Detailed view for EgrG_000170300

Basic information

TDR Targets ID: 582799
Echinococcus granulosus, guanylate kinase
Source Database / ID:  GeneDB

pI: 6.2398 | Length (AA): 254 | MW (Da): 28856 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Purine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 117 3tau (A) 4 117 39.00 0.0017 0.87 0.940056 -0.26
5 254 4wsi (A) 480 672 39.00 0 1 1.06135 0.46
5 239 1ex7 (A) 2 185 50.00 0.0003 1 1.2425 -0.03
5 236 4f4j (B) 3 183 51.00 0 1 1.11149 0.25
5 88 1kgd (A) 735 818 36.00 0.0000000028 0.98 0.773809 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131999)

Species Accession Gene Product
Brugia malayi Bm1_20030   hypothetical protein
Drosophila melanogaster Dmel_CG14015   CG14015 gene product from transcript CG14015-RA
Echinococcus granulosus EgrG_000170300   guanylate kinase
Echinococcus multilocularis EmuJ_000170300   guanylate kinase
Homo sapiens ENSG00000172469   mannosidase, endo-alpha
Homo sapiens ENSG00000185090   mannosidase, endo-alpha-like
Loa Loa (eye worm) LOAG_11660   hypothetical protein
Mus musculus ENSMUSG00000042763   mannosidase, endo-alpha-like
Mus musculus ENSMUSG00000040520   mannosidase, endo-alpha
Onchocerca volvulus OVOC1477  
Schistosoma japonicum Sjp_0028300   ko:K01238 similar to mannosidase [EC:3.2.1.-], putative
Schistosoma japonicum Sjp_0028310   ko:K00942 guanylate kinase [EC2.7.4.8], putative
Schistosoma mansoni Smp_016880   mannosidase endo-alpha
Trichomonas vaginalis TVAG_150290   mannosidase, endo-alpha, putative
Trichomonas vaginalis TVAG_319490   mannosidase, endo-alpha, putative
Trichomonas vaginalis TVAG_137190   mannosidase, endo-alpha, putative
Trichomonas vaginalis TVAG_117050   mannosidase, endo-alpha, putative
Trichomonas vaginalis TVAG_040840   mannosidase, endo-alpha, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000170300 (Echinococcus granulosus), guanylate kinase
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