Detailed view for EgrG_000347200

Basic information

TDR Targets ID: 575565
Echinococcus granulosus, coiled coil domain containing protein 47
Source Database / ID:  GeneDB

pI: 6.1126 | Length (AA): 488 | MW (Da): 56480 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07946   Protein of unknown function (DUF1682)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
398 488 5l0w (A) 31 125 15.00 0 0.05 0.422875 -1.8
399 474 3s9g (A) 272 350 16.00 0.66 0 0.539838 -2.41
407 474 5nf8 (A) 89 155 34.00 0.84 0.03 0.495944 -0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128710)

Species Accession Gene Product
Arabidopsis thaliana AT5G49945   hypothetical protein
Arabidopsis thaliana AT4G24330   hypothetical protein
Babesia bovis BBOV_III007610   membrane protein, putative
Brugia malayi Bm1_44515   adipocyte-specific protein 4
Brugia malayi Bm1_55015   CG17593-PA
Candida albicans CaO19.9797   similar to S. cerevisiae YNR021W
Candida albicans CaO19.2257   similar to S. cerevisiae YNR021W
Caenorhabditis elegans CELE_ZK1058.4   Protein CCDC-47
Cryptosporidium hominis Chro.70258   hypothetical protein
Cryptosporidium parvum cgd7_2260   uncharacterized conserved protein, signal peptide
Dictyostelium discoideum DDB_G0280235   DUF1682 family protein
Drosophila melanogaster Dmel_CG17593   CG17593 gene product from transcript CG17593-RB
Echinococcus granulosus EgrG_000347200   coiled coil domain containing protein 47
Entamoeba histolytica EHI_057830   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000347200   coiled coil domain containing protein 47
Homo sapiens ENSG00000108588   coiled-coil domain containing 47
Loa Loa (eye worm) LOAG_02022   hypothetical protein
Mus musculus 67163   coiled-coil domain containing 47
Neospora caninum NCLIV_050030   hypothetical protein
Oryza sativa 4338884   Os05g0432400
Plasmodium berghei PBANKA_0806400   conserved protein, unknown function
Plasmodium falciparum PF3D7_0318900   conserved protein, unknown function
Plasmodium knowlesi PKNH_0822600   conserved protein, unknown function
Plasmodium vivax PVX_095290   hypothetical protein, conserved
Plasmodium yoelii PY00755   hypothetical protein
Saccharomyces cerevisiae YNR021W   hypothetical protein
Schistosoma japonicum Sjp_0014230   Coiled-coil domain-containing protein 47 precursor, putative
Schistosoma mansoni Smp_140080   adipocyte-specific protein 4-related
Schmidtea mediterranea mk4.001183.06  
Schmidtea mediterranea mk4.001183.07  
Schmidtea mediterranea mk4.001183.08  
Toxoplasma gondii TGME49_235660   hypothetical protein
Theileria parva TP04_0668   hypothetical protein

Essentiality

EgrG_000347200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK1058.4 Caenorhabditis elegans slow growth wormbase
PBANKA_0806400 Plasmodium berghei Dispensable plasmo
TGME49_235660 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000347200 (Echinococcus granulosus), coiled coil domain containing protein 47
Title for this comment
Comment