Detailed view for EgrG_000237400

Basic information

TDR Targets ID: 581269
Echinococcus granulosus, rho guanine nucleotide exchange factor 16
Source Database / ID:  GeneDB

pI: 9.4015 | Length (AA): 847 | MW (Da): 96157 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00621   RhoGEF domain
PF14604   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
285 603 1txd (A) 768 1095 21.00 0 1 0.502623 0.03
285 639 3odo (A) 397 745 19.00 0 1 0.572126 -0.03
296 631 5jhh (A) 723 1068 23.00 0.000000000033 1 0.666394 -0.1
305 493 3gf9 (A) 1179 1365 30.00 0 1 0.645841 -0.93
314 662 1kz7 (A) 639 965 24.00 0.0000023 1 0.598742 0.13
360 622 5hzi (A) 1434 1685 29.00 0.0000000054 0.94 0.333208 1.41
503 567 4rd8 (A) 44 106 33.00 0.72 0.08 0.283441 0.91
745 804 4esr (A) 1054 1113 28.00 0 0.94 0.518838 -1.25
745 806 2k9g (A) 270 332 31.00 0 1 0.4992 -1.16
746 798 2dl5 (A) 15 68 30.00 0 0.72 0.384574 -0.2
754 793 1zuy (A) 12 52 45.00 0.099 0.97 0.623926 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133193)

Species Accession Gene Product
Brugia malayi Bm1_43785   Variant SH3 domain containing protein
Caenorhabditis elegans CELE_K07D4.7   Protein EPHX-1, isoform B
Echinococcus granulosus EgrG_000237400   rho guanine nucleotide exchange factor 16
Echinococcus multilocularis EmuJ_000076400   guanine nucleotide exchange factor
Echinococcus multilocularis EmuJ_000237400   rho guanine nucleotide exchange factor 16
Homo sapiens ENSG00000066248   neuronal guanine nucleotide exchange factor
Loa Loa (eye worm) LOAG_02988   hypothetical protein
Mus musculus ENSMUSG00000026259   neuronal guanine nucleotide exchange factor
Schistosoma japonicum Sjp_0065880   Rho guanine nucleotide exchange factor 16, putative
Schistosoma japonicum Sjp_0065890   ko:K07525 neuronal guanine nucleotide exchange factor, putative
Schistosoma mansoni Smp_012580   guanine-nucleotide-exchange-factor
Schmidtea mediterranea mk4.008313.01   Rho guanine nucleotide exchange factor 35
Schmidtea mediterranea mk4.006755.01   Putative guanine-nucleotide-exchange-factor
Schmidtea mediterranea mk4.021311.00   Rho guanine nucleotide exchange factor 35
Schmidtea mediterranea mk4.011879.01   Putative guanine-nucleotide-exchange-factor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000237400 (Echinococcus granulosus), rho guanine nucleotide exchange factor 16
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