pI: 8.6313 |
Length (AA): 295 |
MW (Da): 32215 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127772)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G28510 | prohibitin 1 |
Arabidopsis thaliana | AT1G03860 | prohibitin 2 |
Arabidopsis thaliana | AT5G44140 | prohibitin 7 |
Arabidopsis thaliana | AT2G20530 | prohibitin 6 |
Babesia bovis | BBOV_I004460 | prohibitin, putative |
Brugia malayi | Bm1_18290 | Hypothetical 31.8 kDa protein in chromosome II, putative |
Candida albicans | CaO19.5973 | similar to S. cerevisiae PHB2 (YGR231C) possible mitochondrial chaperone that affects mitochondrial segregation. |
Candida albicans | CaO19.13394 | similar to S. cerevisiae PHB2 (YGR231C) possible mitochondrial chaperone that affects mitochondrial segregation. |
Caenorhabditis elegans | CELE_T24H7.1 | Protein PHB-2 |
Cryptosporidium hominis | Chro.50147 | SPFH domain / Band 7 family |
Cryptosporidium parvum | cgd5_2320 | putative prohibitin with PHB domain |
Dictyostelium discoideum | DDB_G0284117 | hypothetical protein |
Drosophila melanogaster | Dmel_CG15081 | Prohibitin 2 |
Echinococcus granulosus | EgrG_000435200 | prohibitin |
Echinococcus multilocularis | EmuJ_000435200 | prohibitin |
Homo sapiens | ENSG00000215021 | prohibitin 2 |
Leishmania braziliensis | LbrM.34.0110 | prohibitin, putative |
Leishmania donovani | LdBPK_350070.1 | prohibitin, putative |
Leishmania infantum | LinJ.35.0070 | prohibitin, putative |
Leishmania major | LmjF.35.0070 | prohibitin, putative |
Leishmania mexicana | LmxM.34.0070 | prohibitin, putative |
Loa Loa (eye worm) | LOAG_08798 | hypothetical protein |
Mus musculus | ENSMUSG00000004264 | prohibitin 2 |
Neospora caninum | NCLIV_032910 | hypothetical protein |
Oryza sativa | 4334737 | Os03g0841700 |
Oryza sativa | 4342874 | Os07g0262200 |
Plasmodium berghei | PBANKA_1213100 | prohibitin, putative |
Plasmodium falciparum | PF3D7_1014700 | prohibitin, putative |
Plasmodium knowlesi | PKNH_0814800 | prohibitin, putative |
Plasmodium vivax | PVX_094950 | prohibitin, putative |
Plasmodium yoelii | PY07442 | SPFH domain / Band 7 family, putative |
Saccharomyces cerevisiae | YGR231C | prohibitin subunit PHB2 |
Schistosoma japonicum | Sjp_0095920 | Prohibitin-2, putative |
Schistosoma mansoni | Smp_075210.1 | prohibitin |
Schistosoma mansoni | Smp_075210.2 | prohibitin |
Schmidtea mediterranea | mk4.001779.01 | Prohibitin-1 |
Trypanosoma brucei gambiense | Tbg972.10.5350 | prohibitin, putative |
Trypanosoma brucei | Tb10.v4.0045 | prohibitin, putative |
Trypanosoma brucei | Tb927.10.4310 | prohibitin 2, putative |
Trypanosoma congolense | TcIL3000_10_3600 | prohibitin, putative |
Trypanosoma cruzi | TcCLB.511469.70 | prohibitin, putative |
Trypanosoma cruzi | TcCLB.506295.130 | prohibitin, putative |
Toxoplasma gondii | TGME49_233100 | SPFH domain / Band 7 family protein |
Theileria parva | TP01_0188 | prohibitin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T24H7.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T24H7.1 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1213100 | Plasmodium berghei | Essential | plasmo |
TGME49_233100 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.