pI: 9.6467 |
Length (AA): 158 |
MW (Da): 18512 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
31 | 122 | 3fbi (B) | 20 | 108 | 30.00 | 0 | 0.32 | 0.866879 | -0.08 |
35 | 128 | 5n9j (R) | 15 | 104 | 29.00 | 0 | 0.99 | 1.02154 | -0.83 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128731)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19910 | mediator of RNA polymerase II transcription subunit 31 |
Babesia bovis | BBOV_III002400 | SOH1 family protein |
Brugia malayi | Bm1_32655 | SOH1 family protein |
Candida albicans | CaO19.1429 | interacts with Rad5 DNA repair protein |
Candida albicans | CaO19.9005 | interacts with Rad5 DNA repair protein |
Caenorhabditis elegans | CELE_F32H2.2 | Protein MDT-31, isoform A |
Cryptosporidium hominis | Chro.30376 | similar to CGI-125 protein |
Cryptosporidium parvum | cgd3_3300 | SOH1 family protein |
Dictyostelium discoideum | DDB_G0285221 | hypothetical protein |
Drosophila melanogaster | Dmel_CG1057 | Mediator complex subunit 31 |
Echinococcus granulosus | EgrG_000235500 | Mediator of RNA polymerase II transcription |
Entamoeba histolytica | EHI_030160 | SOH1 protein, putative |
Echinococcus multilocularis | EmuJ_000235500 | Mediator of RNA polymerase II transcription |
Giardia lamblia | GL50803_20633 | SOH1 protein, putative |
Homo sapiens | ENSG00000108590 | mediator complex subunit 31 |
Loa Loa (eye worm) | LOAG_00110 | mediator complex subunit 31 |
Mus musculus | ENSMUSG00000020801 | mediator complex subunit 31 |
Neospora caninum | NCLIV_046860 | hypothetical protein |
Oryza sativa | 4349407 | Os10g0564100 |
Oryza sativa | 4342476 | Os07g0164600 |
Onchocerca volvulus | OVOC3039 |
|
Plasmodium berghei | PBANKA_1301200 | mediator of RNA polymerase II transcription subunit 31, putative |
Plasmodium falciparum | PF3D7_1475000 | mediator of RNA polymerase II transcription subunit 31, putative |
Plasmodium knowlesi | PKNH_1245300 | mediator of RNA polymerase II transcription subunit 31, putative |
Plasmodium vivax | PVX_118630 | hypothetical protein, conserved |
Plasmodium yoelii | PY00705 | hypothetical protein |
Saccharomyces cerevisiae | YGL127C | Soh1p |
Schistosoma japonicum | Sjp_0089880 | Mediator of RNA polymerase II transcription subunit 31, putative |
Schistosoma mansoni | Smp_024060.2 | hypothetical protein |
Schistosoma mansoni | Smp_024060.1 | hypothetical protein |
Schmidtea mediterranea | mk4.014726.00 | |
Schmidtea mediterranea | mk4.004851.00 | |
Toxoplasma gondii | TGME49_225970 | mediator complex subunit MED31 |
Trichomonas vaginalis | TVAG_342960 | soh1 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F32H2.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_225970 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.