Detailed view for EgrG_000802000

Basic information

TDR Targets ID: 577733
Echinococcus granulosus, Splicing factor arginine:serine rich 2
Source Database / ID:  GeneDB

pI: 10.3917 | Length (AA): 123 | MW (Da): 14105 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 101 2lea (A) 1 101 62.00 0 1 1.60694 -0.77
2 103 2dnm (A) 2 103 56.00 0 1 1.58107 -1.03
16 87 2cqc (A) 120 191 46.00 0.000000000033 1 1.29307 -1.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127418)

Species Accession Gene Product
Arabidopsis thaliana AT5G64200   SC35-like splicing factor
Arabidopsis thaliana AT3G13570   SC35-like splicing factor 30A
Arabidopsis thaliana AT1G55310   SC35-like splicing factor 33
Arabidopsis thaliana AT3G55460   SC35-like splicing factor 30
Babesia bovis BBOV_II001870   RNA recognition motif containing protein
Babesia bovis BBOV_IV008500   Ser/Arg-rich splicing factor, putative
Brugia malayi Bm1_29600   RNA recognition motif domain containing protein
Caenorhabditis elegans CELE_EEED8.7   Protein RSP-4, isoform B
Cryptosporidium hominis Chro.70117   dentin phosphoryn
Cryptosporidium hominis Chro.60316   splicing factor
Cryptosporidium parvum cgd7_940   splicing factor RRM domain containing protein; T22E16.120 SC35-like splicing factor
Cryptosporidium parvum cgd6_2740   RRM domain containing protein; T22E16.120 Sc35-like splicing factor
Drosophila melanogaster Dmel_CG5442   CG5442 gene product from transcript CG5442-RC
Echinococcus granulosus EgrG_000710900   FUS interacting serine arginine rich protein 1
Echinococcus granulosus EgrG_000802000   Splicing factor arginine:serine rich 2
Entamoeba histolytica EHI_048210   splicing factor, arginine/serine-rich, putative
Echinococcus multilocularis EmuJ_000710900   FUS interacting serine arginine rich protein 1
Echinococcus multilocularis EmuJ_000461600   FUS interacting serine arginine rich protein 1
Echinococcus multilocularis EmuJ_000802000   Splicing factor, arginine:serine rich 2
Homo sapiens ENSG00000263465   serine/arginine-rich splicing factor 8
Homo sapiens ENSG00000161547   serine/arginine-rich splicing factor 2
Homo sapiens ENSG00000188529   serine/arginine-rich splicing factor 10
Loa Loa (eye worm) LOAG_00933   hypothetical protein
Mus musculus ENSMUSG00000034120   serine/arginine-rich splicing factor 2
Mus musculus ENSMUSG00000028676   serine/arginine-rich splicing factor 10
Neospora caninum NCLIV_036130   CBR-RSP-4 protein, related
Oryza sativa 4345884   Os08g0486200
Oryza sativa 4344009   Os07g0633200
Oryza sativa 4352590   Os12g0572400
Oryza sativa 4343955   Os07g0623300
Oryza sativa 4328900   Os02g0252100
Plasmodium berghei PBANKA_0921600   RNA-binding protein, putative
Plasmodium berghei PBANKA_1103000   serine/arginine-rich splicing factor 12, putative
Plasmodium falciparum PF3D7_1126800   RNA-binding protein, putative
Plasmodium falciparum PF3D7_0503300   serine/arginine-rich splicing factor 12
Plasmodium knowlesi PKNH_0924800   RNA-binding protein, putative
Plasmodium knowlesi PKNH_1030300   serine/arginine-rich splicing factor 12, putative
Plasmodium vivax PVX_097740   serine/arginine-rich splicing factor 12, putative
Plasmodium vivax PVX_091955   RNA-binding protein, putative
Plasmodium yoelii PY06769   hypothetical protein
Plasmodium yoelii PY04699   PR264
Plasmodium yoelii PY02124   dentin phosphoryn
Schistosoma japonicum Sjp_0003120   similar to 35 kDa SR repressor protein, putative
Schistosoma japonicum Sjp_0200880   Splicing factor, arginine/serine-rich 2, putative
Schistosoma mansoni Smp_032320.2   serine/arginine rich splicing factor
Schistosoma mansoni Smp_113620.3   serine/arginine rich splicing factor
Schistosoma mansoni Smp_113620.1   serine/arginine rich splicing factor
Schistosoma mansoni Smp_032320.6   serine/arginine rich splicing factor
Schistosoma mansoni Smp_113620.4   serine/arginine rich splicing factor
Schistosoma mansoni Smp_032320.1   serine/arginine rich splicing factor
Schmidtea mediterranea mk4.001733.03  
Toxoplasma gondii TGME49_272440   RNA recognition motif-containing protein
Toxoplasma gondii TGME49_270640   RNA recognition motif-containing protein
Theileria parva TP04_0393   hypothetical protein, conserved

Essentiality

EgrG_000802000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_EEED8.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_EEED8.7 Caenorhabditis elegans slow growth wormbase
PBANKA_0921600 Plasmodium berghei Dispensable plasmo
PBANKA_1103000 Plasmodium berghei Essential plasmo
TGME49_272440 Toxoplasma gondii Probably non-essential sidik
TGME49_270640 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000802000 (Echinococcus granulosus), Splicing factor arginine:serine rich 2
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