pI: 7.4467 |
Length (AA): 493 |
MW (Da): 51592 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 44 | 5yjj (A) | 499 | 542 | 16.00 | 0.0027 | 0.03 | 0.29785 | -0.8 |
51 | 218 | 2anr (A) | 4 | 177 | 54.00 | 0 | 1 | 0.981371 | -1.21 |
55 | 131 | 1ec6 (A) | 8 | 85 | 39.00 | 0.00000013 | 1 | 0.726187 | -0.97 |
142 | 216 | 5wwx (A) | 324 | 393 | 23.00 | 0 | 0.94 | 0.54773 | -1.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130250)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G04430 | TOMV RNA binding protein |
Brugia malayi | Bm1_19775 | KH domain containing protein |
Caenorhabditis elegans | CELE_Y59A8B.10 | Protein Y59A8B.10, isoform C |
Drosophila melanogaster | Dmel_CG42670 | pasilla |
Echinococcus granulosus | EgrG_000842600 | RNA binding protein Nova 1 |
Echinococcus granulosus | EgrG_000486900 | RNA binding protein Nova 1 |
Echinococcus granulosus | EgrG_000378900 | RNA binding protein Nova |
Echinococcus multilocularis | EmuJ_000842600 | RNA binding protein Nova 1 |
Echinococcus multilocularis | EmuJ_000486900 | RNA binding protein Nova 1 |
Echinococcus multilocularis | EmuJ_000378900 | RNA binding protein Nova |
Homo sapiens | 4858 | neuro-oncological ventral antigen 2 |
Homo sapiens | ENSG00000139910 | neuro-oncological ventral antigen 1 |
Loa Loa (eye worm) | LOAG_06799 | hypothetical protein |
Mus musculus | ENSMUSG00000021047 | neuro-oncological ventral antigen 1 |
Mus musculus | ENSMUSG00000030411 | neuro-oncological ventral antigen 2 |
Neospora caninum | NCLIV_062620 | HnRNP-E2 protein, related |
Oryza sativa | 4331186 | Os02g0822300 |
Onchocerca volvulus | OVOC6120 |
|
Plasmodium berghei | PBANKA_1027400 | RNA-binding protein Nova-1, putative |
Plasmodium falciparum | PF3D7_1415300 | RNA-binding protein Nova-1, putative |
Plasmodium knowlesi | PKNH_1342800 | RNA-binding protein Nova-1, putative |
Plasmodium vivax | PVX_085685 | RNA-binding protein Nova-1, putative |
Plasmodium yoelii | PY04454 | RNA-binding protein Nova-2 |
Schistosoma japonicum | Sjp_0024140 | RNA-binding protein Nova-1, putative |
Schistosoma mansoni | Smp_049010 | rna-binding protein related |
Schmidtea mediterranea | mk4.000282.08 | Rna-binding protein related |
Schmidtea mediterranea | mk4.000059.15 | Pasilla |
Schmidtea mediterranea | mk4.002333.03 | Pasilla |
Schmidtea mediterranea | mk4.000344.06 | Rna-binding protein related |
Toxoplasma gondii | TGME49_217880 | RNA-binding protein Nova-1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_217880 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.