Detailed view for EgrG_000597800

Basic information

TDR Targets ID: 580227
Echinococcus granulosus, NADH dehydrogenase ubiquinone iron sulfur
Source Database / ID:  GeneDB

pI: 7.6637 | Length (AA): 166 | MW (Da): 19079 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04800   ETC complex I subunit conserved region

Gene Ontology

Mouse over links to read term descriptions.
GO:0016651   oxidoreductase activity, acting on NADH or NADPH  
GO:0022900   electron transport chain  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
61 160 2lju (A) 3 103 32.00 0 0.94 0.89181 0.93
66 144 2jya (A) 1 80 34.00 0 0.57 0.861304 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129903)

Species Accession Gene Product
Arabidopsis thaliana AT5G67590   NADH dehydrogenase [ubiquinone] iron-sulfur protein 4
Brugia malayi Bm1_55425   ETC complex I subunit conserved region family protein
Brugia malayi Bm1_41915   NADH-ubiquinone oxidoreductase 18 kDa subunit, mitochondrial precursor
Candida albicans CaO19.3290   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-21kd subunit and mammalian CI-1
Candida albicans CaO19.10800   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-21kd subunit and mammalian CI-1
Caenorhabditis elegans CELE_ZK973.10   Protein LPD-5
Dictyostelium discoideum DDB_G0295657   ETC complex I subunit conserved family protein
Drosophila melanogaster Dmel_CG12203   CG12203 gene product from transcript CG12203-RA
Echinococcus granulosus EgrG_000597800   NADH dehydrogenase ubiquinone iron sulfur
Echinococcus multilocularis EmuJ_000597800   NADH dehydrogenase (ubiquinone) iron sulfur
Homo sapiens ENSG00000164258   NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Loa Loa (eye worm) LOAG_03576   NADH-ubiquinone oxidoreductase 18 kDa subunit
Mus musculus ENSMUSG00000021764   NADH dehydrogenase (ubiquinone) Fe-S protein 4
Oryza sativa 4343746   Os07g0585800
Schistosoma japonicum Sjp_0200200   ko:K03937 NADH dehydrogenase (ubiquinone) Fe-S protein 4, putative
Schistosoma japonicum Sjp_0311830   NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor, putative
Schistosoma mansoni Smp_018020   hypothetical protein
Schmidtea mediterranea mk4.000237.07   NADH dehydrogenase
Wolbachia endosymbiont of Brugia malayi Wbm0545   NADH:ubiquinone oxidoreductase 18 kDa subunit

Essentiality

EgrG_000597800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK973.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK973.10 Caenorhabditis elegans larval arrest wormbase
CELE_ZK973.10 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000597800 (Echinococcus granulosus), NADH dehydrogenase ubiquinone iron sulfur
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