Detailed view for EgrG_000068700

Basic information

TDR Targets ID: 578500
Echinococcus granulosus, eukaryotic translation initiation factor 3
Source Database / ID:  GeneDB

pI: 5.2032 | Length (AA): 273 | MW (Da): 30742 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01398   JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PF13012   Maintenance of mitochondrial structure and function

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0005515   protein binding  
GO:0003743   translation initiation factor activity  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 82 3ax1 (A) 240 363 37.00 0.68 0.33 0.435903 0.84
3 175 2o95 (A) 5 181 27.00 0.000000011 1 1.0015 -0.65
6 273 4d10 (F) 40 307 23.00 0 0.94 1.18248 0.66
6 172 5w83 (A) 7 177 31.00 0 1 1.02192 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128941)

Species Accession Gene Product
Arabidopsis thaliana AT2G39990   translation initiation factor 3 subunit F
Babesia bovis BBOV_II001460   mov34/MPN/PAD-1 family protein
Brugia malayi Bm1_43720   hypothetical protein
Brugia malayi Bm1_43725   Mov34/MPN/PAD-1 family protein
Candida albicans CaO19.11759   similar to human translation initiation factor eIF3-epsilon-p47 subunit and to S. pombe SPBC4C3.07
Candida albicans CaO19.4283   similar to human translation initiation factor eIF3-epsilon-p47 subunit and to S. pombe SPBC4C3.07
Caenorhabditis elegans CELE_D2013.7   Protein EIF-3.F
Cryptosporidium hominis Chro.70132   hypothetical protein
Cryptosporidium parvum cgd7_1080   eIF3-p47 with JAB/PAD domain
Dictyostelium discoideum DDB_G0293254   Mov34/MPN/PAD-1 family protein
Drosophila melanogaster Dmel_CG9769   CG9769 gene product from transcript CG9769-RA
Drosophila melanogaster Dmel_CG8335   CG8335 gene product from transcript CG8335-RA
Echinococcus granulosus EgrG_000068700   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_000068700   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000175390   eukaryotic translation initiation factor 3, subunit F
Loa Loa (eye worm) LOAG_08925   Mov34/MPN/PAD-1 family protein
Loa Loa (eye worm) LOAG_08926   eukaryotic Initiation Factor family member
Mus musculus 66085   eukaryotic translation initiation factor 3, subunit F
Neospora caninum NCLIV_045240   eukaryotic translation initiation factor 3 subunit 5, putative
Oryza sativa 4337552   Os05g0104800
Plasmodium berghei PBANKA_0819300   eukaryotic translation initiation factor 3 subunit F, putative
Plasmodium falciparum PF3D7_0918300   eukaryotic translation initiation factor 3 subunit F, putative
Plasmodium knowlesi PKNH_0716300   eukaryotic translation initiation factor 3 subunit F, putative
Plasmodium vivax PVX_099335   eukaryotic translation initiation factor 3 subunit 5, putative
Plasmodium yoelii PY02659   no apparent S. cerevisiae ortholog, putative
Schistosoma japonicum Sjp_0108940   Eukaryotic translation initiation factor 3 subunit F, putative
Schistosoma mansoni Smp_078320   eukaryotic translation initiation factor 3 subunit 5 (M67 family)
Schmidtea mediterranea mk4.000048.03   Eukaryotic translation initiation factor 3 subunit F
Toxoplasma gondii TGME49_228190   eukaryotic initiation factor-3, subunit 5, putative
Theileria parva TP04_0444   hypothetical protein, conserved
Trichomonas vaginalis TVAG_486970   conserved hypothetical protein

Essentiality

EgrG_000068700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_D2013.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_D2013.7 Caenorhabditis elegans larval arrest wormbase
CELE_D2013.7 Caenorhabditis elegans slow growth wormbase
TGME49_228190 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000068700 (Echinococcus granulosus), eukaryotic translation initiation factor 3
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