Detailed view for EgrG_000254200

Basic information

TDR Targets ID: 588953
Echinococcus granulosus, proteasome assembly chaperone 2
Source Database / ID:  GeneDB

pI: 5.307 | Length (AA): 265 | MW (Da): 28782 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09754   PAC2 family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 245 3vr0 (A) 14 242 17.00 0 1 1.10608 -0.06
17 203 3gaa (A) 25 209 18.00 0 0.99 0.86606 -0.26
17 203 3vr0 (A) 28 231 20.00 0 1 0.86706 -0.16
25 140 3vav (C) 142 267 32.00 0.55 0.29 0.580336 0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130733)

Species Accession Gene Product
Arabidopsis thaliana AT3G18940   clast3-related protein
Candida albicans CaO19.9818   weak similarity to mouse CLAST3 cell cycle-regulated gene and to YKL206c.
Candida albicans CaO19.2278   weak similarity to mouse CLAST3 cell cycle-regulated gene and to YKL206c.
Dictyostelium discoideum DDB_G0274447   proteasome assembly chaperone 2
Drosophila melanogaster Dmel_CG12321   CG12321 gene product from transcript CG12321-RA
Echinococcus granulosus EgrG_000254200   proteasome assembly chaperone 2
Entamoeba histolytica EHI_040290   hypothetical protein
Echinococcus multilocularis EmuJ_000254200   proteasome assembly chaperone 2
Homo sapiens ENSG00000128789   proteasome (prosome, macropain) assembly chaperone 2
Mus musculus ENSMUSG00000024537   proteasome (prosome, macropain) assembly chaperone 2
Oryza sativa 4334232   Os03g0766900
Saccharomyces cerevisiae YKL206C   Add66p
Schistosoma mansoni Smp_126670   hypothetical protein
Schmidtea mediterranea mk4.001301.02  
Trichomonas vaginalis TVAG_377850   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proteasome (prosome, macropain) assembly chaperone 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000254200 (Echinococcus granulosus), proteasome assembly chaperone 2
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