pI: 6.0969 |
Length (AA): 403 |
MW (Da): 46465 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 403 | 4c9b (A) | 21 | 411 | 81.00 | 0 | 1 | 2.03662 | -1.66 |
272 | 362 | 5nt7 (B) | 492 | 588 | 41.00 | 0 | 1 | 0.916206 | -1.9 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127927)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G19760 | DEAD-box ATP-dependent RNA helicase 2 |
Babesia bovis | BBOV_IV010990 | eukaryotic initiation factor 4A-3 (eIF4A-3), putative |
Brugia malayi | Bm1_14510 | ATP-dependent helicase DDX48 |
Candida albicans | CaO19.2488 | DEAD-box protein, putative RNA helicase similar to S. cerevisiae FAL1 (YDR021W) involved in rRNA processing |
Candida albicans | CaO19.10024 | DEAD-box protein, putative RNA helicase similar to S. cerevisiae FAL1 (YDR021W) involved in rRNA processing |
Caenorhabditis elegans | CELE_Y65B4A.6 | Protein Y65B4A.6 |
Caenorhabditis elegans | CELE_F33D11.10 | Protein F33D11.10 |
Cryptosporidium hominis | Chro.70440 | eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3) |
Cryptosporidium parvum | cgd7_3940 | eIF4A-1; eukaryotic translation initiation factor 4A-1; RNA SFII helicase |
Dictyostelium discoideum | DDB_G0269192 | DEAD/DEAH box helicase domain-containing protein |
Drosophila melanogaster | Dmel_CG7483 | CG7483 gene product from transcript CG7483-RA |
Echinococcus granulosus | EgrG_001193600 | eukaryotic initiation factor 4A III |
Echinococcus granulosus | EgrG_000033400 | DEAD box ATP dependent RNA helicase |
Entamoeba histolytica | EHI_106300 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_000371200 | DEAD box ATP dependent RNA helicase |
Echinococcus multilocularis | EmuJ_001193600 | eukaryotic initiation factor 4A III |
Echinococcus multilocularis | EmuJ_000033400 | DEAD box ATP dependent RNA helicase |
Homo sapiens | ENSG00000141543 | eukaryotic translation initiation factor 4A3 |
Leishmania braziliensis | LbrM.28.1700 | DEAD box RNA helicase, putative |
Leishmania donovani | LdBPK_281660.1 | DEAD box RNA helicase, putative |
Leishmania infantum | LinJ.28.1660 | DEAD box RNA helicase, putative |
Leishmania major | LmjF.28.1530 | ATP dependent DEAD-box helicase, putative |
Leishmania mexicana | LmxM.28.1530 | DEAD box RNA helicase, putative |
Loa Loa (eye worm) | LOAG_07474 | ATP-dependent helicase DDX48 |
Mus musculus | 668137 | predicted gene 8994 |
Mus musculus | ENSMUSG00000025580 | eukaryotic translation initiation factor 4A3 |
Mus musculus | 102641531 | eukaryotic initiation factor 4A-III-like |
Neospora caninum | NCLIV_015210 | ATP-dependent helicase, putaive, putative |
Oryza sativa | 4326580 | Os01g0639100 |
Oryza sativa | 4333273 | Os03g0566800 |
Plasmodium berghei | PBANKA_0523100 | eukaryotic initiation factor 4A-III, putative |
Plasmodium falciparum | PF3D7_0422700 | eukaryotic initiation factor 4A-III, putative |
Plasmodium knowlesi | PKNH_0514600 | eukaryotic initiation factor 4A-III, putative |
Plasmodium vivax | PVX_090175 | eukaryotic initiation factor, putative |
Plasmodium yoelii | PY06447 | eukaryotic initiation factor 4a-3 |
Saccharomyces cerevisiae | YDR021W | ATP-dependent RNA helicase FAL1 |
Schistosoma japonicum | Sjp_0055030 | ko:K03257 translation initiation factor eIF-4A, putative |
Schistosoma mansoni | Smp_034190.2 | DEAD box ATP-dependent RNA helicase |
Schistosoma mansoni | Smp_034190.1 | DEAD box ATP-dependent RNA helicase |
Schmidtea mediterranea | mk4.001215.00 | Eukaryotic initiation factor 4A-III |
Schmidtea mediterranea | mk4.000568.02 | Putative dead box ATP-dependent RNA helicase |
Trypanosoma brucei gambiense | Tbg972.11.9800 | ATP-dependent DEAD/H RNA helicase, putative,DEAD box RNA helicase, putative,RNA helicase, putative |
Trypanosoma brucei | Tb927.11.8770 | ATP-dependent RNA helicase FAL1, putative |
Trypanosoma congolense | TcIL3000.11.9080 | ATP-dependent RNA helicase FAL1, putative |
Trypanosoma cruzi | TcCLB.506587.40 | ATP-dependent RNA helicase FAL1, putative |
Toxoplasma gondii | TGME49_256770 | eukaryotic translation initiation factor 4A, isoform 3, putative |
Theileria parva | TP01_0765 | eukaryotic translation initiation factor 4A, putative |
Trichomonas vaginalis | TVAG_286500 | DEAD box ATP-dependent RNA helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.12.0011 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.12.0011 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.12.0011 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.12.0011 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F33D11.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F33D11.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F33D11.10 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F33D11.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F33D11.10 | Caenorhabditis elegans | sterile | wormbase |
CELE_Y65B4A.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y65B4A.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y65B4A.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y65B4A.6 | Caenorhabditis elegans | sterile | wormbase |
YDR021W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0523100 | Plasmodium berghei | Essential | plasmo |
TGME49_256770 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.