pI: 7.1192 |
Length (AA): 420 |
MW (Da): 44897 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 419 | 16pk (A) | 5 | 419 | 82.00 | 0 | 1 | 2.0388 | -1.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126776)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G12780 | phosphoglycerate kinase 1 |
Arabidopsis thaliana | AT1G56190 | phosphoglycerate kinase |
Arabidopsis thaliana | AT1G79550 | phosphoglycerate kinase |
Babesia bovis | BBOV_IV008070 | phosphoglycerate kinase |
Brugia malayi | Bm1_01925 | Phosphoglycerate kinase |
Candida albicans | CaO19.11135 | 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) |
Candida albicans | CaO19.3651 | 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) |
Caenorhabditis elegans | CELE_T03F1.3 | Protein PGK-1 |
Cryptosporidium hominis | Chro.70113 | phosphoglycerate kinase |
Cryptosporidium parvum | cgd7_910 | phosphoglycerate kinase 1 |
Chlamydia trachomatis | CT_693 | phosphoglycerate kinase |
Dictyostelium discoideum | DDB_G0287595 | calmodulin-binding protein |
Drosophila melanogaster | Dmel_CG3127 | Phosphoglycerate kinase |
Drosophila melanogaster | Dmel_CG9961 | CG9961 gene product from transcript CG9961-RB |
Escherichia coli | b2926 | phosphoglycerate kinase |
Echinococcus granulosus | EgrG_001043100 | phosphoglycerate kinase 1 |
Entamoeba histolytica | EHI_188180 | phosphoglycerate kinase, putative |
Echinococcus multilocularis | EmuJ_001043100 | phosphoglycerate kinase 1 |
Giardia lamblia | GL50803_90872 | Phosphoglycerate kinase |
Homo sapiens | 5232 | phosphoglycerate kinase 2 |
Homo sapiens | 5230 | phosphoglycerate kinase 1 |
Leishmania braziliensis | LbrM.20.4190 | PGKC, phosphoglycerate kinase C |
Leishmania donovani | LdBPK_200110.1 | phosphoglycerate kinase C, glycosomal |
Leishmania infantum | LinJ.20.0110 | phosphoglycerate kinase C, glycosomal |
Leishmania infantum | LinJ.20.0120 | phosphoglycerate kinase B, cytosolic |
Leishmania major | LmjF.20.0100 | phosphoglycerate kinase C, glycosomal |
Leishmania major | LmjF.20.0110 | phosphoglycerate kinase B, cytosolic |
Leishmania mexicana | LmxM.20.0100 | phosphoglycerate kinase C, glycosomal |
Leishmania mexicana | LmxM.20.0110 | phosphoglycerate kinase B, cytosolic |
Loa Loa (eye worm) | LOAG_06198 | hypothetical protein |
Mycobacterium leprae | ML0571 | Probable phosphoglycerate kinase Pgk |
Mus musculus | ENSMUSG00000062070 | phosphoglycerate kinase 1 |
Mus musculus | ENSMUSG00000031233 | phosphoglycerate kinase 2 |
Mycobacterium tuberculosis | Rv1437 | Probable phosphoglycerate kinase Pgk |
Mycobacterium ulcerans | MUL_1829 | phosphoglycerate kinase |
Neospora caninum | NCLIV_011270 | hypothetical protein |
Neospora caninum | NCLIV_005420 | Phosphoglycerate kinase (EC 2.7.2.3), related |
Oryza sativa | 4341792 | Os06g0668200 |
Oryza sativa | 4328435 | Os02g0169300 |
Plasmodium berghei | PBANKA_0823400 | phosphoglycerate kinase, putative |
Plasmodium falciparum | PF3D7_0922500 | phosphoglycerate kinase |
Plasmodium knowlesi | PKNH_0720500 | phosphoglycerate kinase, putative |
Plasmodium vivax | PVX_099535 | phosphoglycerate kinase, putative |
Plasmodium yoelii | PY04547 | phosphoglycerate kinase |
Saccharomyces cerevisiae | YCR012W | phosphoglycerate kinase |
Schistosoma japonicum | Sjp_0031010 | ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative |
Schistosoma mansoni | Smp_187370 | phosphoglycerate kinase |
Schistosoma mansoni | Smp_018890 | phosphoglycerate kinase |
Schmidtea mediterranea | mk4.005913.01 | |
Schmidtea mediterranea | mk4.003849.03 | Probable phosphoglycerate kinase |
Schmidtea mediterranea | mk4.005913.00 | Phosphoglycerate kinase |
Trypanosoma brucei gambiense | Tbg972.1.150 | phosphoglycerate kinase, putative |
Trypanosoma brucei gambiense | Tbg972.1.140 | phosphoglycerate kinase, putative |
Trypanosoma brucei | Tb927.1.700 | phosphoglycerate kinase |
Trypanosoma brucei | Tb927.1.710 | phosphoglycerate kinase |
Trypanosoma congolense | TcIL3000_1_220 | phosphoglycerate kinase |
Trypanosoma congolense | TcIL3000_0_37920 | phosphoglycerate kinase |
Trypanosoma congolense | TcIL3000_1_230 | phosphoglycerate kinase, putative |
Trypanosoma cruzi | TcCLB.505999.90 | phosphoglycerate kinase, putative |
Trypanosoma cruzi | TcCLB.511419.40 | phosphoglycerate kinase, putative |
Toxoplasma gondii | TGME49_222020 | phosphoglycerate kinase PGKII |
Toxoplasma gondii | TGME49_318230 | phosphoglycerate kinase PGKI |
Treponema pallidum | TP0538 | phosphoglycerate kinase |
Theileria parva | TP01_0965 | phosphoglycerate kinase, putative |
Trichomonas vaginalis | TVAG_268050 | phosphoglycerate kinase, putative |
Trichomonas vaginalis | TVAG_383940 | phosphoglycerate kinase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0684 | phosphoglycerate kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1460 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.1.710 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.710 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.710 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.710 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.1.700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.700 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.700 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2926 | Escherichia coli | essential | goodall |
YCR012W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0823400 | Plasmodium berghei | Essential | plasmo |
TGME49_318230 | Toxoplasma gondii | Probably essential | sidik |
TGME49_222020 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma brucei gambiense | phosphoglycerate kinase, putative | Compounds | References |
Trypanosoma brucei | phosphoglycerate kinase | Compounds | References |
Homo sapiens | phosphoglycerate kinase 2 | Compounds | References |
Homo sapiens | phosphoglycerate kinase 1 | Compounds | References |
Saccharomyces cerevisiae | phosphoglycerate kinase | Compounds | References |