Detailed view for EgrG_000435900

Basic information

TDR Targets ID: 576024
Echinococcus granulosus, leucine rich repeat and calponin y
Source Database / ID:  GeneDB

pI: 8.3428 | Length (AA): 826 | MW (Da): 93515 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 212 4r5c (A) 104 302 34.00 0.000000000026 1 0.634788 -0.38
18 258 4u08 (A) 161 399 28.00 0 1 0.636268 -0.05
41 271 4r5d (A) 83 310 30.00 0.00000000026 1 0.524161 0.25
42 221 4u09 (A) 133 313 31.00 0 0.99 0.674418 -0.58
52 247 5kh1 (A) 112 276 35.00 0.00000067 0.9 0.380788 0.86
70 268 5xnq (A) 80 361 30.00 0.000004 1 0.46442 0.76
110 214 5yxm (A) 44 152 37.00 0.017 1 0.592619 -0.76
111 241 2o6r (A) 51 181 28.00 0.016 0.93 0.423096 -0.12
121 191 3rg1 (I) 138 211 45.00 0.34 0.99 0.508456 0.16
638 755 1p2x (A) 38 149 27.00 0.064 0.97 0.458457 -0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136351)

Species Accession Gene Product
Arabidopsis thaliana AT2G19330   ras group-related protein LRR 6
Arabidopsis thaliana AT4G29880   plant intracellular ras group-related LRR 7
Dictyostelium discoideum DDB_G0284461   C2 domain-containing protein
Dictyostelium discoideum DDB_G0279463   leucine-rich repeat-containing protein
Echinococcus granulosus EgrG_000435900   leucine rich repeat and calponin y
Echinococcus multilocularis EmuJ_000435900   leucine rich repeat and calponin y
Oryza sativa 4336911   Os04g0605300
Oryza sativa 4336157   Os04g0476700

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000435900 (Echinococcus granulosus), leucine rich repeat and calponin y
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