Detailed view for EgrG_000532000

Basic information

TDR Targets ID: 591904
Echinococcus granulosus, eukaryotic translation initiation factor 3
Source Database / ID:  GeneDB

pI: 5.6354 | Length (AA): 244 | MW (Da): 28200 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10075   CSN8/PSMD8/EIF3K family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0043022   ribosome binding  
GO:0005488   binding  
GO:0003743   translation initiation factor activity  
GO:0006446   regulation of translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 226 1rz4 (A) 5 216 43.00 0 1 1.50293 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129022)

Species Accession Gene Product
Arabidopsis thaliana AT4G33250   translation initiation factor 3 subunit K
Babesia bovis BBOV_III006700   hypothetical protein
Brugia malayi Bm1_52955   Eukaryotic translation initiation factor 3 subunit 11, putative
Caenorhabditis elegans CELE_T16G1.11   Protein EIF-3.K
Cryptosporidium hominis Chro.30453   CG10306-PA
Cryptosporidium parvum cgd3_4020   eIF-3 p25/subunit 11
Dictyostelium discoideum DDB_G0291404   eukaryotic translation initiation factor 3, subunit 12
Drosophila melanogaster Dmel_CG10306   CG10306 gene product from transcript CG10306-RA
Echinococcus granulosus EgrG_000532000   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_000532000   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000178982   eukaryotic translation initiation factor 3, subunit K
Leishmania braziliensis LbrM.32.2400   hypothetical protein, conserved
Leishmania donovani LdBPK_322330.1   eukaryotic translation initiation factor 3 subunit k
Leishmania infantum LinJ.32.2330   hypothetical protein, conserved
Leishmania major LmjF.32.2180   hypothetical protein, conserved
Leishmania mexicana LmxM.31.2180   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05645   eukaryotic translation initiation factor 3 subunit 11
Mus musculus ENSMUSG00000053565   eukaryotic translation initiation factor 3, subunit K
Neospora caninum NCLIV_025580   eukaryotic translation initiation factor 3 subunit 11, putative
Oryza sativa 4331842   Os03g0182700
Plasmodium berghei PBANKA_0408600   eukaryotic translation initiation factor 3 subunit K, putative
Plasmodium falciparum PF3D7_0310600   eukaryotic translation initiation factor 3 subunit K, putative, unspecified product
Plasmodium knowlesi PKNH_0832100   eukaryotic translation initiation factor 3 subunit K, putative
Plasmodium vivax PVX_119635   eukaryotic translation initiation factor 3 subunit 11, putative
Plasmodium yoelii PY04581   hypothetical protein
Schistosoma japonicum Sjp_0305010   Eukaryotic translation initiation factor 3 subunit K, putative
Schistosoma mansoni Smp_099320   hypothetical protein
Schmidtea mediterranea mk4.000932.08  
Trypanosoma brucei gambiense Tbg972.11.17300   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.15420   eukaryotic translation initiation factor 3 subunit k
Trypanosoma congolense TcIL3000.11.14080   eukaryotic translation initiation factor 3 subunit k
Trypanosoma cruzi TcCLB.509267.40   eukaryotic translation initiation factor 3 subunit k
Trypanosoma cruzi TcCLB.507967.30   eukaryotic translation initiation factor 3 subunit k
Toxoplasma gondii TGME49_262040   SAC3/GANP family protein
Theileria parva TP02_0303   hypothetical protein

Essentiality

EgrG_000532000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.7070 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.7070 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7070 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.7070 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0408600 Plasmodium berghei Slow plasmo
TGME49_262040 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000532000 (Echinococcus granulosus), eukaryotic translation initiation factor 3
Title for this comment
Comment