pI: 5.3427 |
Length (AA): 236 |
MW (Da): 26815 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 233 | 5b6a (A) | 101 | 288 | 23.00 | 0.000000042 | 1 | 1.04915 | 0.06 |
2 | 233 | 2f7k (A) | 100 | 311 | 41.00 | 0 | 1 | 1.33615 | 0.19 |
15 | 57 | 3h74 (A) | 105 | 148 | 44.00 | 0.031 | 0.99 | 0.693403 | -0.47 |
36 | 85 | 4xda (A) | 172 | 220 | 39.00 | 0.02 | 0.97 | 0.756064 | -0.82 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127394)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G37850 | Pyridoxal kinase |
Brugia malayi | Bm1_07835 | pyridoxal kinase |
Candida albicans | CaO19.3411 | same as N terminus of cosmid orf Ca20C1.16 |
Candida albicans | CaO19.9387 | similar to BUD17-like CaP19.3411 |
Candida albicans | CaO19.1828 | similar to BUD17-like CaP19.3411 |
Candida albicans | CaO19.10914 | similar to N terminus of S. cerevisiae BUD17 (YNR027W) |
Caenorhabditis elegans | CELE_F57C9.1 | Protein F57C9.1, isoform A |
Dictyostelium discoideum | DDB_G0268628 | pyridoxal kinase |
Drosophila melanogaster | Dmel_CG34455 | Pyridoxal kinase |
Escherichia coli | b1636 | pyridoxamine kinase |
Escherichia coli | b2418 | pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase |
Echinococcus granulosus | EgrG_000600600 | pyridoxal kinase |
Entamoeba histolytica | EHI_126090 | pyridoxal kinase, putative |
Echinococcus multilocularis | EmuJ_000600600 | pyridoxal kinase |
Homo sapiens | ENSG00000160209 | pyridoxal (pyridoxine, vitamin B6) kinase |
Leishmania braziliensis | LbrM.30.1370 | Pyridoxal kinase, putative |
Leishmania donovani | LdBPK_301310.1 | pyridoxal kinase, putative |
Leishmania infantum | LinJ.30.1310 | Pyridoxal kinase, putative |
Leishmania major | LmjF.30.1250 | Pyridoxal kinase, putative |
Leishmania mexicana | LmxM.29.1250 | Pyridoxal kinase, putative |
Loa Loa (eye worm) | LOAG_01254 | hypothetical protein |
Mus musculus | 102641556 | mucin-1-like |
Mus musculus | ENSMUSG00000032788 | pyridoxal (pyridoxine, vitamin B6) kinase |
Oryza sativa | 4352717 | Os12g0600400 |
Onchocerca volvulus | OVOC280 | Putative pyridoxal kinase |
Plasmodium berghei | PBANKA_1230800 | pyridoxal kinase, putative |
Plasmodium falciparum | PF3D7_0616000 | pyridoxal kinase |
Plasmodium knowlesi | PKNH_1134000 | pyridoxal kinase, putative |
Plasmodium vivax | PVX_113935 | pyridoxal kinase, putative |
Plasmodium yoelii | PY01633 | putative pyridoxine kinase |
Saccharomyces cerevisiae | YEL029C | putative pyridoxal kinase BUD16 |
Saccharomyces cerevisiae | YNR027W | putative pyridoxal kinase BUD17 |
Schistosoma japonicum | Sjp_0098930 | ko:K00868 pyridoxine kinase [EC2.7.1.35], putative |
Schistosoma mansoni | Smp_164250.1 | pyridoxine kinase |
Schistosoma mansoni | Smp_164250.2 | pyridoxine kinase |
Schmidtea mediterranea | mk4.008081.02 | |
Schmidtea mediterranea | mk4.000800.10 | |
Schmidtea mediterranea | mk4.004639.00 | Putative pyridoxal kinase |
Schmidtea mediterranea | mk4.010590.00 | |
Schmidtea mediterranea | mk4.010030.00 | |
Trypanosoma brucei gambiense | Tbg972.6.2510 | pyridoxal kinase |
Trypanosoma brucei | Tb927.6.2740 | pyridoxal kinase |
Trypanosoma congolense | TcIL3000_0_21240 | pyridoxal kinase |
Trypanosoma cruzi | TcCLB.509059.50 | pyridoxal kinase, putative |
Trypanosoma cruzi | TcCLB.507925.40 | pyridoxal kinase, putative |
Trichomonas vaginalis | TVAG_493290 | phosphomethylpyrimidine kinase, putative |
Trichomonas vaginalis | TVAG_425810 | phosphomethylpyrimidine kinase, putative |
Trichomonas vaginalis | TVAG_132920 | pyridoxine kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.2740 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.2740 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.2740 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.2740 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1636 | Escherichia coli | non-essential | goodall |
b2418 | Escherichia coli | non-essential | goodall |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | pyridoxal (pyridoxine, vitamin B6) kinase | Compounds | References |