pI: 9.3248 |
Length (AA): 299 |
MW (Da): 34316 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
57 | 109 | 2xz4 (A) | 58 | 106 | 35.00 | 0.87 | 0.35 | 0.140658 | 2.45 |
168 | 228 | 3llr (A) | 71 | 143 | 30.00 | 0.87 | 0.81 | 0.606413 | -0.28 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126881)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G71990 | alpha-(1,4)-fucosyltransferase |
Brugia malayi | Bm1_43965 | alpha1,3-fucosyltransferase homologue |
Brugia malayi | Bm1_53055 | Fucosyl transferase family protein |
Caenorhabditis elegans | CELE_K12H6.3 | Protein FUT-4 |
Caenorhabditis elegans | CELE_F59E12.13 | Protein FUT-3 |
Caenorhabditis elegans | CELE_T05A7.10 | Protein FUT-5 |
Caenorhabditis elegans | CELE_T05A7.5 | Protein FUT-6 |
Caenorhabditis elegans | CELE_K08F8.3 | Protein FUT-1 |
Dictyostelium discoideum | DDB_G0284775 | hypothetical protein |
Dictyostelium discoideum | DDB_G0274297 | hypothetical protein |
Dictyostelium discoideum | DDB_G0284467 | hypothetical protein |
Drosophila melanogaster | Dmel_CG40305 | CG40305 gene product from transcript CG40305-RB |
Drosophila melanogaster | Dmel_CG6869 | CG6869 gene product from transcript CG6869-RA |
Echinococcus granulosus | EgrG_000169600 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus granulosus | EgrG_000780500 | Transcription initiation factor TFIID subunit |
Echinococcus granulosus | EgrG_002035800 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus granulosus | EgrG_000370400 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus granulosus | EgrG_000170800 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus granulosus | EgrG_000370300 | alpha13fucosyltransferase |
Echinococcus multilocularis | EmuJ_000170800 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus multilocularis | EmuJ_000780500 | Transcription initiation factor TFIID subunit |
Echinococcus multilocularis | EmuJ_000169600 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus multilocularis | EmuJ_001089700 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus multilocularis | EmuJ_000370400 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus multilocularis | EmuJ_000398100 | glycoprotein 3 alpha L fucosyltransferase |
Echinococcus multilocularis | EmuJ_000370300 | alpha(13)fucosyltransferase |
Echinococcus multilocularis | EmuJ_000997900 | alpha(13)fucosyltransferase |
Homo sapiens | ENSG00000171124 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
Homo sapiens | ENSG00000130383 | fucosyltransferase 5 (alpha (1,3) fucosyltransferase) |
Homo sapiens | ENSG00000172461 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase) |
Homo sapiens | ENSG00000156413 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase) |
Homo sapiens | ENSG00000196371 | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Loa Loa (eye worm) | LOAG_06811 | fucosyl transferase |
Loa Loa (eye worm) | LOAG_14246 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15422 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00850 | hypothetical protein |
Mus musculus | ENSMUSG00000055373 | fucosyltransferase 9 |
Mus musculus | ENSMUSG00000049307 | fucosyltransferase 4 |
Oryza sativa | 9270041 | Os04g0432366 |
Oryza sativa | 4351626 | Os12g0170600 |
Onchocerca volvulus | OVOC6248 | Alpha 1,3 fucosyltransferase homolog |
Schistosoma japonicum | Sjp_0202180 | Glycoprotein 3-alpha-L-fucosyltransferase A, putative |
Schistosoma japonicum | Sjp_0012850 | expressed protein |
Schistosoma japonicum | Sjp_0304270 | ko:K03663 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase [EC2.4.1.152], putative |
Schistosoma japonicum | Sjp_0126380 | IPR001503,Glycosyl transferase, family 10,domain-containing |
Schistosoma japonicum | Sjp_0070210 | Glycoprotein 3-alpha-L-fucosyltransferase A, putative |
Schistosoma japonicum | Sjp_0036210 | ko:K07634 galactoside alpha-1,3-fucosyltransferase 6, putative |
Schistosoma japonicum | Sjp_0083880 | Glycoprotein 3-alpha-L-fucosyltransferase A, putative |
Schistosoma japonicum | Sjp_0044100 | ko:K07632 galactoside alpha-1,3-fucosyltransferase 4, putative |
Schistosoma japonicum | Sjp_0039260 | expressed protein |
Schistosoma japonicum | Sjp_0012280 | ko:K07635 galactoside alpha-1,3-fucosyltransferase 7, putative |
Schistosoma japonicum | Sjp_0012830 | ko:K03126 transcription initiation factor TFIID subunit D10, putative |
Schistosoma mansoni | Smp_154410 | alpha(13)fucosyltransferase |
Schistosoma mansoni | Smp_054300 | alpha(13)fucosyltransferase |
Schistosoma mansoni | Smp_148850 | alpha(13)fucosyltransferase |
Schistosoma mansoni | Smp_129750 | alpha(13)fucosyltransferase |
Schistosoma mansoni | Smp_099090 | alpha(13)fucosyltransferase |
Schmidtea mediterranea | mk4.024075.00 | Glycoprotein 3-alpha-L-fucosyltransferase A |
Schmidtea mediterranea | mk4.004635.06 | |
Schmidtea mediterranea | mk4.009806.03 | |
Schmidtea mediterranea | mk4.014138.01 | Glycoprotein 3-alpha-L-fucosyltransferase A |
Schmidtea mediterranea | mk4.012562.00 | Glycoprotein 3-alpha-L-fucosyltransferase A |
Schmidtea mediterranea | mk4.022564.01 | |
Schmidtea mediterranea | mk4.004009.05 | Glycoprotein 3-alpha-L-fucosyltransferase A |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) | Compounds | References |
Homo sapiens | fucosyltransferase 6 (alpha (1,3) fucosyltransferase) | Compounds | References |
Homo sapiens | fucosyltransferase 5 (alpha (1,3) fucosyltransferase) | Compounds | References |