Detailed view for EgrG_000146400

Basic information

TDR Targets ID: 591933
Echinococcus granulosus, mitochondrial phosphate carrier protein
Source Database / ID:  GeneDB

pI: 9.4375 | Length (AA): 315 | MW (Da): 34905 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
220 260 3c5y (A) 81 121 37.00 0.63 0.08 0.382659 1.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127220)

Species Accession Gene Product
Arabidopsis thaliana AT5G14040   1
Arabidopsis thaliana AT3G48850   2
Babesia bovis BBOV_IV003410   mitochondrial phosphate transporter
Brugia malayi Bm1_39280   Phosphate carrier protein, mitochondrial precursor, putative
Candida albicans CaO19.4885   likely mitochondrial carrier protein similar to S. cerevisiae MIR1 (YJR077C) putative inorganic phosphate transporter
Candida albicans CaO19.8973   likely mitochondrial carrier family protein similar to S. cerevisiae YER053C
Candida albicans CaO19.1395   likely mitochondrial carrier family protein similar to S. cerevisiae YER053C
Candida albicans CaO19.12349   likely mitochondrial carrier protein similar to S. cerevisiae MIR1 (YJR077C) putative inorganic phosphate transporter
Caenorhabditis elegans CELE_T05F1.8   Protein T05F1.8
Caenorhabditis elegans CELE_C33F10.12   Protein C33F10.12
Caenorhabditis elegans CELE_F01G4.6   Protein F01G4.6, isoform B
Cryptosporidium hominis Chro.20060   PfMPC
Cryptosporidium parvum cgd2_520   mitochondrial phosphate translocator
Dictyostelium discoideum DDB_G0293646   mitochondrial substrate carrier family protein
Dictyostelium discoideum DDB_G0295753   mitochondrial substrate carrier family protein
Drosophila melanogaster Dmel_CG9090   CG9090 gene product from transcript CG9090-RA
Drosophila melanogaster Dmel_CG4994   Mitochondrial phosphate carrier protein
Echinococcus granulosus EgrG_000146400   mitochondrial phosphate carrier protein
Echinococcus multilocularis EmuJ_000146400   mitochondrial phosphate carrier protein
Echinococcus multilocularis EmuJ_000137900   voltage dependent calcium channel
Homo sapiens ENSG00000075415   solute carrier family 25 (mitochondrial carrier
Leishmania braziliensis LbrM.34.4400   mitochondrial phosphate transporter, putative
Leishmania braziliensis LbrM.34.4410   mitochondrial phosphate transporter, putative
Leishmania infantum LinJ.35.4500   mitochondrial phosphate transporter, putative
Leishmania infantum LinJ.35.4490   mitochondrial phosphate transporter, putative
Leishmania major LmjF.35.4430   mitochondrial phosphate transporter, putative
Leishmania major LmjF.35.4420   mitochondrial phosphate transporter, putative
Leishmania mexicana LmxM.34.4430   mitochondrial phosphate transporter, putative
Loa Loa (eye worm) LOAG_00237   hypothetical protein
Mus musculus ENSMUSG00000061904   solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Mus musculus 102641364   phosphate carrier protein, mitochondrial-like
Neospora caninum NCLIV_067010   Mitochondrial phosphate carrier protein, related
Oryza sativa 4335983   Os04g0448800
Oryza sativa 4330845   Os02g0767500
Oryza sativa 4347248   Os09g0454600
Oryza sativa 4340459   Os06g0210500
Onchocerca volvulus OVOC4957   Phosphate carrier protein, mitochondrial homolog
Plasmodium berghei PBANKA_0601100   mitochondrial phosphate carrier protein, putative
Plasmodium falciparum PF3D7_1202200   mitochondrial phosphate carrier protein
Plasmodium knowlesi PKNH_1302100   mitochondrial phosphate carrier protein, putative
Plasmodium vivax PVX_084135   mitochondrial carrier protein, putative
Plasmodium yoelii PY00463   PfMPC
Saccharomyces cerevisiae YER053C   Pic2p
Saccharomyces cerevisiae YJR077C   Mir1p
Schistosoma japonicum Sjp_0071850   Phosphate carrier protein, mitochondrial precursor, putative
Schistosoma mansoni Smp_083720   mitochondrial phosphate carrier protein
Schmidtea mediterranea mk4.000708.07   Putative mitochondrial phosphate carrier protein
Trypanosoma brucei gambiense Tbg972.9.5970   mitochondrial carrier protein, putative,mitochondrial phosphate transporter, putative
Trypanosoma brucei Tb927.9.10310   mitochondrial carrier protein 11
Trypanosoma congolense TcIL3000_9_3880   mitochondrial phosphate transporter, putative
Trypanosoma cruzi TcCLB.509551.30   mitochondrial phosphate transporter, putative
Toxoplasma gondii TGME49_278990   phosphate carrier, putative
Theileria parva TP01_1100   mitochondrial phosphate carrier, putative

Essentiality

EgrG_000146400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1750 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.1750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1750 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F01G4.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F01G4.6 Caenorhabditis elegans larval arrest wormbase
CELE_F01G4.6 Caenorhabditis elegans slow growth wormbase
CELE_F01G4.6 Caenorhabditis elegans sterile wormbase
PBANKA_0601100 Plasmodium berghei Essential plasmo
TGME49_278990 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000146400 (Echinococcus granulosus), mitochondrial phosphate carrier protein
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