Detailed view for EgrG_001008900

Basic information

TDR Targets ID: 591845
Echinococcus granulosus, Diacylglycerol kinase theta
Source Database / ID:  GeneDB

pI: 6.733 | Length (AA): 1184 | MW (Da): 129996 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00130   Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00609   Diacylglycerol kinase accessory domain
PF00781   Diacylglycerol kinase catalytic domain
PF00788   Ras association (RalGDS/AF-6) domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016301   kinase activity  
GO:0004143   diacylglycerol kinase activity  
GO:0003951   NAD+ kinase activity  
GO:0008152   metabolic process  
GO:0007205   activation of protein kinase C activity  
GO:0007165   signal transduction  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 71 4b7y (D) 39 111 39.00 0.14 0.12 0.282997 1.19
36 83 1y8f (A) 567 616 25.00 0 0.27 0.117741 1.22
219 309 1r79 (A) 1 82 40.00 0 0.79 0.321058 0.39
255 305 1ptq (A) 231 280 28.00 0.62 0.3 0.324774 -0.09
471 576 2m4n (A) 2 108 18.00 0 0.68 0.205727 -0.74
471 523 3vy8 (X) 179 229 39.00 0.29 0.08 0.266464 1.29
668 767 3s40 (A) 7 105 35.00 0.22 0.92 0.342159 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134203)

Species Accession Gene Product
Brugia malayi Bm1_31470   diacylglycerol kinase
Brugia malayi Bm1_04650   diacylglycerol kinase
Caenorhabditis elegans CELE_C09E10.2   Protein DGK-1, isoform C
Drosophila melanogaster Dmel_CG31140   CG31140 gene product from transcript CG31140-RB
Echinococcus granulosus EgrG_001008900   Diacylglycerol kinase theta
Echinococcus multilocularis EmuJ_001008900   Diacylglycerol kinase theta
Echinococcus multilocularis EmuJ_001005300   Diacylglycerol kinase theta
Homo sapiens ENSG00000145214   diacylglycerol kinase, theta 110kDa
Loa Loa (eye worm) LOAG_10788   hypothetical protein
Loa Loa (eye worm) LOAG_00390   hypothetical protein
Mus musculus ENSMUSG00000004815   diacylglycerol kinase, theta
Schistosoma japonicum Sjp_0044900   Diacylglycerol kinase theta, putative
Schistosoma japonicum Sjp_0125070   Diacylglycerol kinase theta, putative
Schistosoma japonicum Sjp_0006700   ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative
Schistosoma mansoni Smp_163080   diacylglycerol kinase theta
Schistosoma mansoni Smp_036180   diacylglycerol kinase theta
Schmidtea mediterranea mk4.005786.00  
Schmidtea mediterranea mk4.013890.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.009593.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.024450.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.033920.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.002177.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.016753.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.011009.01   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.017874.00   Diacylglycerol kinase theta
Schmidtea mediterranea mk4.013496.00   Diacylglycerol kinase theta

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001008900 (Echinococcus granulosus), Diacylglycerol kinase theta
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