pI: 5.4538 |
Length (AA): 740 |
MW (Da): 84340 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127970)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G56150 | eukaryotic translation initiation factor 3 subunit C |
Arabidopsis thaliana | AT3G22860 | eukaryotic translation initiation factor 3 subunit C2 |
Babesia bovis | BBOV_III008380 | eukaryotic translation initiation factor 3 subunit 8, putative |
Brugia malayi | Bm1_08520 | eukaryotic translation initiation factor 3 subunit 8, putative |
Candida albicans | CaO19.12105 | subunit of translation initiation complex eIF3 |
Candida albicans | CaO19.4635 | subunit of translation initiation complex eIF3 |
Caenorhabditis elegans | CELE_T23D8.4 | Protein EIF-3.C |
Cryptosporidium hominis | Chro.40430 | eukaryotic translation initiation factor 3 subunit 8 |
Cryptosporidium parvum | cgd4_3770 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0279109 | eIF-3 p110 |
Drosophila melanogaster | Dmel_CG4954 | CG4954 gene product from transcript CG4954-RB |
Echinococcus granulosus | EgrG_000128100 | eukaryotic translation initiation factor 3 |
Entamoeba histolytica | EHI_140610 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000128100 | eukaryotic translation initiation factor 3 |
Homo sapiens | ENSG00000205609 | eukaryotic translation initiation factor 3, subunit C-like |
Homo sapiens | ENSG00000184110 | eukaryotic translation initiation factor 3, subunit C |
Leishmania braziliensis | LbrM.35.7360 | eukaryotic translation initiation factor 3 subunit 8, putative |
Leishmania donovani | LdBPK_367320.1 | eukaryotic translation initiation factor 3 subunit c |
Leishmania infantum | LinJ.36.7320 | eukaryotic translation initiation factor 3 subunit 8, putative |
Leishmania major | LmjF.36.6980 | eukaryotic translation initiation factor 3 subunit 8, putative |
Leishmania mexicana | LmxM.36.6980 | eukaryotic translation initiation factor 3 subunit 8, putative |
Loa Loa (eye worm) | LOAG_01539 | eukaryotic translation initiation factor 3 subunit 8 |
Mus musculus | ENSMUSG00000030738 | eukaryotic translation initiation factor 3, subunit C |
Neospora caninum | NCLIV_001520 | Eukaryotic translation initiation factor 3 subunit C, related |
Oryza sativa | 4328137 | Os02g0123300 |
Oryza sativa | 4342306 | Os07g0124500 |
Plasmodium berghei | PBANKA_0604800 | eukaryotic translation initiation factor 3 subunit C, putative |
Plasmodium falciparum | PF3D7_1206200 | eukaryotic translation initiation factor 3 subunit C, putative |
Plasmodium knowlesi | PKNH_1305900 | eukaryotic translation initiation factor 3 subunit C, putative |
Plasmodium vivax | PVX_084345 | eukaryotic translation initiation factor 3 subunit 8, putative |
Plasmodium yoelii | PY00916 | eukaryotic translation initiation factor 3 subunit 8 |
Saccharomyces cerevisiae | YMR309C | Nip1p |
Schistosoma japonicum | Sjp_0219750 | Eukaryotic translation initiation factor 3 subunit C, putative |
Schistosoma mansoni | Smp_000480 | eukaryotic translation initiation factor 3 subunit 8 |
Schmidtea mediterranea | mk4.000093.09 | Eukaryotic translation initiation factor 3 subunit C |
Schmidtea mediterranea | mk4.000093.11 | Eukaryotic translation initiation factor 3 subunit C |
Schmidtea mediterranea | mk4.000105.02 | Eukaryotic translation initiation factor 3 subunit C |
Schmidtea mediterranea | mk4.000105.03 | |
Trypanosoma brucei gambiense | Tbg972.10.10100 | |
Trypanosoma brucei | Tb927.10.8270 | eukaryotic translation initiation factor 3 subunit c |
Trypanosoma brucei | Tb927.10.8290 | eukaryotic translation initiation factor 3 subunit c |
Trypanosoma brucei | Tb11.v5.0877 | eukaryotic translation initiation factor 3 subunit 8, putative |
Trypanosoma congolense | TcIL3000_10_7150 | eukaryotic translation initiation factor 3 subunit c |
Trypanosoma cruzi | TcCLB.507723.130 | eukaryotic translation initiation factor 3 subunit c |
Trypanosoma cruzi | TcCLB.507611.310 | eukaryotic translation initiation factor 3 subunit c |
Toxoplasma gondii | TGME49_294620 | eukaryotic initiation factor-3, subunit 8, putative |
Theileria parva | TP04_0739 | eukaryotic translation initiation factor 3 subunit 8, putative |
Trichomonas vaginalis | TVAG_184380 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.8270 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.8270 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.8270 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.8270 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T23D8.4 | Caenorhabditis elegans | sterile | wormbase |
YMR309C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0604800 | Plasmodium berghei | Essential | plasmo |
TGME49_294620 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.