Detailed view for EgrG_000963400

Basic information

TDR Targets ID: 588719
Echinococcus granulosus, protein tyrosine sulfotransferase
Source Database / ID:  GeneDB

pI: 8.2323 | Length (AA): 368 | MW (Da): 42242 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13469   Sulfotransferase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008476   protein-tyrosine sulfotransferase activity  
GO:0006478   peptidyl-tyrosine sulfation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
82 360 3ap1 (A) 69 352 40.00 0 1 1.33335 -1.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131132)

Species Accession Gene Product
Brugia malayi Bm1_44780   Protein-tyrosine sulfotransferase A
Caenorhabditis elegans CELE_Y111B2A.15   Protein TPST-1
Drosophila melanogaster Dmel_CG32632   Transport and Golgi organization 13
Echinococcus granulosus EgrG_000963400   protein tyrosine sulfotransferase
Echinococcus multilocularis EmuJ_000963400   protein tyrosine sulfotransferase
Homo sapiens ENSG00000128294   tyrosylprotein sulfotransferase 2
Homo sapiens ENSG00000169902   tyrosylprotein sulfotransferase 1
Loa Loa (eye worm) LOAG_03971   protein-tyrosine sulfotransferase A
Mus musculus ENSMUSG00000034118   protein-tyrosine sulfotransferase 1
Mus musculus ENSMUSG00000029344   protein-tyrosine sulfotransferase 2
Schistosoma japonicum Sjp_0117580   IPR002223,Proteinase inhibitor I2, Kunitz metazoa,domain-containing
Schistosoma japonicum Sjp_0214090   IPR002223,Proteinase inhibitor I2, Kunitz metazoa,domain-containing
Schistosoma japonicum Sjp_0046080   Protein-tyrosine sulfotransferase A, putative
Schistosoma japonicum Sjp_0203550   ko:K01021 protein-tyrosine sulfotransferase [EC2.8.2.20], putative
Schistosoma mansoni Smp_129700   protein-tyrosine sulfotransferase
Schistosoma mansoni Smp_147690   hypothetical protein
Schistosoma mansoni Smp_147700   hypothetical protein
Schmidtea mediterranea mk4.000356.04   Putative protein-tyrosine sulfotransferase

Essentiality

EgrG_000963400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y111B2A.15 Caenorhabditis elegans larval arrest wormbase
CELE_Y111B2A.15 Caenorhabditis elegans larval lethal wormbase
CELE_Y111B2A.15 Caenorhabditis elegans slow growth wormbase
CELE_Y111B2A.15 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000963400 (Echinococcus granulosus), protein tyrosine sulfotransferase
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