Detailed view for EgrG_000662200

Basic information

TDR Targets ID: 579716
Echinococcus granulosus, oxalate:formate antiporter
Source Database / ID:  GeneDB

pI: 5.3796 | Length (AA): 279 | MW (Da): 31151 | Paralog Number: 12

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
56 252 4j05 (A) 311 518 12.00 0.0000027 0.11 0.788893 -0.42
122 229 4khz (G) 47 168 31.00 0.82 0.14 0.274197 3.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127853)

Species Accession Gene Product
Brugia malayi Bm1_12830   Major Facilitator Superfamily protein
Caenorhabditis elegans CELE_F10G7.5   Protein F10G7.5, isoform A
Caenorhabditis elegans CELE_Y59A8B.21   Protein Y59A8B.21
Cryptosporidium hominis Chro.70281   hypothetical protein
Cryptosporidium parvum cgd7_2450   possible membrane associated transporter
Dictyostelium discoideum DDB_G0273195   oxalate/formate antiporter
Dictyostelium discoideum DDB_G0273735   oxalate/formate antiporter
Dictyostelium discoideum DDB_G0274807   hypothetical protein
Escherichia coli b3547   pyruvate-inducible inner membrane protein, putative transporter
Echinococcus granulosus EgrG_000662500   oxalate:formate antiporter
Echinococcus granulosus EgrG_000017400   oxalate:formate antiporter
Echinococcus granulosus EgrG_000586900   oxalate:formate antiporter
Echinococcus granulosus EgrG_000641700   Major Facilitator Superfamily protein
Echinococcus granulosus EgrG_000343700   oxalate:formate antiporter
Echinococcus granulosus EgrG_000662200   oxalate:formate antiporter
Echinococcus granulosus EgrG_000843700   oxalate:formate antiporter
Echinococcus granulosus EgrG_000633400   oxalate:formate antiporter
Echinococcus granulosus EgrG_000418800   oxalate:formate antiporter
Echinococcus granulosus EgrG_000586800   oxalate:formate antiporter
Echinococcus granulosus EgrG_000606100   oxalate:formate antiporter
Echinococcus granulosus EgrG_000661800   oxalate:formate antiporter
Echinococcus granulosus EgrG_000586700   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000586900   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000606100   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000418800   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000633400   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000662200   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000017400   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000843700   hypothetical protein
Echinococcus multilocularis EmuJ_000641700   Major Facilitator Superfamily protein
Echinococcus multilocularis EmuJ_000586700   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000343700   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000586800   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000661800   oxalate:formate antiporter
Echinococcus multilocularis EmuJ_000662500   oxalate:formate antiporter
Homo sapiens ENSG00000174327   solute carrier family 16, member 13
Loa Loa (eye worm) LOAG_01885   major facilitator superfamily transporter
Mus musculus ENSMUSG00000044367   solute carrier family 16 (monocarboxylic acid transporters), member 13
Neospora caninum NCLIV_006330   hypothetical protein
Onchocerca volvulus OVOC6475  
Plasmodium berghei PBANKA_0307200   monocarboxylate transporter, putative
Plasmodium falciparum PF3D7_0210300   monocarboxylate transporter, putative
Plasmodium knowlesi PKNH_0410900   monocarboxylate transporter, putative
Plasmodium vivax PVX_003965   monocarboxylate transporter, putative
Plasmodium yoelii PY00444   hypothetical protein
Schistosoma japonicum Sjp_0301980   ko:K08177 MFS transporter, OFA family, oxalate/formate antiporter, putative
Schistosoma japonicum Sjp_0095730   IPR011701,Major facilitator superfamily MFS_1,domain-containing
Schistosoma japonicum Sjp_0061110   Oxalate:formate antiporter, putative
Schistosoma japonicum Sjp_0098510   Conserved hypothetical protein
Schistosoma japonicum Sjp_0061220   expressed protein
Schistosoma japonicum Sjp_0057260   ko:K08177 MFS transporter, OFA family, oxalate/formate antiporter, putative
Schistosoma japonicum Sjp_0061120   ko:K08177 MFS transporter, OFA family, oxalate/formate antiporter, putative
Schistosoma mansoni Smp_134980   oxalate:formate antiporter
Schistosoma mansoni Smp_145560   oxalate:formate antiporter
Schistosoma mansoni Smp_135020   oxalate:formate antiporter
Schistosoma mansoni Smp_036470   oxalate:formate antiporter
Schistosoma mansoni Smp_135010   oxalate:formate antiporter
Schmidtea mediterranea mk4.002881.01  
Schmidtea mediterranea mk4.019801.01  
Schmidtea mediterranea mk4.059715.00  
Schmidtea mediterranea mk4.002131.03  
Schmidtea mediterranea mk4.002692.02  
Schmidtea mediterranea mk4.009255.05  
Schmidtea mediterranea mk4.033185.00  
Schmidtea mediterranea mk4.023907.00  
Schmidtea mediterranea mk4.013336.00  
Schmidtea mediterranea mk4.006639.00  
Schmidtea mediterranea mk4.002091.02  
Schmidtea mediterranea mk4.000176.13  
Schmidtea mediterranea mk4.016522.00  
Schmidtea mediterranea mk4.002881.02  
Toxoplasma gondii TGME49_297245   transporter, major facilitator family protein
Toxoplasma gondii TGME49_233540   transporter, major facilitator family protein
Theileria parva TP03_0374   membrane transporter, putative

Essentiality

EgrG_000662200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3547 Escherichia coli non-essential goodall
CELE_F10G7.5 Caenorhabditis elegans slow growth wormbase
TGME49_297245 Toxoplasma gondii Probably essential sidik
TGME49_233540 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000662200 (Echinococcus granulosus), oxalate:formate antiporter
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