Detailed view for EgrG_001083200

Basic information

TDR Targets ID: 584184
Echinococcus granulosus, kelch protein 18
Source Database / ID:  GeneDB

pI: 6.0261 | Length (AA): 799 | MW (Da): 87197 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00651   BTB/POZ domain
PF01344   Kelch motif
PF07707   BTB And C-terminal Kelch

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 62 1buo (A) 62 123 19.00 0 0.32 0.345997 -0.79
1 63 1r29 (A) 65 127 21.00 0 0.43 0.426249 -1.27
2 62 5mw6 (B) 62 126 25.00 0.051 0.75 0.414545 -0.83
8 62 2vpk (A) 62 116 20.00 0 0.97 0.466236 -1.33
10 62 2if5 (A) 75 127 28.00 0 0.96 0.553733 -1.44
263 538 2dyh (A) 367 609 42.00 0 1 0.703632 -0.08
269 568 4ch9 (A) 302 565 35.00 0 1 0.661869 -0.09
691 778 5o02 (A) 316 403 17.00 0 0 0.270538 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134834)

Species Accession Gene Product
Brugia malayi Bm1_26330   Kelch motif family protein
Caenorhabditis elegans CELE_T27E9.4   Protein KEL-3, isoform B
Drosophila melanogaster Dmel_CG3571   CG3571 gene product from transcript CG3571-RC
Echinococcus granulosus EgrG_001083200   kelch protein 18
Echinococcus multilocularis EmuJ_001093900   BTB:POZ domain containing protein
Echinococcus multilocularis EmuJ_000408400   Kelch repeat type 1
Echinococcus multilocularis EmuJ_001083200   kelch protein 18
Homo sapiens ENSG00000114648   kelch-like family member 18
Loa Loa (eye worm) LOAG_01937   kelch domain-containing protein family protein
Mus musculus ENSMUSG00000054792   kelch-like 18
Schistosoma japonicum Sjp_0120570   Kelch-like protein 18, putative
Schistosoma japonicum Sjp_0133250   Kelch-like protein 18, putative
Schistosoma japonicum Sjp_0084110   ko:K03252 translation initiation factor eIF-3 subunit 8, putative
Schistosoma mansoni Smp_122340   hypothetical protein
Schmidtea mediterranea mk4.007040.00  
Schmidtea mediterranea mk4.001967.00  
Schmidtea mediterranea mk4.001967.01  

Essentiality

EgrG_001083200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T27E9.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001083200 (Echinococcus granulosus), kelch protein 18
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