Detailed view for EgrG_000429900

Basic information

TDR Targets ID: 592129
Echinococcus granulosus, transferase
Source Database / ID:  GeneDB

pI: 7.1979 | Length (AA): 905 | MW (Da): 100809 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01663   Type I phosphodiesterase / nucleotide pyrophosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051377   mannose-ethanolamine phosphotransferase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006506   GPI anchor biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
61 263 5egh (A) 26 245 28.00 0.0019 0.89 0.378509 -0.1
186 271 1p49 (A) 258 361 41.00 0.65 0.31 0.211228 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130048)

Species Accession Gene Product
Arabidopsis thaliana AT2G22530   alkaline-phosphatase-like family protein
Brugia malayi Bm1_46755   AEL166Cp
Caenorhabditis elegans CELE_F28C6.4   Protein F28C6.4, isoform B
Dictyostelium discoideum DDB_G0276251   transmembrane protein
Drosophila melanogaster Dmel_CG2144   CG2144 gene product from transcript CG2144-RA
Echinococcus granulosus EgrG_000429900   transferase
Echinococcus multilocularis EmuJ_000429900   transferase
Homo sapiens ENSG00000174227   phosphatidylinositol glycan anchor biosynthesis, class G
Loa Loa (eye worm) LOAG_03627   hypothetical protein
Loa Loa (eye worm) LOAG_03628   hypothetical protein
Mus musculus ENSMUSG00000029263   phosphatidylinositol glycan anchor biosynthesis, class G
Oryza sativa 9267717   Os02g0781500
Onchocerca volvulus OVOC9858   GPI ethanolamine phosphate transferase 2 homolog
Saccharomyces cerevisiae YJL062W   Las21p
Schistosoma mansoni Smp_061970   hypothetical protein
Schmidtea mediterranea mk4.009412.00   GPI ethanolamine phosphate transferase 2
Schmidtea mediterranea mk4.001918.05   GPI ethanolamine phosphate transferase 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000429900 (Echinococcus granulosus), transferase
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