Detailed view for TcIL3000.11.8800

Basic information

TDR Targets ID: 552898
Trypanosoma congolense, carbonic anhydrase-like protein
Source Database / ID: 

pI: 6.7007 | Length (AA): 414 | MW (Da): 45367 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00194   Eukaryotic-type carbonic anhydrase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004089   carbonate dehydratase activity  

Metabolic Pathways

Nitrogen metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 296 3b1b (A) 24 371 24.00 0 1 0.828189 0.21
28 299 4twl (A) 3 236 21.00 0 1 0.806305 -0.07
62 273 3q31 (A) 45 246 28.00 0.000000000026 1 0.772577 -0.2
233 298 3jxg (A) 248 319 41.00 0.0012 0.4 0.40592 1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127628)

Species Accession Gene Product
Arabidopsis thaliana AT3G52720   alpha carbonic anhydrase 1
Arabidopsis thaliana AT1G08080   alpha carbonic anhydrase 7
Brugia malayi Bm1_34100   Eukaryotic-type carbonic anhydrase family protein
Brugia malayi Bm1_32535   Putative carbonic anhydrase 5 precursor
Caenorhabditis elegans CELE_K05G3.3   Protein CAH-3
Drosophila melanogaster Dmel_CG6906   Carbonic anhydrase 2
Drosophila melanogaster Dmel_CG18672   CG18672 gene product from transcript CG18672-RC
Echinococcus granulosus EgrG_000535400   carbonic anhydrase II
Echinococcus multilocularis EmuJ_000535400   carbonic anhydrase II
Homo sapiens ENSG00000168748   carbonic anhydrase VII
Homo sapiens ENSG00000104267   carbonic anhydrase II
Leishmania braziliensis LbrM.28.0490   carbonic anhydrase-like protein
Leishmania donovani LdBPK_280280.1   carbonic anhydrase-like protein
Leishmania infantum LinJ.28.0280   carbonic anhydrase-like protein
Leishmania major LmjF.28.0480   carbonic anhydrase-like protein
Leishmania mexicana LmxM.28.0480   carbonic anhydrase-like protein
Loa Loa (eye worm) LOAG_03324   eukaryotic-type carbonic anhydrase
Loa Loa (eye worm) LOAG_08956   carbonic anhydrase 3
Mus musculus ENSMUSG00000027562   carbonic anhydrase 2
Mus musculus ENSMUSG00000031883   carbonic anhydrase 7
Oryza sativa 4329556   Os02g0533300
Oryza sativa 4349804   Os11g0153200
Oryza sativa 4351529   Os12g0153500
Schistosoma japonicum Sjp_0304090   ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
Schistosoma mansoni Smp_028670.2   carbonic anhydrase II (carbonate dehydratase II)
Schistosoma mansoni Smp_028670.1   carbonic anhydrase II (carbonate dehydratase II)
Schmidtea mediterranea mk4.029768.00   Carbonic anhydrase-related protein
Schmidtea mediterranea mk4.000533.07   Carbonic anhydrase-related protein
Schmidtea mediterranea mk4.029848.00   Carbonic anhydrase-related protein
Schmidtea mediterranea mk4.002068.01   Carbonic anhydrase-related protein
Schmidtea mediterranea mk4.021301.01   Carbonic anhydrase-related protein
Schmidtea mediterranea mk4.002068.05   Carbonic anhydrase-related protein
Trypanosoma brucei gambiense Tbg972.11.9430   carbonic anhydrase-like protein
Trypanosoma brucei Tb927.11.8260   carbonic anhydrase-like protein
Trypanosoma congolense TcIL3000.11.8800   carbonic anhydrase-like protein
Trypanosoma congolense TcIL3000_0_06520   carbonic anhydrase-like protein
Trypanosoma cruzi TcCLB.508817.130   carbonic anhydrase-like protein, putative
Trypanosoma cruzi TcCLB.509597.20   carbonic anhydrase-like protein, putative

Essentiality

TcIL3000.11.8800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0290 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.0290 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus carbonic anhydrase 7 Compounds References
Stylophora pistillata Alpha carbonic anhydrase Compounds References
Stylophora pistillata Carbonic anhydrase Compounds References
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Compounds References
Homo sapiens carbonic anhydrase II Compounds References
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Compounds References
Drosophila melanogaster Carbonic anhydrase 2 Compounds References
Bos taurus Carbonic anhydrase II Compounds References
Homo sapiens carbonic anhydrase VII Compounds References
Rattus norvegicus Carbonic anhydrase II Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Astrosclera willeyana Astrosclerin-3 292 aa 24.3% 272 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcIL3000.11.8800 (Trypanosoma congolense), carbonic anhydrase-like protein
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