Detailed view for EgrG_000479500

Basic information

TDR Targets ID: 575147
Echinococcus granulosus, mitochondrial carrier protein
Source Database / ID:  GeneDB

pI: 9.8438 | Length (AA): 445 | MW (Da): 49350 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
189 228 1c5d (H) 92 141 45.00 0.12 0.11 -0.0469124 3.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128577)

Species Accession Gene Product
Brugia malayi Bm1_15720   Mitochondrial carrier protein
Candida albicans CaO19.11975   likely mitochondrial carrier family protein similar to S. cerevisiae RIM2 (YBR192W) required for respiration
Candida albicans CaO19.4499   likely mitochondrial carrier family protein similar to S. cerevisiae RIM2 (YBR192W) required for respiration
Caenorhabditis elegans CELE_T09F3.2   Protein T09F3.2
Dictyostelium discoideum DDB_G0271922   mitochondrial substrate carrier family protein
Dictyostelium discoideum DDB_G0277891   mitochondrial substrate carrier family protein
Drosophila melanogaster Dmel_CG18317   Rim2 ortholog (S. cerevisiae)
Echinococcus granulosus EgrG_000479500   mitochondrial carrier protein
Echinococcus multilocularis EmuJ_000479500   mitochondrial carrier protein
Homo sapiens 84275   solute carrier family 25 (pyrimidine nucleotide carrier), member 33
Homo sapiens ENSG00000114120   solute carrier family 25 (pyrimidine nucleotide carrier), member 36
Leishmania braziliensis LbrM.15.0120   mitochondrial carrier protein, putative
Leishmania donovani LdBPK_150120.1   mitochondrial carrier protein, putative
Leishmania infantum LinJ.15.0120   mitochondrial carrier protein, putative
Leishmania major LmjF.15.0120   mitochondrial carrier protein, putative
Leishmania mexicana LmxM.15.0120   mitochondrial carrier protein, putative
Loa Loa (eye worm) LOAG_08295   carrier protein
Mus musculus ENSMUSG00000032449   solute carrier family 25, member 36
Mus musculus ENSMUSG00000028982   solute carrier family 25, member 33
Onchocerca volvulus OVOC11018   Carrier protein homolog
Saccharomyces cerevisiae YBR192W   Rim2p
Schistosoma japonicum Sjp_0200430   Solute carrier family 25 member 36, putative
Schistosoma japonicum Sjp_0002190   IPR001993,Mitochondrial substrate carrier,domain-containing
Schistosoma mansoni Smp_061250   mitochondrial carrier protein
Schmidtea mediterranea mk4.000418.04   Mitochondrial carrier protein, putative
Trypanosoma brucei gambiense Tbg972.5.2110   mitochondrial carrier protein, putative
Trypanosoma brucei Tb927.5.1550   mitochondrial carrier protein
Trypanosoma congolense TcIL3000_5_1470   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.510819.100   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.506739.80   mitochondrial carrier protein, putative

Essentiality

EgrG_000479500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1550 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.1550 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.1550 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.1550 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YBR192W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000479500 (Echinococcus granulosus), mitochondrial carrier protein
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