pI: 7.8191 |
Length (AA): 127 |
MW (Da): 13697 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 127 | 2ozb (A) | 5 | 128 | 68.00 | 0 | 1 | 1.96158 | -2.15 |
6 | 127 | 5ewr (A) | 24 | 145 | 57.00 | 0 | 1 | 1.84383 | -2.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127322)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G22380 | ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein |
Arabidopsis thaliana | AT4G12600 | ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein |
Babesia bovis | BBOV_III009740 | ribosomal protein L7A, putative |
Brugia malayi | Bm1_42550 | NHP2/L7aE family protein YEL026W homolog |
Candida albicans | CaO19.5885 | similar to highly conserved 15.5 kd RNA binding protein/S. cerevisiae SNU13 (YEL026W) that binds to both spliceosomal U4 snRNA a |
Candida albicans | CaO19.13306 | similar to highly conserved 15.5 kd RNA binding protein/S. cerevisiae SNU13 (YEL026W) that binds to both spliceosomal U4 snRNA a |
Caenorhabditis elegans | CELE_M28.5 | Protein M28.5 |
Cryptosporidium hominis | Chro.60440 | ribosomal protein L7A |
Cryptosporidium parvum | cgd6_3850 | HOI-POLLOI protein; U4/U6.U5 snRNP component; Snu13p; pelota RNA binding domain containing protein |
Dictyostelium discoideum | DDB_G0282243 | U4/U6 small nuclear ribonucleoprotein |
Drosophila melanogaster | Dmel_CG3949 | hoi-polloi |
Echinococcus granulosus | EgrG_001075100 | NHP2 non histone chromosome protein 2 1 |
Entamoeba histolytica | EHI_053440 | 13 kDa ribonucleoprotein-associated protein, putative |
Entamoeba histolytica | EHI_104600 | 13 kDa ribonucleoprotein-associated protein, putative |
Echinococcus multilocularis | EmuJ_001075100 | NHP2 non histone chromosome protein 2 1 |
Giardia lamblia | GL50803_2825 | Ribosomal protein L7Ae |
Giardia lamblia | GL50803_11287 | Ribosomal protein L7Ae |
Homo sapiens | ENSG00000100138 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) |
Leishmania braziliensis | LbrM.15.1470 | ribosomal protein S6, putative,NPH2/RS6-like protein |
Leishmania donovani | LdBPK_151530.1 | ribosomal protein S6, putative |
Leishmania infantum | LinJ.15.1530 | ribosomal protein S6, putative,NPH2/RS6-like protein |
Leishmania major | LmjF.15.1470 | ribosomal protein S6, putative,NPH2/RS6-like protein |
Leishmania mexicana | LmxM.15.1470 | ribosomal protein S6, putative,NPH2/RS6-like protein |
Loa Loa (eye worm) | LOAG_03139 | hypothetical protein |
Mus musculus | 100862468 | NHP2-like protein 1-like |
Mus musculus | 102641864 | NHP2-like protein 1-like |
Mus musculus | ENSMUSG00000063480 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) |
Neospora caninum | NCLIV_050630 | H/ACA ribonucleoprotein complex subunit 2-like protein, related |
Oryza sativa | 4332209 | Os03g0241200 |
Oryza sativa | 4348007 | Os10g0124000 |
Plasmodium berghei | PBANKA_0924400 | splicing factor, putative |
Plasmodium falciparum | PF3D7_1123900 | splicing factor, putative |
Plasmodium knowlesi | PKNH_0921700 | high mobility group-like protein NHP2, putative |
Plasmodium vivax | PVX_091810 | ribosomal protein L7A, putative |
Plasmodium yoelii | PY03136 | nhp2-like protein 1-related |
Saccharomyces cerevisiae | YEL026W | RNA binding protein SNU13 |
Schistosoma japonicum | Sjp_0041070 | ko:K02936 large subunit ribosomal protein L7Ae, putative |
Schistosoma mansoni | Smp_104660 | ribosomal protein l7ae |
Schmidtea mediterranea | mk4.001604.02 | Ribosomal protein l7ae, putative |
Trypanosoma brucei gambiense | Tbg972.9.2720 | ribosomal protein S6, putative,NHP2/RS6-like protein |
Trypanosoma brucei | Tb927.9.5150 | ribosomal protein S6, putative |
Trypanosoma congolense | TcIL3000_9_1680 | ribosomal protein S6, putative |
Trypanosoma cruzi | TcCLB.509943.30 | ribosomal protein S6, putative |
Trypanosoma cruzi | TcCLB.508277.120 | ribosomal protein S6, putative |
Toxoplasma gondii | TGME49_236580 | Prp31-15.5k-U4 Snrna Complex family protein |
Theileria parva | TP04_0892 | NHP2/L7Ae family protein, putative |
Trichomonas vaginalis | TVAG_282030 | ribosomal protein l7ae, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.3670 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3670 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3670 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.3670 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_M28.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_M28.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_M28.5 | Caenorhabditis elegans | larval lethal | wormbase |
YEL026W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_236580 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.