Detailed view for EgrG_000133900

Basic information

TDR Targets ID: 581367
Echinococcus granulosus, dual specificity protein phosphatase 14
Source Database / ID:  GeneDB

pI: 10.103 | Length (AA): 200 | MW (Da): 22429 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00782   Dual specificity phosphatase, catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0008138   protein tyrosine/serine/threonine phosphatase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 173 2oud (A) 320 488 26.00 0 1 1.2734 -1.14
3 160 2wgp (A) 25 177 39.00 0.00000000004 1 1.3535 -1.2
3 167 2esb (A) 18 171 39.00 0 1 1.3374 -1.27
5 154 2hcm (A) 11 155 29.00 0 1 1.2254 -1.54
63 145 3emu (A) 363 448 29.00 0.0053 0.93 0.8363 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132659)

Species Accession Gene Product
Brugia malayi Bm1_47545   Dual specificity phosphatase, catalytic domain containing protein
Caenorhabditis elegans CELE_C04F12.8   Protein C04F12.8
Drosophila melanogaster Dmel_CG15528   CG15528 gene product from transcript CG15528-RB
Echinococcus granulosus EgrG_000420200   dual specificity protein phosphatase 14
Echinococcus granulosus EgrG_000133900   dual specificity protein phosphatase 14
Echinococcus multilocularis EmuJ_000133900   dual specificity protein phosphatase 14
Echinococcus multilocularis EmuJ_000420200   dual specificity protein phosphatase 14
Homo sapiens ENSG00000276023   dual specificity phosphatase 14
Loa Loa (eye worm) LOAG_05814   dual specificity phosphatase
Mus musculus ENSMUSG00000018648   dual specificity phosphatase 14
Onchocerca volvulus OVOC1396  
Saccharomyces cerevisiae YIL113W   Sdp1p
Schistosoma japonicum Sjp_0312100   expressed protein
Schistosoma japonicum Sjp_0104300   ko:K04459 dual specificity phosphatase, putative
Schistosoma mansoni Smp_038530   map kinase phosphatase
Schmidtea mediterranea mk4.003041.00   Putative map kinase phosphatase
Schmidtea mediterranea mk4.028595.01   Putative map kinase phosphatase
Schmidtea mediterranea mk4.011730.02   Putative map kinase phosphatase
Schmidtea mediterranea mk4.004840.01   Putative map kinase phosphatase
Schmidtea mediterranea mk4.010535.00   Putative map kinase phosphatase
Schmidtea mediterranea mk4.001685.06   Putative map kinase phosphatase
Schmidtea mediterranea mk4.006215.00   Putative map kinase phosphatase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000133900 (Echinococcus granulosus), dual specificity protein phosphatase 14
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