Detailed view for EgrG_000833600

Basic information

TDR Targets ID: 591077
Echinococcus granulosus, dolichyl phosphate beta glucosyltransferase
Source Database / ID:  GeneDB

pI: 9.2056 | Length (AA): 329 | MW (Da): 37897 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00535   Glycosyl transferase family 2

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

N-Glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
68 181 3bcv (A) 5 107 30.00 0 0.99 0.731105 -0.92
68 186 5tz8 (A) 1 108 37.00 0.0000000093 0.86 0.674702 -0.02
70 168 5hea (A) 7 94 36.00 0.0000016 1 0.703912 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128591)

Species Accession Gene Product
Arabidopsis thaliana AT2G39630   putative dolichyl-phosphate beta-glucosyltransferase
Brugia malayi Bm1_17955   dolichyl-phosphate beta-glucosyltransferase
Candida albicans CaO19.2837   dolichol-P-glucose synthetase
Candida albicans CaO19.10355   dolichol-P-glucose synthetase
Caenorhabditis elegans CELE_H43I07.3   Protein H43I07.3
Cryptosporidium hominis Chro.50118   dolichyl phosphate glucosyltransferase
Cryptosporidium parvum cgd5_2590   Alg5 like dolichyl-phosphate beta-glucosyltransferase
Dictyostelium discoideum DDB_G0288321   dolichyl phosphate glucosyltransferase
Drosophila melanogaster Dmel_CG7870   wollknaeuel
Echinococcus granulosus EgrG_000833600   dolichyl phosphate beta glucosyltransferase
Echinococcus multilocularis EmuJ_000833600   dolichyl phosphate beta glucosyltransferase
Homo sapiens ENSG00000120697   ALG5, dolichyl-phosphate beta-glucosyltransferase
Mycobacterium leprae ML0207   Possible transferase (possibly glycosyltransferase)
Mus musculus ENSMUSG00000036632   asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase)
Neospora caninum NCLIV_059710   Dolichol phosphate glucosyltransferase, related
Oryza sativa 4334604   Os03g0821800
Saccharomyces cerevisiae YPL227C   dolichyl-phosphate beta-glucosyltransferase
Schistosoma japonicum Sjp_0210890   ko:K00729 dolichyl-phosphate beta-glucosyltransferase [EC2.4.1.117], putative
Schistosoma mansoni Smp_032780   dolichyl-phosphate beta-glucosyltransferase ( dolp-glucosyltransferase)
Schmidtea mediterranea mk4.000007.35   Dolichyl-phosphate beta-glucosyltransferase
Toxoplasma gondii TGME49_216540   dolichyl-phosphate beta-glucosyltransferase
Trichomonas vaginalis TVAG_347770   dolichol-phosphate mannosyltransferase, putative
Trichomonas vaginalis TVAG_358380   dolichol-phosphate mannosyltransferase, putative
Trichomonas vaginalis TVAG_487200   glycosyltransferase, putative
Trichomonas vaginalis TVAG_174740   dolichol-phosphate mannosyltransferase, putative
Trichomonas vaginalis TVAG_221700   dolichol-phosphate mannosyltransferase, putative

Essentiality

EgrG_000833600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_216540 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000833600 (Echinococcus granulosus), dolichyl phosphate beta glucosyltransferase
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