Detailed view for EgrG_000761600

Basic information

TDR Targets ID: 591143
Echinococcus granulosus, WD repeat protein
Source Database / ID:  GeneDB

pI: 8.972 | Length (AA): 803 | MW (Da): 89450 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
454 729 5hqg (A) 457 718 24.00 0.000017 0.88 0.421011 0.52
464 543 5u5t (A) 186 270 33.00 0.07 0.92 0.496926 -0.94
465 536 3vl1 (A) 133 205 36.00 0.79 0.25 0.393964 -0.28
466 696 4cy3 (A) 112 316 32.00 0 1 0.475971 -0.07
481 544 4j87 (A) 109 172 30.00 0.0023 0.4 0.472001 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129210)

Species Accession Gene Product
Arabidopsis thaliana AT2G37670   WD-40 repeat-containing protein
Arabidopsis thaliana AT5G02430   transducin/WD40 domain-containing protein
Arabidopsis thaliana AT3G15470   WD40 domain-containing protein
Arabidopsis thaliana AT5G54200   transducin/WD40 domain-containing protein
Brugia malayi Bm1_14955   Hypothetical WD-repeats containing protein YKL121w, putative
Candida albicans CaO19.7235   similar to S. pombe SPAC3H5.08c and to S. cerevisiae YKL121W
Caenorhabditis elegans CELE_R03E1.1   Protein SYM-4
Cryptosporidium hominis Chro.70601   RIKEN cDNA 2610034K17
Cryptosporidium parvum cgd7_5410   WD40 protein
Dictyostelium discoideum DDB_G0282491   hypothetical protein
Drosophila melanogaster Dmel_CG34133   CG34133 gene product from transcript CG34133-RC
Echinococcus granulosus EgrG_000761600   WD repeat protein
Echinococcus multilocularis EmuJ_000761600   WD repeat protein
Homo sapiens ENSG00000131725   WD repeat domain 44
Mus musculus ENSMUSG00000036769   WD repeat domain 44
Oryza sativa 9267200   Os12g0178633
Oryza sativa 4337413   Os04g0678300
Oryza sativa 9269146   Os04g0529400
Oryza sativa 9270524   Os11g0187000
Saccharomyces cerevisiae YMR102C   hypothetical protein
Schistosoma japonicum Sjp_0216010   expressed protein
Schistosoma mansoni Smp_171200   hypothetical protein
Schmidtea mediterranea mk4.001347.03   Putative wd-repeat protein
Toxoplasma gondii TGME49_263360   WD domain, G-beta repeat-containing protein
Trichomonas vaginalis TVAG_078530   WD repeat domain, putative
Trichomonas vaginalis TVAG_135970   WD repeat domain, putative

Essentiality

EgrG_000761600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R03E1.1 Caenorhabditis elegans slow growth wormbase
TGME49_263360 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Cricetulus griseus Thymidine kinase, cytosolic 234 aa 23.7% 215 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000761600 (Echinococcus granulosus), WD repeat protein
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