTP-binding protein, putative |
Homo sapiens | ENSG00000138430 | Obg-like ATPase 1 |
Leishmania braziliensis | LbrM.27.2520 | GTP binding protein, putative |
Leishmania donovani | LdBPK_272260.1 | GTP binding protein, putative |
Leishmania infantum | LinJ.27.2260 | GTP binding protein, putative |
Leishmania major | LmjF.27.2330 | GTP binding protein, putative |
Leishmania mexicana | LmxM.27.2330 | GTP binding protein, putative |
Loa Loa (eye worm) | LOAG_01579 | GTP-binding protein |
Mycobacterium leprae | ML1936c | Probable GTP binding protein |
Mus musculus | ENSMUSG00000027108 | Obg-like ATPase 1 |
Mycobacterium tuberculosis | Rv1112 | Probable GTP binding protein |
Mycobacterium ulcerans | MUL_0166 | GTP-dependent nucleic acid-binding protein EngD |
Neospora caninum | NCLIV_051590 | GTP binding protein, putative |
Oryza sativa | 9269534 | Os03g0781000 |
Oryza sativa | 4344894 | Os08g0199300 |
Plasmodium berghei | PBANKA_0619900 | Obg-like ATPase 1, putative |
Plasmodium falciparum | PF3D7_0722400 | Obg-like ATPase 1, putative |
Plasmodium knowlesi | PKNH_0317800 | Obg-like ATPase 1, putative |
Plasmodium vivax | PVX_096235 | GTP-binding protein, putative |
Plasmodium yoelii | PY02266 | GTP-binding protein |
Saccharomyces cerevisiae | YBR025C | Ola1p |
Schistosoma japonicum | Sjp_0214350 | ko:K06942 OLA1; Obg-like ATPase 1, putative |
Schistosoma mansoni | Smp_015720 | GTP-binding protein-related |
Schmidtea mediterranea | mk4.034045.05 | |
Trypanosoma brucei gambiense | Tbg.972.2.3080 | GTP binding protein, putative |
Trypanosoma brucei | Tb927.2.5060 | GTP binding protein, putative |
Trypanosoma congolense | TcIL3000_2_1210 | GTP binding protein, putative |
Trypanosoma cruzi | TcCLB.511625.50 | GTP-binding protein, putative |
Trypanosoma cruzi | TcCLB.504741.20 | GTP-binding protein, putative |
Toxoplasma gondii | TGME49_214350 | GTP-binding protein, putative |
Treponema pallidum | TP0124 | GTP-dependent nucleic acid-binding protein EngD |
Theileria parva | TP03_0578 | GTP-binding protein, putative |
Trichomonas vaginalis | TVAG_016670 | GTP-binding protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0159 | GTP-dependent nucleic acid-binding protein EngD |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.5060 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5060 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5060 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.5060 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W08E3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_214350 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.