Detailed view for TcIL3000_0_15140

Basic information

TDR Targets ID: 556461
Trypanosoma congolense, hypothetical protein, conserved
Source Database / ID: 

pI: 7.5435 | Length (AA): 327 | MW (Da): 37129 | Paralog Number: 32

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
183 279 1tac (A) 3 84 32.00 0.21 0.09 0.398236 0.33
244 309 2kr0 (A) 198 261 22.00 0.24 0.01 0.411535 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131136)

Species Accession Gene Product
Schmidtea mediterranea mk4.026469.00  
Trypanosoma congolense TcIL3000_0_32490   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_5_5270   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_43150   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_05140   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_05150   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_00960   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_51990   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_01020   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_03960   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_28590   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_32470   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_60610   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_22730   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_09780   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_60670   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_24280   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_53060   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_56230   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_45210   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_19560   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_11170   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_60630   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_26050   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_28190   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_46440   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_27030   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_29610   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_15140   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_14360   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_09280   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_1_80   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_24320   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_60720   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)(HIV-1) Human immunodeficiency virus type 1 Tat protein 86 aa 24.7% 77 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcIL3000_0_15140 (Trypanosoma congolense), hypothetical protein, conserved
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