pI: 7.2053 |
Length (AA): 423 |
MW (Da): 46632 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 419 | 3mw9 (A) | 1 | 415 | 53.00 | 0 | 1 | 1.64812 | -0.42 |
243 | 348 | 1x13 (A) | 1161 | 1280 | 22.00 | 0 | 0.6 | 0.464091 | -0.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126857)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G07440 | glutamate dehydrogenase 2 |
Arabidopsis thaliana | AT1G51720 | amino acid dehydrogenase family protein |
Arabidopsis thaliana | AT5G18170 | glutamate dehydrogenase 1 |
Arabidopsis thaliana | AT3G03910 | glutamate dehydrogenase 3 |
Babesia bovis | BBOV_IV010390 | glutamate dehydrogenase, putative |
Brugia malayi | Bm1_08210 | glutamate dehydrogenase, mitochondrial precursor, putative |
Brugia malayi | Bm1_13615 | glutamate dehydrogenase, mitochondrial precursor, putative |
Candida albicans | CaO19.4716 | similar to S. cerevisiae NADP-specific glutamate dehydrogenase GDH1 (YOR375C) |
Caenorhabditis elegans | CELE_ZK829.4 | Protein GDH-1 |
Dictyostelium discoideum | DDB_G0287469 | NAD-dependent glutamate dehydrogenase |
Drosophila melanogaster | Dmel_CG4434 | CG4434 gene product from transcript CG4434-RA |
Drosophila melanogaster | Dmel_CG5320 | Glutamate dehydrogenase |
Escherichia coli | b1761 | glutamate dehydrogenase, NADP-specific |
Echinococcus granulosus | EgrG_000604400 | Glutamate dehydrogenase mitochondrial |
Echinococcus granulosus | EgrG_000589100 | glutamate dehydrogenase |
Echinococcus multilocularis | EmuJ_000589100 | glutamate dehydrogenase |
Echinococcus multilocularis | EmuJ_000604400 | Glutamate dehydrogenase, mitochondrial |
Giardia lamblia | GL50803_21942 | NADP-specific glutamate dehydrogenase |
Homo sapiens | ENSG00000148672 | glutamate dehydrogenase 1 |
Homo sapiens | ENSG00000182890 | glutamate dehydrogenase 2 |
Leishmania braziliensis | LbrM.28.3120 | glutamate dehydrogenase, putative |
Leishmania donovani | LdBPK_283140.1 | glutamate dehydrogenase, putative |
Leishmania infantum | LinJ.28.3140 | glutamate dehydrogenase, putative |
Leishmania major | LmjF.28.2910 | glutamate dehydrogenase, putative |
Leishmania mexicana | LmxM.28.2910 | glutamate dehydrogenase, putative |
Mus musculus | ENSMUSG00000021794 | glutamate dehydrogenase 1 |
Neospora caninum | NCLIV_000130 | hypothetical protein |
Oryza sativa | 4324672 | Os01g0558200 |
Oryza sativa | 4330164 | Os02g0650900 |
Oryza sativa | 4336554 | Os04g0543900 |
Oryza sativa | 4334405 | Os03g0794500 |
Onchocerca volvulus | OVOC9031 | Glutamate dehydrogenase, mitochondrial homolog |
Onchocerca volvulus | OVOC8679 | Glutamate dehydrogenase, mitochondrial homolog |
Plasmodium berghei | PBANKA_1026200 | NADP-specific glutamate dehydrogenase, putative |
Plasmodium berghei | PBANKA_1014000 | NADP-specific glutamate dehydrogenase, putative |
Plasmodium falciparum | PF3D7_1430700 | NADP-specific glutamate dehydrogenase |
Plasmodium falciparum | PF3D7_1416500 | NADP-specific glutamate dehydrogenase |
Plasmodium knowlesi | PKNH_1341600 | NADP-specific glutamate dehydrogenase, putative |
Plasmodium knowlesi | PKNH_1328000 | NADP-specific glutamate dehydrogenase, putative |
Plasmodium vivax | PVX_085625 | glutamate dehydrogenase (NADP+), putative |
Plasmodium yoelii | PY04261 | glutamate dehydrogenase |
Plasmodium yoelii | PY01264 | glutamate dehydrogenase |
Saccharomyces cerevisiae | YOR375C | glutamate dehydrogenase (NADP(+)) GDH1 |
Saccharomyces cerevisiae | YAL062W | glutamate dehydrogenase (NADP(+)) GDH3 |
Schistosoma japonicum | Sjp_0114080 | ko:K00261 glutamate dehydrogenase (NAD(P)+) [EC1.4.1.3], putative |
Schistosoma mansoni | Smp_093820 | glutamate dehydrogenase |
Schmidtea mediterranea | mk4.001394.08 | Glutamate dehydrogenase |
Schmidtea mediterranea | mk4.001394.07 | Glutamate dehydrogenase, mitochondrial |
Trypanosoma cruzi | TcCLB.508111.30 | glutamate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.507875.20 | glutamate dehydrogenase, putative |
Toxoplasma gondii | TGME49_293180 | NADP-specific glutamate dehydrogenase |
Trichomonas vaginalis | TVAG_072100 | glutamate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_025910 | glutamate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_201620 | glutamate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_025980 | glutamate dehydrogenase, putative |
Trichomonas vaginalis | TVAG_196700 | glutamate dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1761 | Escherichia coli | non-essential | goodall |
CELE_ZK829.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK829.4 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1014000 | Plasmodium berghei | Slow | plasmo |
TGME49_293180 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Bos taurus | Glutamate dehydrogenase | Compounds | References |