pI: 7.844 |
Length (AA): 1322 |
MW (Da): 149641 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 114 | 2rs6 (A) | 0 | 95 | 47.00 | 0 | 1 | 0.501077 | -0.37 |
7 | 86 | 3vyy (A) | 4 | 81 | 50.00 | 0 | 1 | 0.727514 | -1.23 |
140 | 1170 | 5aor (B) | 138 | 1148 | 48.00 | 0 | 1 | 1.32148 | -0.53 |
333 | 566 | 3llm (A) | 329 | 563 | 57.00 | 0 | 1 | 1.017 | -1.76 |
1188 | 1322 | 4oua (A) | 178 | 312 | 11.00 | 0 | 0.01 | 0.221718 | -0.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126805)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G58060 | RNA helicase family protein |
Arabidopsis thaliana | AT2G01130 | DEA(D/H)-box RNA helicase family protein |
Arabidopsis thaliana | AT5G04895 | DEA(D/H)-box RNA helicase family protein |
Arabidopsis thaliana | AT1G58050 | RNA helicase family protein |
Arabidopsis thaliana | AT1G48650 | DEA(D/H)-box RNA helicase family protein |
Arabidopsis thaliana | AT2G35920 | RNA helicase family protein |
Brugia malayi | Bm1_34210 | Probable ATP-dependent RNA helicase A |
Candida albicans | CaO19.6818 | RNA helicase |
Candida albicans | CaO19.14110 | RNA helicase |
Caenorhabditis elegans | CELE_T07D4.3 | Protein RHA-1 |
Cryptosporidium hominis | Chro.70141 | hypothetical protein |
Cryptosporidium parvum | cgd7_1160 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0267516 | DEAD/DEAH box helicase |
Dictyostelium discoideum | DDB_G0275313 | ATP-dependent RNA helicase |
Drosophila melanogaster | Dmel_CG11680 | maleless |
Drosophila melanogaster | Dmel_CG9323 | CG9323 gene product from transcript CG9323-RB |
Drosophila melanogaster | Dmel_CG1582 | CG1582 gene product from transcript CG1582-RB |
Echinococcus granulosus | EgrG_000228800 | ATP dependent RNA helicase DHX36 |
Echinococcus granulosus | EgrG_000242500 | Dosage compensation regulator |
Entamoeba histolytica | EHI_053600 | helicase, putative |
Echinococcus multilocularis | EmuJ_000242500 | Dosage compensation regulator |
Echinococcus multilocularis | EmuJ_000228800 | ATP dependent RNA helicase DHX36 |
Homo sapiens | ENSG00000067248 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 |
Homo sapiens | ENSG00000174953 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 |
Homo sapiens | ENSG00000135829 | DEAH (Asp-Glu-Ala-His) box helicase 9 |
Homo sapiens | ENSG00000163214 | DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 |
Leishmania braziliensis | LbrM.09.0090 | RNA helicase, putative |
Leishmania donovani | LdBPK_090090.1 | RNA helicase, putative |
Leishmania infantum | LinJ.09.0090 | RNA helicase, putative |
Leishmania major | LmjF.09.0070 | RNA helicase, putative |
Leishmania mexicana | LmxM.09.0070 | RNA helicase, putative |
Loa Loa (eye worm) | LOAG_04223 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04222 | hypothetical protein |
Mus musculus | ENSMUSG00000027770 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 |
Mus musculus | ENSMUSG00000035051 | DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 |
Mus musculus | ENSMUSG00000042699 | DEAH (Asp-Glu-Ala-His) box polypeptide 9 |
Mus musculus | ENSMUSG00000042426 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 |
Neospora caninum | NCLIV_028950 | hypothetical protein |
Oryza sativa | 9267691 | Os04g0432300 |
Oryza sativa | 4326075 | Os01g0118100 |
Oryza sativa | 4334111 | Os03g0748800 |
Oryza sativa | 4335879 | Os04g0432200 |
Saccharomyces cerevisiae | YLR419W | putative helicase |
Schistosoma japonicum | Sjp_0075780 | Probable ATP-dependent RNA helicase DHX36, putative |
Schistosoma japonicum | Sjp_0016940 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma japonicum | Sjp_0075770 | Probable ATP-dependent RNA helicase DHX36, putative |
Schistosoma japonicum | Sjp_0310260 | Probable ATP-dependent RNA helicase DHX36, putative |
Schistosoma japonicum | Sjp_0075790 | Probable ATP-dependent RNA helicase DHX36, putative |
Schistosoma mansoni | Smp_152840 | ATP-dependent RNA Helicase |
Schistosoma mansoni | Smp_035030 | ATP-dependent RNA Helicase |
Schmidtea mediterranea | mk4.000400.04 | Probable ATP-dependent RNA helicase A |
Schmidtea mediterranea | mk4.000400.05 | Probable ATP-dependent RNA helicase A |
Schmidtea mediterranea | mk4.000400.11 | Probable ATP-dependent RNA helicase A |
Trypanosoma brucei gambiense | Tbg972.11.13550 | RNA helicase, putative |
Trypanosoma brucei | Tb927.11.12110 | RNA helicase, putative |
Trypanosoma congolense | TcIL3000.11.12730 | RNA helicase, putative |
Trypanosoma cruzi | TcCLB.504005.3 | RNA helicase, putative |
Trypanosoma cruzi | TcCLB.511481.60 | RNA helicase, putative |
Toxoplasma gondii | TGME49_284050 | DEAD/DEAH box helicase domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.3930 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3930 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3930 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.3930 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T07D4.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T07D4.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_284050 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.